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Cellosaurus SVG-A (CVCL_5G13)

[Text version]
Cell line name SVG-A
Accession CVCL_5G13
Resource Identification Initiative To cite this cell line use: SVG-A (RRID:CVCL_5G13)
Comments Characteristics: Used to study trinucleotide repeat (TNR) expansion as these cells support expansiosns in culture.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pSVori-).
Omics: Transcriptomics; Microarray.
Caution: In contrast to SVG p12 (Cellosaurus=CVCL_3797), this cell line is not contaminated with BK polyomavirus (PubMed=24760884).
Derived from site: In situ; Fetal brain; UBERON=UBERON_0006238.
Cell type: Astrocyte; CL=CL_0000127.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5G14 (SVG)
Children:
CVCL_C3HJ (SVG-A CHMP1A null)CVCL_VP18 (SVG-A Msh3-/-)CVCL_IM78 (SVGR2)
Sex of cell Male
Age at sampling 8-12FW
Category Transformed cell line
Publications

PubMed=11517388; DOI=10.1080/13550280152058816
Becky Schweighardt, Joseph T.C. Shieh, Walter J. Atwood;
CD4/CXCR4-independent infection of human astrocytes by a T-tropic strain of HIV-1.
J. Neurovirol. 7:155-162(2001)

PubMed=14517064; DOI=10.1016/S0042-6822(03)00389-1
Gretchen Vogel Gee, Kate Manley, Walter J. Atwood;
Derivation of a JC virus-resistant human glial cell line: implications for the identification of host cell factors that determine viral tropism.
Virology 314:101-109(2003)

PubMed=16945950; DOI=10.1093/nar/gkl614; PMCID=PMC1636369
Brian T. Farrell, Robert S. Lahue;
CAG*CTG repeat instability in cultured human astrocytes.
Nucleic Acids Res. 34:4495-4505(2006)

PubMed=17555786; DOI=10.1016/j.virol.2007.05.016; PMCID=PMC2062566
Kate Manley, Gretchen Vogel Gee, Carl P. Simkevich, John Michael Sedivy, Walter J. Atwood;
Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression.
Virology 366:394-404(2007)

PubMed=17881653; DOI=10.1093/hmg/ddm270
David A. Claassen, Robert S. Lahue;
Expansions of CAG.CTG repeats in immortalized human astrocytes.
Hum. Mol. Genet. 16:3088-3096(2007)

PubMed=24760884; DOI=10.1128/JVI.00696-14; PMCID=PMC4054427
Stian Henriksen, Garth Daryl Tylden, Alexis Dumoulin, Biswa Nath Sharma, Hans H. Hirsch, Christine Hanssen Rinaldo;
The human fetal glial cell line SVG p12 contains infectious BK polyomavirus.
J. Virol. 88:7556-7568(2014)

PubMed=25288626; DOI=10.1128/JVI.01600-14; PMCID=PMC4248886
Michael W. Ferenczy, Eugene O. Major;
Contamination of SVG p12 cells with BK polyomavirus occurred after deposit in the American Type Culture Collection.
J. Virol. 88:12928-12929(2014)

PubMed=28973443; DOI=10.1093/nar/gkx650; PMCID=PMC5622409
Norma Keogh, Kara Y. Chan, Guo-Min Li, Robert S. Lahue;
MutSbeta abundance and Msh3 ATP hydrolysis activity are important drivers of CTG*CAG repeat expansions.
Nucleic Acids Res. 45:10068-10078(2017)

PubMed=30044992; DOI=10.1016/j.celrep.2018.06.100; PMCID=PMC6178983
Michael Edward Coulter, Cristina M. Dorobantu, Gerrald A. Lodewijk, Francois Delalande, Sarah Cianferani, Vijay S. Ganesh, Richard S. Smith, Elaine Teng-Tim Lim, C. Shan Xu, Song Pang, Eric T. Wong, Hart G.W. Lidov, Monica L. Calicchio ...Show all 25 authors... , Edward Yang, Dilenny M. Gonzalez, Thorsten M. Schlaeger, Ganeshwaran H. Mochida, Harald Hess, Wei-Chung Allen Lee, Maria K. Lehtinen, Tomas Leopold Kirchhausen, David Haussler, Frank M.J. Jacobs, Raphael Gaudin, Christopher A. Walsh; Show fewer authors
The ESCRT-III protein CHMP1A mediates secretion of sonic hedgehog on a distinctive subtype of extracellular vesicles.
Cell Rep. 24:973-986.e8(2018)

Cross-references
Cell line collections (Providers) CancerTools; 153563
Ximbio; 153563
Anatomy/cell type resources BTO; BTO_0006555
Encyclopedic resources Wikidata; Q54971010
Gene expression databases GEO; GSM189708
GEO; GSM189709
GEO; GSM189710
GEO; GSM189714
GEO; GSM189715
GEO; GSM189716
Entry history
Entry creation14-Dec-2015
Last entry update10-Apr-2025
Version number16