ID   VACO 411
AC   CVCL_5176
SY   Vaco 411; VACO-411; VACO411; V411
DR   ColonAtlas; VACO411
DR   Cosmic; 736334
DR   GEO; GSM1448221
DR   IARC_TP53; 23620
DR   Wikidata; Q54992726
RX   PubMed=7761852;
RX   PubMed=8132740;
RX   PubMed=12595761;
RX   PubMed=25926053;
CC   Characteristics: Established from a late passage nude mouse xenograft of the parent cell line (PubMed=8132740).
CC   Microsatellite instability: Stable (MSS) (PubMed=25926053).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
ST   Source(s): PubMed=25926053
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 9,12
ST   D16S539: 11,12
ST   D21S11: 29,32.2
ST   D5S818: 13
ST   D7S820: 9,11
ST   TH01: 9
ST   TPOX: 8
ST   vWA: 15
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_5175 ! VACO 235
SX   Female
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 14
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RX   PubMed=7761852; DOI=10.1126/science.7761852;
RA   Markowitz S.D., Wang J., Myeroff L.L., Parsons R., Sun L.-Z.,
RA   Lutterbaugh J.D., Fan R.S., Zborowska E., Kinzler K.W., Vogelstein B.,
RA   Brattain M.G., Willson J.K.V.;
RT   "Inactivation of the type II TGF-beta receptor in colon cancer cells
RT   with microsatellite instability.";
RL   Science 268:1336-1338(1995).
//
RX   PubMed=8132740; DOI=10.1172/JCI117048; PMCID=PMC294021;
RA   Markowitz S.D., Myeroff L.L., Cooper M.J., Traicoff J.L., Kochera M.E.,
RA   Lutterbaugh J.D., Swiriduk M., Willson J.K.V.;
RT   "A benign cultured colon adenoma bears three genetically altered colon
RT   cancer oncogenes, but progresses to tumorigenicity and transforming
RT   growth factor-beta independence without inactivating the p53 tumor
RT   suppressor gene.";
RL   J. Clin. Invest. 93:1005-1013(1994).
//
RX   PubMed=12595761; DOI=10.1007/BF02256060;
RA   Traicoff J.L., Periyasamy S., Brattain M.G., Grady W.M., Casey G.;
RT   "Reconstitution of TGF-beta sensitivity in the VACO-411 human colon
RT   carcinoma line by somatic cell fusion with MCF-7.";
RL   J. Biomed. Sci. 10:253-259(2003).
//
RX   PubMed=25926053; DOI=10.1038/ncomms8002;
RA   Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G.,
RA   Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S.,
RA   Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M.,
RA   Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.;
RT   "The molecular landscape of colorectal cancer cell lines unveils
RT   clinically actionable kinase targets.";
RL   Nat. Commun. 6:7002.1-7002.10(2015).
//