ID   A375-SM
AC   CVCL_5649
SY   A-375SM; A375SM
DR   BTO; BTO:0003985
DR   cancercelllines; CVCL_5649
DR   ChEMBL-Cells; CHEMBL4513103
DR   ChEMBL-Targets; CHEMBL4513121
DR   Cosmic; 932716
DR   Cosmic; 1238111
DR   Cosmic; 1303033
DR   KCLB; 80004
DR   PubChem_Cell_line; CVCL_5649
DR   Wikidata; Q54606863
RX   PubMed=1826230;
RX   PubMed=2297053;
RX   PubMed=7648437;
RX   PubMed=22323893;
CC   Population: Caucasian.
CC   Characteristics: Highly metastatic. Established from a tumor obtained in nude mice injected with the parent cell line.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
ST   Source(s): KCLB=80004
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D3S1358: 15,17
ST   D5S818: 12
ST   D7S820: 9
ST   FGA: 20,23
ST   TH01: 8
ST   TPOX: 8,10
ST   vWA: 16,17
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0132 ! A-375
SX   Female
AG   54Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 24
//
RX   PubMed=1826230;
RA   Zhang R.-D., Price J.E., Schackert G., Itoh K., Fidler I.J.;
RT   "Malignant potential of cells isolated from lymph node or brain
RT   metastases of melanoma patients and implications for prognosis.";
RL   Cancer Res. 51:2029-2035(1991).
//
RX   PubMed=2297053;
RA   Schackert G., Price J.E., Zhang R.-D., Bucana C.D., Itoh K.,
RA   Fidler I.J.;
RT   "Regional growth of different human melanomas as metastases in the
RT   brain of nude mice.";
RL   Am. J. Pathol. 136:95-102(1990).
//
RX   PubMed=7648437; DOI=10.1089/jir.1995.15.81;
RA   Singh R.K., Gutman M., Radinsky R.;
RT   "Heterogeneity of cytokine and growth factor gene expression in human
RT   melanoma cells with different metastatic potentials.";
RL   J. Interferon Cytokine Res. 15:81-87(1995).
//
RX   PubMed=22323893; DOI=10.3109/10623329609024685;
RA   Sriramarao P., Bourdon M.A.;
RT   "Melanoma cell invasive and metastatic potential correlates with
RT   endothelial cell reorganization and tenascin expression.";
RL   Endothelium 4:85-97(1996).
//