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Cellosaurus OCUT-1 (CVCL_6017)

[Text version]
Cell line name OCUT-1
Synonyms Ocut-1; OCUT1; Osaka City University Thyroid-1
Accession CVCL_6017
Resource Identification Initiative To cite this cell line use: OCUT-1 (RRID:CVCL_6017)
Comments Population: Japanese.
Doubling time: 34 hours (PubMed=12210034).
Omics: Transcriptomics; Microarray.
Miscellaneous: Cell line has been lost (PubMed=24357248).
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=23833040; PubMed=30737244).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=30737244).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Homozygous; Note=In promoter (PubMed=23833040).
Disease Thyroid gland anaplastic carcinoma (NCIt: C3878)
Anaplastic thyroid carcinoma (ORDO: Orphanet_142)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_B5GE (OCUT-1C)CVCL_B5GF (OCUT-1F)
Sex of cell Female
Age at sampling 74Y
Category Cancer cell line
STR profile Source(s): PubMed=30737244

Markers:
AmelogeninX
CSF1PO12,13
D3S135815
D5S8189,13
D7S82011,13
D8S117915,17
D13S3178
D16S53910,12
D18S5119,20
D21S1130
FGA21,22
TH016,9
TPOX8,11
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=12210034; DOI=10.1002/jso.10122
Kana Ogisawa, Naoyoshi Onoda, Tetsuro Ishikawa, Chiemi Takenaka, Masaaki Inaba, Yoshinari Ogawa, Kosei Hirakawa-Y.S. Chung;
Establishment and characterization of OCUT-1, an undifferentiated thyroid cancer cell line expressing high level of telomerase.
J. Surg. Oncol. 80:197-203(2002)

PubMed=23833040; DOI=10.1210/jc.2013-2383; PMCID=PMC3763971
Inigo Landa, Ian Ganly, Timothy A. Chan, Norisato Mitsutake, Michiko Matsuse, Tihana Ibrahimpasic, Ronald A. Ghossein, James Alexander Fagin;
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=24357248; DOI=10.1007/s00268-013-2409-7
Naoyoshi Onoda, Masanori Nakamura, Naoki Aomatsu, Satoru Noda, Shinichiro Kashiwagi, Kosei Hirakawa;
Establishment, characterization and comparison of seven authentic anaplastic thyroid cancer cell lines retaining clinical features of the original tumors.
World J. Surg. 38:688-695(2014)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Inigo Landa, Nikita Pozdeyev, Christopher T. Korch, Laura A. Marlow, Robert Christian Smallridge, John Alton Copland 3rd, Ying C. Henderson, Stephen Y. Lai, Gary L. Clayman, Naoyoshi Onoda, Aik-Choon Tan ...Show all 16 authors... , Maria E.R. Garcia-Rendueles, Jeffrey A. Knauf, Bryan R. Haugen, James Alexander Fagin, Rebecca E. Schweppe; Show fewer authors
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6017
Anatomy/cell type resources BTO; BTO_0004846
Encyclopedic resources Wikidata; Q54931845
Polymorphism and mutation databases Cosmic; 1152123
Cosmic; 1239960
Cosmic; 1280045
Cosmic; 1507372
Cosmic; 1533548
Cosmic; 1536125
Cosmic; 1889003
Cosmic; 2054107
Cosmic; 2319852
Cosmic; 2791081
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number22