ID   SVG-A
AC   CVCL_5G13
DR   BTO; BTO_0006555
DR   CancerTools; 153563
DR   GEO; GSM189708
DR   GEO; GSM189709
DR   GEO; GSM189710
DR   GEO; GSM189714
DR   GEO; GSM189715
DR   GEO; GSM189716
DR   Wikidata; Q54971010
DR   Ximbio; 153563
RX   PubMed=11517388;
RX   PubMed=14517064;
RX   PubMed=16945950;
RX   PubMed=17555786;
RX   PubMed=17881653;
RX   PubMed=24760884;
RX   PubMed=25288626;
RX   PubMed=28973443;
RX   PubMed=30044992;
CC   Characteristics: Used to study trinucleotide repeat (TNR) expansion as these cells support expansiosns in culture.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pSVori-).
CC   Omics: Transcriptomics; Microarray.
CC   Caution: In contrast to SVG p12 (Cellosaurus=CVCL_3797), this cell line is not contaminated with BK polyomavirus (PubMed=24760884).
CC   Derived from site: In situ; Fetal brain; UBERON=UBERON_0006238.
CC   Cell type: Astrocyte; CL=CL_0000127.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_5G14 ! SVG
SX   Male
AG   8-12FW
CA   Transformed cell line
DT   Created: 14-12-15; Last updated: 10-04-25; Version: 16
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RX   PubMed=11517388; DOI=10.1080/13550280152058816;
RA   Schweighardt B., Shieh J.T.C., Atwood W.J.;
RT   "CD4/CXCR4-independent infection of human astrocytes by a T-tropic
RT   strain of HIV-1.";
RL   J. Neurovirol. 7:155-162(2001).
//
RX   PubMed=14517064; DOI=10.1016/S0042-6822(03)00389-1;
RA   Gee G.V., Manley K., Atwood W.J.;
RT   "Derivation of a JC virus-resistant human glial cell line:
RT   implications for the identification of host cell factors that
RT   determine viral tropism.";
RL   Virology 314:101-109(2003).
//
RX   PubMed=16945950; DOI=10.1093/nar/gkl614; PMCID=PMC1636369;
RA   Farrell B.T., Lahue R.S.;
RT   "CAG*CTG repeat instability in cultured human astrocytes.";
RL   Nucleic Acids Res. 34:4495-4505(2006).
//
RX   PubMed=17555786; DOI=10.1016/j.virol.2007.05.016; PMCID=PMC2062566;
RA   Manley K., Gee G.V., Simkevich C.P., Sedivy J.M., Atwood W.J.;
RT   "Microarray analysis of glial cells resistant to JCV infection
RT   suggests a correlation between viral infection and inflammatory
RT   cytokine gene expression.";
RL   Virology 366:394-404(2007).
//
RX   PubMed=17881653; DOI=10.1093/hmg/ddm270;
RA   Claassen D.A., Lahue R.S.;
RT   "Expansions of CAG.CTG repeats in immortalized human astrocytes.";
RL   Hum. Mol. Genet. 16:3088-3096(2007).
//
RX   PubMed=24760884; DOI=10.1128/JVI.00696-14; PMCID=PMC4054427;
RA   Henriksen S., Tylden G.D., Dumoulin A., Sharma B.N., Hirsch H.H.,
RA   Rinaldo C.H.;
RT   "The human fetal glial cell line SVG p12 contains infectious BK
RT   polyomavirus.";
RL   J. Virol. 88:7556-7568(2014).
//
RX   PubMed=25288626; DOI=10.1128/JVI.01600-14; PMCID=PMC4248886;
RA   Ferenczy M.W., Major E.O.;
RT   "Contamination of SVG p12 cells with BK polyomavirus occurred after
RT   deposit in the American Type Culture Collection.";
RL   J. Virol. 88:12928-12929(2014).
//
RX   PubMed=28973443; DOI=10.1093/nar/gkx650; PMCID=PMC5622409;
RA   Keogh N., Chan K.Y., Li G.-M., Lahue R.S.;
RT   "MutSbeta abundance and Msh3 ATP hydrolysis activity are important
RT   drivers of CTG*CAG repeat expansions.";
RL   Nucleic Acids Res. 45:10068-10078(2017).
//
RX   PubMed=30044992; DOI=10.1016/j.celrep.2018.06.100; PMCID=PMC6178983;
RA   Coulter M.E., Dorobantu C.M., Lodewijk G.A., Delalande F.,
RA   Cianferani S., Ganesh V.S., Smith R.S., Lim E.T.-T., Xu C.S., Pang S.,
RA   Wong E.T., Lidov H.G.W., Calicchio M.L., Yang E., Gonzalez D.M.,
RA   Schlaeger T.M., Mochida G.H., Hess H., Lee W.-C.A., Lehtinen M.K.,
RA   Kirchhausen T.L., Haussler D., Jacobs F.M.J., Gaudin R., Walsh C.A.;
RT   "The ESCRT-III protein CHMP1A mediates secretion of sonic hedgehog on
RT   a distinctive subtype of extracellular vesicles.";
RL   Cell Rep. 24:973-986.e8(2018).
//