ID   A375-R
AC   CVCL_6234
DR   cancercelllines; CVCL_6234
DR   Wikidata; Q54606861
RX   PubMed=3260254;
WW   Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=A375-R
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0132 ! A-375
SX   Female
AG   54Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 22
//
RX   PubMed=3260254; DOI=10.4049/jimmunol.141.2.512;
RA   Ichinose, Yukito
RA   Bakouche, Ouahid
RA   Tsao, Jerry Y.
RA   Fidler, Isaiah Joshua
RT   "Tumor necrosis factor and IL-1 associated with plasma membranes of
RT   activated human monocytes lyse monokine-sensitive but not
RT   monokine-resistant tumor cells whereas viable activated monocytes lyse
RT   both.";
RL   J. Immunol. 141:512-518(1988).
//