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Cellosaurus A375-SM (CVCL_5649)

[Text version]
Cell line name A375-SM
Synonyms A-375SM; A375SM
Accession CVCL_5649
Resource Identification Initiative To cite this cell line use: A375-SM (RRID:CVCL_5649)
Comments Population: Caucasian.
Characteristics: Highly metastatic. Established from a tumor obtained in nude mice injected with the parent cell line.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): KCLB=80004


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Schackert G., Price J.E., Zhang R.-D., Bucana C.D., Itoh K., Fidler I.J.
Regional growth of different human melanomas as metastases in the brain of nude mice.
Am. J. Pathol. 136:95-102(1990)

Zhang R.-D., Price J.E., Schackert G., Itoh K., Fidler I.J.
Malignant potential of cells isolated from lymph node or brain metastases of melanoma patients and implications for prognosis.
Cancer Res. 51:2029-2035(1991)

PubMed=7648437; DOI=10.1089/jir.1995.15.81
Singh R.K., Gutman M., Radinsky R.
Heterogeneity of cytokine and growth factor gene expression in human melanoma cells with different metastatic potentials.
J. Interferon Cytokine Res. 15:81-87(1995)

PubMed=22323893; DOI=10.3109/10623329609024685
Sriramarao P., Bourdon M.A.
Melanoma cell invasive and metastatic potential correlates with endothelial cell reorganization and tenascin expression.
Endothelium 4:85-97(1996)

Cell line collections (Providers) KCLB; 80004
Cell line databases/resources cancercelllines; CVCL_5649
Anatomy/cell type resources BTO; BTO:0003985
Chemistry resources ChEMBL-Cells; CHEMBL4513103
ChEMBL-Targets; CHEMBL4513121
PubChem_Cell_line; CVCL_5649
Encyclopedic resources Wikidata; Q54606863
Polymorphism and mutation databases Cosmic; 932716
Cosmic; 1238111
Cosmic; 1303033
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number24