ID   TPC-1
AC   CVCL_6298
SY   TPC1
DR   BTO; BTO_0006508
DR   EFO; EFO_0022629
DR   BCRJ; 0397
DR   ChEMBL-Cells; CHEMBL3308064
DR   ChEMBL-Targets; CHEMBL613836
DR   CLS; 305054
DR   Cosmic; 686571
DR   Cosmic; 686572
DR   Cosmic; 686728
DR   Cosmic; 849969
DR   Cosmic; 931238
DR   Cosmic; 1021385
DR   Cosmic; 1084277
DR   Cosmic; 1132593
DR   Cosmic; 1152124
DR   Cosmic; 1237448
DR   Cosmic; 1239954
DR   Cosmic; 1280041
DR   Cosmic; 2036695
DR   Cosmic; 2054096
DR   Cosmic; 2319845
DR   Cosmic; 2613255
DR   IARC_TP53; 25009
DR   Millipore; SCC147
DR   PubChem_Cell_line; CVCL_6298
DR   TOKU-E; 4065
DR   Wikidata; Q54972844
RX   PubMed=2334411;
RX   PubMed=2516841;
RX   PubMed=2823470;
RX   PubMed=7491517;
RX   PubMed=11439348;
RX   PubMed=14522906;
RX   PubMed=15980887;
RX   PubMed=16778181;
RX   PubMed=17725429;
RX   PubMed=17804723;
RX   PubMed=18713817;
RX   PubMed=19087340;
RX   PubMed=21868764;
RX   PubMed=22087789;
RX   PubMed=23162534;
RX   PubMed=23833040;
RX   PubMed=30737244;
RX   PubMed=36599897;
CC   Population: Japanese.
CC   Sequence variation: Gene fusion; HGNC; HGNC:18782; CCDC6 + HGNC; HGNC:9967; RET; Name(s)=CCDC6-RET, RET/PTC1 (PubMed=7491517; PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Ala68fs (c.204_208delGGAGC); Zygosity=Homozygous (PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:11355; STAG2; Simple; p.Gln1089Ter (c.3265C>T); Zygosity=Heterozygous (PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=23833040; PubMed=30737244).
CC   Omics: Genomics; Mitochondrial genome sequencing.
CC   Omics: Metabolomics.
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
ST   Source(s): Millipore=SCC147; PubMed=18713817; PubMed=21868764; PubMed=30737244
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11,12
ST   D16S539: 9
ST   D18S51: 13,16
ST   D21S11: 30,31.2
ST   D3S1358: 16,17
ST   D5S818: 8,10
ST   D7S820: 11
ST   D8S1179: 11,17
ST   FGA: 20,21
ST   Penta D: 9,13
ST   Penta E: 18
ST   TH01: 9
ST   TPOX: 11
ST   vWA: 14,18
DI   NCIt; C4035; Thyroid gland papillary carcinoma
DI   ORDO; Orphanet_146; Differentiated thyroid carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Adult
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 35
CH   CVCL_6278 ! BHP 10-3
CH   CVCL_6282 ! BHP 18-21
CH   CVCL_6283 ! BHP 2-7
CH   CVCL_6285 ! BHP 7-13
CH   CVCL_9917 ! FB-2
CH   CVCL_E3IT ! HyCyte TPC-1-Luc
CH   CVCL_V277 ! RPTC-1
//
RX   PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280;
RA   Landa, Inigo
RA   Pozdeyev, Nikita
RA   Korch, Christopher T.
RA   Marlow, Laura A.
RA   Smallridge, Robert Christian
RA   Copland, John Alton 3rd
RA   Henderson, Ying C.
RA   Lai, Stephen Y.
RA   Clayman, Gary L.
RA   Onoda, Naoyoshi
RA   Tan, Aik-Choon
RA   Garcia-Rendueles, Maria E.R.
RA   Knauf, Jeffrey A.
RA   Haugen, Bryan R.
RA   Fagin, James Alexander
RA   Schweppe, Rebecca E.
RT   "Comprehensive genetic characterization of human thyroid cancer cell
RT   lines: a validated panel for preclinical studies.";
RL   Clin. Cancer Res. 25:3141-3151(2019).
//
RX   PubMed=23162534; DOI=10.3389/fendo.2012.00133; PMCID=PMC3499787;
RA   Saiselet, Manuel
RA   Floor, Sebastien
RA   Tarabichi, Maxime
RA   Dom, Genevieve
RA   Hebrant, Aline
RA   van Staveren, Wilma C.G.
