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Cellosaurus CH-157MN (CVCL_5723)

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Cell line name CH-157MN
Synonyms CH157-MN; CH-157-MN; CH-157 MN; CH157MN
Accession CVCL_5723
Resource Identification Initiative To cite this cell line use: CH-157MN (RRID:CVCL_5723)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Doubling time: 22 hours (PubMed=25984343); 1 day (PubMed=34850056).
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; shRNA library screening.
Caution: Indicated as originating from a 41 year old female patient in PubMed=7714613, from a 59 year old in PubMed=10083766 and from a 55 year old in PubMed=18261772.
Derived from site: In situ; Brain, meninges; UBERON=UBERON_0010743.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Unspecified (DepMap=ACH-000025).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=28552950).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.5
Native American0
East Asian, North2.54
East Asian, South0
South Asian0.15
European, North57.82
European, South38.99
Disease Meningioma (NCIt: C3230)
Meningioma (ORDO: Orphanet_2495)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_HA68 (CH-157MN-LucNeo)
Sex of cell Female
Age at sampling 41Y
Category Cancer cell line
Publications

PubMed=7714613; DOI=10.3171/jns.1995.82.5.0864
Jui-Chang Tsai, Corey Keith Goldman, George Yancey Gillespie;
Vascular endothelial growth factor in human glioma cell lines: induced secretion by EGF, PDGF-BB, and bFGF.
J. Neurosurg. 82:864-873(1995)

PubMed=10083766
Jui-Chang Tsai, Yi-Yun Hsiao, Lee-Jene Teng, Chia-Tung Shun, Chin-Tin Chen, Corey Keith Goldman, Ming-Chien Kao;
Regulation of vascular endothelial growth factor secretion in human meningioma cells.
J. Formos. Med. Assoc. 98:111-117(1999)

PubMed=18261772; DOI=10.1016/j.surneu.2007.06.031
Brian Thomas Ragel, William Tupper Couldwell, David L. Gillespie, Merideth Michele Wendland, Kum Whang, Randy Lynn Jensen;
A comparison of the cell lines used in meningioma research.
Surg. Neurol. 70:295-307(2008)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=28552950; DOI=10.1371/journal.pone.0178322; PMCID=PMC5446134
Yu Mei, Wen-Ya Linda Bi, Noah F. Greenwald, Nathalie Yvonne Rachel Agar, Rameen Beroukhim, Gavin P. Dunn, Ian F. Dunn;
Genomic profile of human meningioma cell lines.
PLoS ONE 12:e0178322.1-e0178322.12(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=34850056; DOI=10.1093/jnen/nlab111; PMCID=PMC8716066
Erik Janos Uhlmann, Rosalia Rabinovsky, Hemant Varma, Rachid El Fatimy, Ekkehard M. Kasper, Justin M. Moore, Rafael A. Vega, Ajith J. Thomas, Ronald L. Alterman, Martina Stippler, Matthew P. Anderson ...Show all 14 authors... , Erik N. Uhlmann, Franciele Cristina Kipper, Anna M. Krichevsky; Show fewer authors
Tumor-derived cell culture model for the investigation of meningioma biology.
J. Neuropathol. Exp. Neurol. 80:1117-1124(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5723
Cell_Model_Passport; SIDM01543
DepMap; ACH-000025
Biological sample resources BioSample; SAMN10988423
Chemistry resources PharmacoDB; CH157MN_195_2019
Encyclopedic resources Wikidata; Q54811594
Polymorphism and mutation databases Cosmic; 2516046
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number24