| Cell line name |
A375-R |
|---|
| Accession |
CVCL_6234 |
|---|
| Resource Identification Initiative |
To cite this cell line use: A375-R (RRID:CVCL_6234) |
|---|
| Comments |
Population: Caucasian.
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511. |
|---|
| Sequence variations |
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
|
|---|
| Disease |
Amelanotic melanoma (NCIt: C3802) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_0132 (A-375) |
|---|
| Sex of cell |
Female |
|---|
| Age at sampling |
54Y |
|---|
| Category |
Cancer cell line |
|---|
| Web pages |
Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=A375-R |
|---|
| Publications | PubMed=3260254; DOI=10.4049/jimmunol.141.2.512
Yukito Ichinose, Ouahid Bakouche, Jerry Y. Tsao, Isaiah Joshua Fidler;
Tumor necrosis factor and IL-1 associated with plasma membranes of activated human monocytes lyse monokine-sensitive but not monokine-resistant tumor cells whereas viable activated monocytes lyse both.
J. Immunol. 141:512-518(1988) |
|---|
| Cross-references |
|---|
| Cell line databases/resources |
cancercelllines; CVCL_6234
|
|---|
| Encyclopedic resources |
Wikidata; Q54606861
|
|---|
| Entry history |
|---|
| Entry creation | 04-Apr-2012 |
|---|
| Last entry update | 10-Apr-2025 |
|---|
| Version number | 22 |
|---|
