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Cellosaurus COMMA-D (CVCL_5731)

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Cell line name COMMA-D
Synonyms Comma-D; COMMA D; Comma 1D; Comma-1D; COMMA-1D; COMMA1D; CD
Accession CVCL_5731
Resource Identification Initiative To cite this cell line use: COMMA-D (RRID:CVCL_5731)
Comments Characteristics: Can functionally differentiate to preneoplastic and neoplastic phenotypes (PubMed=36630696).
Omics: Transcriptomics; RNAseq; Single cell.
Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: BALB/c.
Hierarchy Children:
CVCL_5717 (CDNR1)CVCL_5718 (CDNR2)CVCL_5719 (CDNR4)
CVCL_E1I1 (CID 9)CVCL_JZ81 (COMMA-1D/PDK1)CVCL_5732 (COMMA-D beta)
CVCL_E1II (COMMA-D clone DB-1)CVCL_U227 (COMMA-D/MME)CVCL_5G82 (COMMA-F)
CVCL_5G83 (COMMA-T)CVCL_0288 (HC11)CVCL_U228 (PS-BME-L6)
CVCL_U229 (PS-BME-L7)
Sex of cell Female
Age at sampling 1Y
Category Spontaneously immortalized cell line
Publications

PubMed=6587390; DOI=10.1073/pnas.81.12.3756; PMCID=PMC345298
Keith G. Danielson, Carol J. Oborn, Elisa M. Durban, Janet S. Butel, Daniel Medina;
Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vitro.
Proc. Natl. Acad. Sci. U.S.A. 81:3756-3760(1984)

PubMed=24259225; DOI=10.1007/BF02917600
Daniel Medina, David Morrison, Carol J. Oborn;
Selenium retention and inhibition of cell growth in mouse mammary epithelial cell lines in vitro.
Biol. Trace Elem. Res. 8:19-35(1985)

PubMed=2423737; DOI=10.1093/jnci/76.6.1143
Daniel Medina, Carol J. Oborn, Frances S. Kittrell, Robert L. Ullrich;
Properties of mouse mammary epithelial cell lines characterized by in vivo transplantation and in vitro immunocytochemical methods.
J. Natl. Cancer Inst. 76:1143-1156(1986)

PubMed=3653254; DOI=10.1016/0014-4827(87)90105-4
Daniel Medina, Ming-Liang Li, Carol J. Oborn, Mina J. Bissell;
Casein gene expression in mouse mammary epithelial cell lines: dependence upon extracellular matrix and cell type.
Exp. Cell Res. 172:192-203(1987)

PubMed=36630696; DOI=10.3389/fgene.2022.894597; PMCID=PMC9237515
Arpit Dave, Erin Nekritz, Daniel Charytonowicz, Michael Beaumont, Melissa Smith, Kristin G. Beaumont, Jose Silva, Robert P. Sebra;
Integration of single-cell transcriptomics with a high throughput functional screening assay to resolve cell type, growth kinetics, and stemness heterogeneity within the Comma-1D cell line.
Front. Genet. 13:894597.1-894597.20(2022)

Cross-references
Encyclopedic resources Wikidata; Q54814228
Experimental variables resources EFO; EFO_0022829
Gene expression databases GEO; GSE182589
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number16