| Cell line name |
A375-SM |
| Synonyms |
A-375SM; A375SM |
| Accession |
CVCL_5649 |
| Resource Identification Initiative |
To cite this cell line use: A375-SM (RRID:CVCL_5649) |
| Comments |
Population: Caucasian. Characteristics: Highly metastatic. Established from a tumor obtained in nude mice injected with the parent cell line. Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511. |
| Sequence variations |
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
|
| Disease |
Amelanotic melanoma (NCIt: C3802) |
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
| Hierarchy |
Parent: CVCL_0132 (A-375) |
| Sex of cell |
Female |
| Age at sampling |
54Y |
| Category |
Cancer cell line |
| STR profile |
Source(s): KCLB=80004
Markers: Run an STR similarity search on this cell line |
| Publications | PubMed=2297053; PMCID=PMC1877453 Gabriele Schackert, Janet E. Price, Ruo-Dan Zhang, Corazon D. Bucana, Kyogo Itoh, Isaiah Joshua Fidler; Regional growth of different human melanomas as metastases in the brain of nude mice. Am. J. Pathol. 136:95-102(1990) PubMed=1826230 Ruo-Dan Zhang, Janet E. Price, Gabriele Schackert, Kyogo Itoh, Isaiah Joshua Fidler; Malignant potential of cells isolated from lymph node or brain metastases of melanoma patients and implications for prognosis. Cancer Res. 51:2029-2035(1991) PubMed=7648437; DOI=10.1089/jir.1995.15.81 Rakesh K. Singh, Mordechai Gutman, Robert Radinsky; Heterogeneity of cytokine and growth factor gene expression in human melanoma cells with different metastatic potentials. J. Interferon Cytokine Res. 15:81-87(1995) PubMed=22323893; DOI=10.3109/10623329609024685; PMCID=PMC3274348 Pragada Sriramarao, Mario A. Bourdon; Melanoma cell invasive and metastatic potential correlates with endothelial cell reorganization and tenascin expression. Endothelium 4:85-97(1996) |
| Cross-references |
| Cell line collections (Providers) |
KCLB; 80004
|
| Cell line databases/resources |
cancercelllines; CVCL_5649
|
| Anatomy/cell type resources |
BTO; BTO_0003985
|
| Chemistry resources |
ChEMBL-Cells; CHEMBL4513103
ChEMBL-Targets; CHEMBL4513121
PubChem_Cell_line; CVCL_5649
|
| Encyclopedic resources |
Wikidata; Q54606863
|
| Polymorphism and mutation databases |
Cosmic; 932716
Cosmic; 1238111
Cosmic; 1303033
|
| Entry history |
| Entry creation | 04-Apr-2012 |
| Last entry update | 19-Dec-2024 |
| Version number | 26 |
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