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Cellosaurus TPC-1 (CVCL_6298)

[Text version]
Cell line name TPC-1
Synonyms TPC1
Accession CVCL_6298
Resource Identification Initiative To cite this cell line use: TPC-1 (RRID:CVCL_6298)
Comments Population: Japanese.
Omics: Genomics; Mitochondrial genome sequencing.
Omics: Metabolomics.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Sequence variations
  • Gene fusion; HGNC; HGNC:18782; CCDC6 + HGNC; HGNC:9967; RET; Name(s)=CCDC6-RET, RET/PTC1 (PubMed=7491517; PubMed=30737244).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Ala68fs (c.204_208delGGAGC); Zygosity=Homozygous (PubMed=30737244).
  • Mutation; HGNC; HGNC:11355; STAG2; Simple; p.Gln1089Ter (c.3265C>T); Zygosity=Heterozygous (PubMed=30737244).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=23833040; PubMed=30737244).
Disease Thyroid gland papillary carcinoma (NCIt: C4035)
Differentiated thyroid carcinoma (ORDO: Orphanet_146)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_6278 (BHP 10-3)CVCL_6282 (BHP 18-21)CVCL_6283 (BHP 2-7)
CVCL_6285 (BHP 7-13)CVCL_9917 (FB-2)CVCL_E3IT (HyCyte TPC-1-Luc)
CVCL_V277 (RPTC-1)
Sex of cell Female
Age at sampling Adult
Category Cancer cell line
STR profile Source(s): Millipore=SCC147; PubMed=18713817; PubMed=21868764; PubMed=30737244

Markers:
AmelogeninX
CSF1PO11,12
D3S135816,17
D5S8188,10
D7S82011
D8S117911,17
D13S31711,12
D16S5399
D18S5113,16
D21S1130,31.2
FGA20,21
Penta D9,13
Penta E18
TH019
TPOX11
vWA14,18

Run an STR similarity search on this cell line
Publications

PubMed=2823470; DOI=10.1016/0042-6822(87)90171-1
Junji Tanaka, Tsutomu Ogura, Hiroshi Sato, Motoichi Hatano;
Establishment and biological characterization of an in vitro human cytomegalovirus latency model.
Virology 161:62-72(1987)

PubMed=2516841; DOI=10.1111/j.1349-7006.1989.tb01645.x; PMCID=PMC5917935
Yukihito Ishizaka, Fumio Itoh, Tomoko Tahira, Isuzu Ikeda, Tsutomu Ogura, Takashi Sugimura, Minako Nagao;
Presence of aberrant transcripts of ret proto-oncogene in a human papillary thyroid carcinoma cell line.
Jpn. J. Cancer Res. 80:1149-1152(1989)

PubMed=2334411; DOI=10.1016/0006-291X(90)92335-W
Yukihito Ishizaka, Toshikazu Ushijima, Takashi Sugimura, Minako Nagao;
cDNA cloning and characterization of ret activated in a human papillary thyroid carcinoma cell line.
Biochem. Biophys. Res. Commun. 168:402-408(1990)

PubMed=7491517; DOI=10.1016/S0039-6060(05)80108-4
Gregg H. Jossart, Karin M. Greulich-Bode, Allan E. Siperstein, Quan-Yang Duh, Orlo Herrick Clark, Heinz-Ulrich Gunter Weier;
Molecular and cytogenetic characterization of a t(1;10;21) translocation in the human papillary thyroid cancer cell line TPC-1 expressing the ret/H4 chimeric transcript.
Surgery 118:1018-1023(1995)

PubMed=11439348; DOI=10.1038/sj.onc.1204531
Francesco Frasca, Paolo Vigneri, Veronica Vella, Riccardo Vigneri, Jean Y.-J. Wang;
Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to hepatocyte growth factor.
Oncogene 20:3845-3856(2001)

PubMed=14522906
Francesco Frasca, Veronica Vella, Alessandra Aloisi, Angelo Mandarino, Emanuela Mazzon, Riccardo Vigneri, Paolo Vigneri;
p73 tumor-suppressor activity is impaired in human thyroid cancer.
Cancer Res. 63:5829-5837(2003)

PubMed=15980887; DOI=10.1038/labinvest.3700306
Nobuki Nakamura, J. Aidan Carney, Long Jin, Sabine Kajita, Judit Pallares, He-Yu Zhang, Xiang Qian, Thomas Joseph Sebo, Lori A. Erickson, Ricardo V. Lloyd;
RASSF1A and NORE1A methylation and BRAFV600E mutations in thyroid tumors.
Lab. Invest. 85:1065-1075(2005)

PubMed=16778181; DOI=10.1158/0008-5472.CAN-06-0171
Elena Bonora, Anna Maria Porcelli, Giuseppe Gasparre, Annalisa Biondi, Anna Ghelli, Valerio Carelli, Alessandra Baracca, Giovanni Tallini, Andrea Martinuzzi, Giorgio Lenaz, Michela Rugolo, Giovanni Romeo;
Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III.
Cancer Res. 66:6087-6096(2006)

