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Cellosaurus HC11 (CVCL_0288)

[Text version]
Cell line name HC11
Synonyms HC-11; HC11 Mammary Epithelium
Accession CVCL_0288
Resource Identification Initiative To cite this cell line use: HC11 (RRID:CVCL_0288)
Comments Doubling time: ~50-80 hours (DSMZ=ACC-780).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: BALB/c.
Hierarchy Parent: CVCL_5731 (COMMA-D)
Children:
CVCL_5G41 (HC11-BC20)CVCL_5G42 (HC11-BC44)CVCL_0R13 (HC11-C24)
CVCL_0R14 (HC11-C4)CVCL_B4FA (HC11/MV7)CVCL_B4FB (HC11/Twist)
CVCL_B4FC (HC11/Wnt-1)
Sex of cell Female
Age at sampling 1Y
Category Spontaneously immortalized cell line
Web pages Info; -; -; https://cpb-us-e2.wpmucdn.com/faculty.sites.uci.edu/dist/0/349/files/2014/03/HC11-Culture-KW-BG.pdf
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-143.html
Publications

PubMed=3416834; DOI=10.1002/j.1460-2075.1988.tb03048.x; PMCID=PMC454494
Ball R.K., Friis R.R., Schoenenberger C.A., Doppler W., Groner B.
Prolactin regulation of beta-casein gene expression and of a cytosolic 120-kd protein in a cloned mouse mammary epithelial cell line.
EMBO J. 7:2089-2095(1988)

PubMed=12702582
Howe L.R., Watanabe O., Leonard J., Brown A.M.C.
Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation.
Cancer Res. 63:1906-1913(2003)

PubMed=19523745; DOI=10.1016/j.diff.2009.05.003
Perotti C., Wiedl T., Florin L., Reuter H., Moffat S., Silbermann M., Hahn M., Angel P., Shemanko C.S.
Characterization of mammary epithelial cell line HC11 using the NIA 15k gene array reveals potential regulators of the undifferentiated and differentiated phenotypes.
Differentiation 78:269-282(2009)

Cross-references
Cell line collections (Providers) ABM; T0672
ATCC; CRL-3062
CLS; 305050
DSMZ; ACC-780
Cell line databases/resources MCCL; MCC:0000178
CCRID; 3101MOUSCSP5037
DSMZCellDive; ACC-780
Lonza; 967
Anatomy/cell type resources BTO; BTO_0003892
Encyclopedic resources Wikidata; Q54881476
Experimental variables resources EFO; EFO_0006414
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27