Cellosaurus logo
expasy logo

Cellosaurus VACO 411 (CVCL_5176)

[Text version]
Cell line name VACO 411
Synonyms Vaco 411; VACO-411; VACO411; V411
Accession CVCL_5176
Resource Identification Initiative To cite this cell line use: VACO 411 (RRID:CVCL_5176)
Comments Characteristics: Established from a late passage nude mouse xenograft of the parent cell line (PubMed=8132740).
Microsatellite instability: Stable (MSS) (PubMed=25926053).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5175 (VACO 235)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): PubMed=25926053

Markers:
AmelogeninX
CSF1PO11,12
D5S81813
D7S8209,11
D13S3179,12
D16S53911,12
D21S1129,32.2
TH019
TPOX8
vWA15

Run an STR similarity search on this cell line
Publications

PubMed=8132740; DOI=10.1172/JCI117048; PMCID=PMC294021
Sanford David Markowitz, Lois Lemmermann Myeroff, Mark J. Cooper, June L. Traicoff, Mary E. Kochera, James D. Lutterbaugh, Margaret Swiriduk, James K.V. Willson;
A benign cultured colon adenoma bears three genetically altered colon cancer oncogenes, but progresses to tumorigenicity and transforming growth factor-beta independence without inactivating the p53 tumor suppressor gene.
J. Clin. Invest. 93:1005-1013(1994)

PubMed=7761852; DOI=10.1126/science.7761852
Sanford David Markowitz, Jing Wang, Lois Lemmermann Myeroff, Ramon Parsons, Lu-Zhe Sun, James D. Lutterbaugh, Robert S. Fan, Elizabeth Zborowska, Kenneth Wayne Kinzler, Bert Vogelstein, Michael G. Brattain, James K.V. Willson;
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability.
Science 268:1336-1338(1995)

PubMed=12595761; DOI=10.1007/BF02256060
June L. Traicoff, Sumudra Periyasamy, Michael G. Brattain, William M. Grady, Graham Casey;
Reconstitution of TGF-beta sensitivity in the VACO-411 human colon carcinoma line by somatic cell fusion with MCF-7.
J. Biomed. Sci. 10:253-259(2003)

PubMed=25926053; DOI=10.1038/ncomms8002
Enzo Medico, Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Emanuele Valtorta, Giorgio Corti, Michela Buscarino, Claudio Isella, Simona Lamba, Barbara Martinoglio, Silvio Veronese ...Show all 19 authors... , Salvatore Siena, Andrea Sartore-Bianchi, Marco Beccuti, Marcella Mottolese, Michael Linnebacher, Francesca Cordero, Federica Di Nicolantonio, Alberto Bardelli; Show fewer authors
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

Cross-references
Cell line databases/resources ColonAtlas; VACO411
Encyclopedic resources Wikidata; Q54992726
Gene expression databases GEO; GSM1448221
Polymorphism and mutation databases Cosmic; 736334
IARC_TP53; 23620
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number14