RA   Maenhaut, Carine
RT   "Thyroid cancer cell lines: an overview.";
RL   Front. Endocrinol. 3:133.1-133.9(2012).
//
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662;
RA   Zhao, Mei
RA   Sano, Daisuke
RA   Pickering, Curtis R.
RA   Jasser, Samar A.
RA   Henderson, Ying C.
RA   Clayman, Gary L.
RA   Sturgis, Erich M.
RA   Ow, Thomas J.
RA   Lotan, Reuben
RA   Carey, Thomas E.
RA   Sacks, Peter G.
RA   Grandis, Jennifer Rubin
RA   Sidransky, David
RA   Heldin, Nils-Erik
RA   Myers, Jeffrey N.
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).
//
RX   PubMed=19087340; DOI=10.1186/1471-2407-8-371; PMCID=PMC2651892;
RA   Ribeiro, Franclim Ricardo
RA   Meireles, Ana Margarida
RA   Rocha, Ana Sofia
RA   Teixeira, Manuel R.
RT   "Conventional and molecular cytogenetics of human non-medullary
RT   thyroid carcinoma: characterization of eight cell line models and
RT   review of the literature on clinical samples.";
RL   BMC Cancer 8:371.1-371.11(2008).
//
RX   PubMed=2823470; DOI=10.1016/0042-6822(87)90171-1;
RA   Tanaka, Junji
RA   Ogura, Tsutomu
RA   Sato, Hiroshi
RA   Hatano, Motoichi
RT   "Establishment and biological characterization of an in vitro human
RT   cytomegalovirus latency model.";
RL   Virology 161:62-72(1987).
//
RX   PubMed=11439348; DOI=10.1038/sj.onc.1204531;
RA   Frasca, Francesco
RA   Vigneri, Paolo
RA   Vella, Veronica
RA   Vigneri, Riccardo
RA   Wang, Jean Y.-J.
RT   "Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile
RT   response to hepatocyte growth factor.";
RL   Oncogene 20:3845-3856(2001).
//
RX   PubMed=14522906;
RA   Frasca, Francesco
RA   Vella, Veronica
RA   Aloisi, Alessandra
RA   Mandarino, Angelo
RA   Mazzon, Emanuela
RA   Vigneri, Riccardo
RA   Vigneri, Paolo
RT   "p73 tumor-suppressor activity is impaired in human thyroid cancer.";
RL   Cancer Res. 63:5829-5837(2003).
//
RX   PubMed=36599897; DOI=10.1038/s41598-023-27461-2; PMCID=PMC9813134;
RA   Kurashige, Tomomi
RA   Shimamura, Mika
RA   Hamada, Koichiro
RA   Matsuse, Michiko
RA   Mitsutake, Norisato
RA   Nagayama, Yuji
RT   "Characterization of metabolic reprogramming by metabolomics in the
RT   oncocytic thyroid cancer cell line XTC.UC1.";
RL   Sci. Rep. 13:149.1-149.11(2023).
//
RX   PubMed=22087789; DOI=10.1186/1755-8166-4-26; PMCID=PMC3248874;
RA   Maric, Irena
RA   Viaggi, Silvia
RA   Caria, Paola
RA   Frau, Daniela Virginia
RA   Degan, Paolo
RA   Vanni, Roberta
RT   "Centrosomal and mitotic abnormalities in cell lines derived from
RT   papillary thyroid cancer harboring specific gene alterations.";
RL   Mol. Cytogenet. 4:26.1-26.8(2011).
//
RX   PubMed=23833040; DOI=10.1210/jc.2013-2383; PMCID=PMC3763971;
RA   Landa, Inigo
RA   Ganly, Ian
RA   Chan, Timothy A.
RA   Mitsutake, Norisato
RA   Matsuse, Michiko
RA   Ibrahimpasic, Tihana
RA   Ghossein, Ronald A.
RA   Fagin, James Alexander
RT   "Frequent somatic TERT promoter mutations in thyroid cancer: higher
RT   prevalence in advanced forms of the disease.";
RL   J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013).
//
RX   PubMed=18713817; DOI=10.1210/jc.2008-1102; PMCID=PMC2582569;
RA   Schweppe, Rebecca E.
RA   Klopper, Joshua P.
RA   Korch, Christopher T.
RA   Pugazhenthi, Umarani
RA   Benezra, Miriam
RA   Knauf, Jeffrey A.
RA   Fagin, James Alexander
RA   Marlow, Laura A.
RA   Copland, John Alton 3rd
RA   Smallridge, Robert Christian
RA   Haugen, Bryan R.
