ID   CH-157MN
AC   CVCL_5723
SY   CH157-MN; CH-157-MN; CH-157 MN; CH157MN
DR   BioSample; SAMN10988423
DR   cancercelllines; CVCL_5723
DR   Cell_Model_Passport; SIDM01543
DR   Cosmic; 2516046
DR   DepMap; ACH-000025
DR   PharmacoDB; CH157MN_195_2019
DR   Wikidata; Q54811594
RX   PubMed=7714613;
RX   PubMed=10083766;
RX   PubMed=18261772;
RX   PubMed=25984343;
RX   PubMed=28552950;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=34850056;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Doubling time: 22 hours (PubMed=25984343); 1 day (PubMed=34850056).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Unspecified (DepMap).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=28552950).
CC   Omics: Deep exome analysis.
CC   Omics: shRNA library screening.
CC   Genome ancestry: African=0.5%; Native American=0%; East Asian, North=2.54%; East Asian, South=0%; South Asian=0.15%; European, North=57.82%; European, South=38.99% (PubMed=30894373).
CC   Caution: Indicated as originating from a 41 year old female patient in PubMed=7714613, from a 59 year old in PubMed=10083766 and from a 55 year old in PubMed=18261772.
CC   Derived from site: In situ; Brain, meninges; UBERON=UBERON_0010743.
DI   NCIt; C3230; Meningioma
DI   ORDO; Orphanet_2495; Meningioma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   41Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 21
//
RX   PubMed=7714613; DOI=10.3171/jns.1995.82.5.0864;
RA   Tsai J.-C., Goldman C.K., Gillespie G.Y.;
RT   "Vascular endothelial growth factor in human glioma cell lines:
RT   induced secretion by EGF, PDGF-BB, and bFGF.";
RL   J. Neurosurg. 82:864-873(1995).
//
RX   PubMed=10083766;
RA   Tsai J.-C., Hsiao Y.-Y., Teng L.-J., Shun C.-T., Chen C.-T.,
RA   Goldman C.K., Kao M.-C.;
RT   "Regulation of vascular endothelial growth factor secretion in human
RT   meningioma cells.";
RL   J. Formos. Med. Assoc. 98:111-117(1999).
//
RX   PubMed=18261772; DOI=10.1016/j.surneu.2007.06.031;
RA   Ragel B.T., Couldwell W.T., Gillespie D.L., Wendland M.M., Whang K.,
RA   Jensen R.L.;
RT   "A comparison of the cell lines used in meningioma research.";
RL   Surg. Neurol. 70:295-307(2008).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35;
RA   Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S.,
RA   East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H.,
RA   Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M.,
RA   Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S.,
RA   Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D.,
RA   Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C.,
RA   Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P.,
RA   Golub T.R., Root D.E., Hahn W.C.;
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035-140035(2014).
//
RX   PubMed=28552950; DOI=10.1371/journal.pone.0178322;
RA   Mei Y., Bi W.-Y.L., Greenwald N.F., Agar N.Y., Beroukhim R., Dunn G.P.,
RA   Dunn I.F.;
RT   "Genomic profile of human meningioma cell lines.";
RL   PLoS ONE 12:E0178322-E0178322(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=34850056; DOI=10.1093/jnen/nlab111;
RA   Uhlmann E.J., Rabinovsky R., Varma H., El Fatimy R., Kasper E.M.,
RA   Moore J.M., Vega R.A., Thomas A.J., Alterman R.L., Stippler M.,
RA   Anderson M.P., Uhlmann E.N., Kipper F.C., Krichevsky A.M.;
RT   "Tumor-derived cell culture model for the investigation of meningioma
RT   biology.";
RL   J. Neuropathol. Exp. Neurol. 80:1117-1124(2021).
//