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Cellosaurus OCUT-1C (CVCL_B5GE)

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Cell line name OCUT-1C
Synonyms Osaka City University Thyroid-1C
Accession CVCL_B5GE
Resource Identification Initiative To cite this cell line use: OCUT-1C (RRID:CVCL_B5GE)
Comments Population: Japanese.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=24357248).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Homozygous; Note=In promoter (from parent cell line).
Disease Thyroid gland anaplastic carcinoma (NCIt: C3878)
Anaplastic thyroid carcinoma (ORDO: Orphanet_142)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6017 (OCUT-1)
Sex of cell Female
Age at sampling 74Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB1891

Markers:
AmelogeninX
CSF1PO12,13
D5S8189,13
D7S82011,13
D13S3178
D16S53910,12
TH016,9
TPOX8,11
vWA16,18

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Publications

PubMed=24357248; DOI=10.1007/s00268-013-2409-7
Naoyoshi Onoda, Masanori Nakamura, Naoki Aomatsu, Satoru Noda, Shinichiro Kashiwagi, Kosei Hirakawa;
Establishment, characterization and comparison of seven authentic anaplastic thyroid cancer cell lines retaining clinical features of the original tumors.
World J. Surg. 38:688-695(2014)

PubMed=26137260; DOI=10.3892/mco.2015.496; PMCID=PMC4471583
Naoyoshi Onoda, Masanori Nakamura, Naoki Aomatsu, Satoru Noda, Shinichiro Kashiwagi, Kento Kurata, Shinya Uchino, Kosei Hirakawa;
Significant cytostatic effect of everolimus on a gefitinib-resistant anaplastic thyroid cancer cell line harboring PI3KCA gene mutation.
Mol. Clin. Oncol. 3:522-526(2015)

Cross-references
Cell line collections (Providers) JCRB; JCRB1891
Cell line databases/resources cancercelllines; CVCL_B5GE
Encyclopedic resources Wikidata; Q110433122
Entry history
Entry creation16-Dec-2021
Last entry update19-Dec-2024
Version number7