PubMed=17725429; DOI=10.1089/thy.2007.0097
Ana Margarida Meireles, Ana Preto, Ana Sofia Rocha, Ana Paula Rebocho, Valdemar Maximo, Isabel Pereira-Castro, Severina Moreira, Talia Feijao, Tiago Botelho, Ricardo Marques, Vitor Trovisco ...Show all 16 authors... , Luis Cirnes, Cintia Alves, Sergia Velho, Paula Soares, Manuel Sobrinho-Simoes; Show fewer authors
Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines.
Thyroid 17:707-715(2007)

PubMed=17804723; DOI=10.1158/0008-5472.CAN-06-4026
Wilma C.G. van Staveren, David Y. Weiss-Solis, Laurent Delys, Laurence Duprez, Guy Andry, Brigitte Franc, Gerry Thomas, Frederick Libert, Jacques-Emile Dumont, Vincent Detours, Carine Maenhaut;
Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype.
Cancer Res. 67:8113-8120(2007)

PubMed=18713817; DOI=10.1210/jc.2008-1102; PMCID=PMC2582569
Rebecca E. Schweppe, Joshua P. Klopper, Christopher T. Korch, Umarani Pugazhenthi, Miriam Benezra, Jeffrey A. Knauf, James Alexander Fagin, Laura A. Marlow, John Alton Copland 3rd, Robert Christian Smallridge, Bryan R. Haugen;
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.
J. Clin. Endocrinol. Metab. 93:4331-4341(2008)

PubMed=19087340; DOI=10.1186/1471-2407-8-371; PMCID=PMC2651892
Franclim Ricardo Ribeiro, Ana Margarida Meireles, Ana Sofia Rocha, Manuel R. Teixeira;
Conventional and molecular cytogenetics of human non-medullary thyroid carcinoma: characterization of eight cell line models and review of the literature on clinical samples.
BMC Cancer 8:371.1-371.11(2008)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=22087789; DOI=10.1186/1755-8166-4-26; PMCID=PMC3248874
Irena Maric, Silvia Viaggi, Paola Caria, Daniela Virginia Frau, Paolo Degan, Roberta Vanni;
Centrosomal and mitotic abnormalities in cell lines derived from papillary thyroid cancer harboring specific gene alterations.
Mol. Cytogenet. 4:26.1-26.8(2011)

PubMed=23162534; DOI=10.3389/fendo.2012.00133; PMCID=PMC3499787
Manuel Saiselet, Sebastien Floor, Maxime Tarabichi, Genevieve Dom, Aline Hebrant, Wilma C.G. van Staveren, Carine Maenhaut;
Thyroid cancer cell lines: an overview.
Front. Endocrinol. 3:133.1-133.9(2012)

PubMed=23833040; DOI=10.1210/jc.2013-2383; PMCID=PMC3763971
Inigo Landa, Ian Ganly, Timothy A. Chan, Norisato Mitsutake, Michiko Matsuse, Tihana Ibrahimpasic, Ronald A. Ghossein, James Alexander Fagin;
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Inigo Landa, Nikita Pozdeyev, Christopher T. Korch, Laura A. Marlow, Robert Christian Smallridge, John Alton Copland 3rd, Ying C. Henderson, Stephen Y. Lai, Gary L. Clayman, Naoyoshi Onoda, Aik-Choon Tan ...Show all 16 authors... , Maria E.R. Garcia-Rendueles, Jeffrey A. Knauf, Bryan R. Haugen, James Alexander Fagin, Rebecca E. Schweppe; Show fewer authors
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

PubMed=36599897; DOI=10.1038/s41598-023-27461-2; PMCID=PMC9813134
Tomomi Kurashige, Mika Shimamura, Koichiro Hamada, Michiko Matsuse, Norisato Mitsutake, Yuji Nagayama;
Characterization of metabolic reprogramming by metabolomics in the oncocytic thyroid cancer cell line XTC.UC1.
Sci. Rep. 13:149.1-149.11(2023)

Cross-references
Cell line collections (Providers) BCRJ; 0397
CLS; 305054
Millipore; SCC147
Cell line databases/resources TOKU-E; 4065
Anatomy/cell type resources BTO; BTO_0006508
Chemistry resources ChEMBL-Cells; CHEMBL3308064
ChEMBL-Targets; CHEMBL613836
PubChem_Cell_line; CVCL_6298
Encyclopedic resources Wikidata; Q54972844
Experimental variables resources EFO; EFO_0022629
Polymorphism and mutation databases Cosmic; 686571
Cosmic; 686572
Cosmic; 686728
Cosmic; 849969
Cosmic; 931238
Cosmic; 1021385
Cosmic; 1084277
Cosmic; 1132593
Cosmic; 1152124
Cosmic; 1237448
Cosmic; 1239954
Cosmic; 1280041
Cosmic; 2036695
Cosmic; 2054096
Cosmic; 2319845
Cosmic; 2613255
IARC_TP53; 25009
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number35