RT   "Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer
RT   cell lines reveals cross-contamination resulting in cell line
RT   redundancy and misidentification.";
RL   J. Clin. Endocrinol. Metab. 93:4331-4341(2008).
//
RX   PubMed=17804723; DOI=10.1158/0008-5472.CAN-06-4026;
RA   van Staveren, Wilma C.G.
RA   Weiss-Solis, David Y.
RA   Delys, Laurent
RA   Duprez, Laurence
RA   Andry, Guy
RA   Franc, Brigitte
RA   Thomas, Gerry
RA   Libert, Frederick
RA   Dumont, Jacques-Emile
RA   Detours, Vincent
RA   Maenhaut, Carine
RT   "Human thyroid tumor cell lines derived from different tumor types
RT   present a common dedifferentiated phenotype.";
RL   Cancer Res. 67:8113-8120(2007).
//
RX   PubMed=7491517; DOI=10.1016/S0039-6060(05)80108-4;
RA   Jossart, Gregg H.
RA   Greulich-Bode, Karin M.
RA   Siperstein, Allan E.
RA   Duh, Quan-Yang
RA   Clark, Orlo Herrick
RA   Weier, Heinz-Ulrich Gunter
RT   "Molecular and cytogenetic characterization of a t(1;10;21)
RT   translocation in the human papillary thyroid cancer cell line TPC-1
RT   expressing the ret/H4 chimeric transcript.";
RL   Surgery 118:1018-1023(1995).
//
RX   PubMed=2516841; DOI=10.1111/j.1349-7006.1989.tb01645.x; PMCID=PMC5917935;
RA   Ishizaka, Yukihito
RA   Itoh, Fumio
RA   Tahira, Tomoko
RA   Ikeda, Isuzu
RA   Ogura, Tsutomu
RA   Sugimura, Takashi
RA   Nagao, Minako
RT   "Presence of aberrant transcripts of ret proto-oncogene in a human
RT   papillary thyroid carcinoma cell line.";
RL   Jpn. J. Cancer Res. 80:1149-1152(1989).
//
RX   PubMed=15980887; DOI=10.1038/labinvest.3700306;
RA   Nakamura, Nobuki
RA   Carney, J. Aidan
RA   Jin, Long
RA   Kajita, Sabine
RA   Pallares, Judit
RA   Zhang, He-Yu
RA   Qian, Xiang
RA   Sebo, Thomas Joseph
RA   Erickson, Lori A.
RA   Lloyd, Ricardo V.
RT   "RASSF1A and NORE1A methylation and BRAFV600E mutations in thyroid
RT   tumors.";
RL   Lab. Invest. 85:1065-1075(2005).
//
RX   PubMed=2334411; DOI=10.1016/0006-291X(90)92335-W;
RA   Ishizaka, Yukihito
RA   Ushijima, Toshikazu
RA   Sugimura, Takashi
RA   Nagao, Minako
RT   "cDNA cloning and characterization of ret activated in a human
RT   papillary thyroid carcinoma cell line.";
RL   Biochem. Biophys. Res. Commun. 168:402-408(1990).
//
RX   PubMed=17725429; DOI=10.1089/thy.2007.0097;
RA   Meireles, Ana Margarida
RA   Preto, Ana
RA   Rocha, Ana Sofia
RA   Rebocho, Ana Paula
RA   Maximo, Valdemar
RA   Pereira-Castro, Isabel
RA   Moreira, Severina
RA   Feijao, Talia
RA   Botelho, Tiago
RA   Marques, Ricardo
RA   Trovisco, Vitor
RA   Cirnes, Luis
RA   Alves, Cintia
RA   Velho, Sergia
RA   Soares, Paula
RA   Sobrinho-Simoes, Manuel
RT   "Molecular and genotypic characterization of human thyroid follicular
RT   cell carcinoma-derived cell lines.";
RL   Thyroid 17:707-715(2007).
//
RX   PubMed=16778181; DOI=10.1158/0008-5472.CAN-06-0171;
RA   Bonora, Elena
RA   Porcelli, Anna Maria
RA   Gasparre, Giuseppe
RA   Biondi, Annalisa
RA   Ghelli, Anna
RA   Carelli, Valerio
RA   Baracca, Alessandra
RA   Tallini, Giovanni
RA   Martinuzzi, Andrea
RA   Lenaz, Giorgio
RA   Rugolo, Michela
RA   Romeo, Giovanni
RT   "Defective oxidative phosphorylation in thyroid oncocytic carcinoma is
RT   associated with pathogenic mitochondrial DNA mutations affecting
RT   complexes I and III.";
RL   Cancer Res. 66:6087-6096(2006).
//