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Cellosaurus HC11 (CVCL_0288)

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Cell line name HC11
Synonyms HC-11; HC11 Mammary Epithelium
Accession CVCL_0288
Resource Identification Initiative To cite this cell line use: HC11 (RRID:CVCL_0288)
Comments Doubling time: ~50-80 hours (DSMZ=ACC-780).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: BALB/c.
Hierarchy Parent: CVCL_5731 (COMMA-D)
Children:
CVCL_5G41 (HC11-BC20)CVCL_5G42 (HC11-BC44)CVCL_0R13 (HC11-C24)
CVCL_0R14 (HC11-C4)CVCL_B4FA (HC11/MV7)CVCL_B4FB (HC11/Twist)
CVCL_B4FC (HC11/Wnt-1)
Sex of cell Female
Age at sampling 1Y
Category Spontaneously immortalized cell line
Web pages Info; -; -; https://cpb-us-e2.wpmucdn.com/faculty.sites.uci.edu/dist/0/349/files/2014/03/HC11-Culture-KW-BG.pdf
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-143.html
Publications

PubMed=3416834; DOI=10.1002/j.1460-2075.1988.tb03048.x; PMCID=PMC454494
Roland K. Ball, Robert Reaney Friis, Cora A. Schoenenberger, Wolfgang Doppler, Bernd Groner;
Prolactin regulation of beta-casein gene expression and of a cytosolic 120-kd protein in a cloned mouse mammary epithelial cell line.
EMBO J. 7:2089-2095(1988)

PubMed=12702582
Louise R. Howe, Osamu Watanabe, James Leonard, Anthony M.C. Brown;
Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation.
Cancer Res. 63:1906-1913(2003)

PubMed=19523745; DOI=10.1016/j.diff.2009.05.003
Christian Perotti, Thomas Wiedl, Lore Florin, Hendrik Reuter, S. Moffat, Marleen Silbermann, Moritz Hahn, Peter Angel, Carrie Simone Shemanko;
Characterization of mammary epithelial cell line HC11 using the NIA 15k gene array reveals potential regulators of the undifferentiated and differentiated phenotypes.
Differentiation 78:269-282(2009)

Cross-references
Cell line collections (Providers) ABM; T0672
ATCC; CRL-3062
CLS; 305050
DSMZ; ACC-780
Cell line databases/resources MCCL; MCC:0000178
CCRID; 3101MOUSCSP5037
DSMZCellDive; ACC-780
Lonza; 967
Anatomy/cell type resources BTO; BTO_0003892
Encyclopedic resources Wikidata; Q54881476
Experimental variables resources EFO; EFO_0006414
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27