Cellosaurus cell line HyCyte TPC-1-Luc (CVCL

Cross-references
Cell line name	HyCyte TPC-1-Luc
Synonyms	Luciferase Reporter TPC-1 Cell Line
Accession	CVCL_E3IT
Resource Identification Initiative	To cite this cell line use: HyCyte TPC-1-Luc (RRID:CVCL_E3IT)
Comments	Population: Japanese. Doubling time: 24-48 hours (Hysigen=TCH-C381L). Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase. Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR). Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Sequence variations	Gene fusion; HGNC; HGNC:18782; CCDC6 + HGNC; HGNC:9967; RET; Name(s)=CCDC6-RET, RET/PTC1 (from parent cell line). Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Ala68fs (c.204_208delGGAGC); Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:11355; STAG2; Simple; p.Gln1089Ter (c.3265C>T); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (from parent cell line).
Disease	Thyroid gland papillary carcinoma (NCIt: C4035) Differentiated thyroid carcinoma (ORDO: Orphanet_146)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_6298 (TPC-1)
Sex of cell	Female
Age at sampling	Adult
Category	Cancer cell line
Cell line collections (Providers)	Hysigen; TCH-C381L
Entry history
Entry creation	19-Dec-2024
Last entry update	14-Aug-2025
Version number	2