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Cellosaurus SNU-719 (CVCL_5086)

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Cell line name SNU-719
Synonyms SNU719; NCI-SNU-719
Accession CVCL_5086
Resource Identification Initiative To cite this cell line use: SNU-719 (RRID:CVCL_5086)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Seoul National University (SNU) cell line collection.
Population: Korean.
Virology: Contains a complete EBV genome (strain SNU-719) which has been sequenced (PubMed=26889033).
Doubling time: 43 hours (PubMed=29435981).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Stomach; UBERON=UBERON_0000945.
Sequence variations
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly34Val (c.101G>T); ClinVar=VCV000017582; Zygosity=Heterozygous (DepMap=ACH-000898).
  • Mutation; HGNC; HGNC:7029; MET; Simple; p.Asp153Ala (c.458A>C); Zygosity=Heterozygous (PubMed=29435981; DepMap=ACH-000898).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Homozygous (DepMap=ACH-000898).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro104Arg (c.311C>G); ClinVar=VCV001480334; Zygosity=Heterozygous (DepMap=ACH-000898).
  • Mutation; HGNC; HGNC:667; RHOA; Simple; p.Ala61Val (c.182C>T); Zygosity=Heterozygous (PubMed=34466148; DepMap=ACH-000898).
  • Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=9033653).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*24:02,24:02
HLA-BB*07:02,52:01
HLA-CC*07:02,12:02
Class II
HLA-DQDQB1*05:01,05:01
HLA-DRDRB1*01:01,15:02

Source: PubMed=26589293
Class I
HLA-AA*24:02,24:02
HLA-BB*07:02,52:01
HLA-CC*07:02,12:02
Class II
HLA-DQDQA1*05:02,05:02
DQB1*05:01,05:01
HLA-DRDRB1*01:01,15:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American1.31
East Asian, North60.01
East Asian, South38.67
South Asian0
European, North0
European, South0
Disease Gastric tubular adenocarcinoma (NCIt: C5473)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_L052 (SNU-719-5FU)CVCL_L053 (SNU-719-DOX)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): KCLB=00719; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO12
D3S135815
D5S81811,12
D7S82010,11
D8S117912
D13S31710,11
D16S5399,10
D18S5113,15
D21S1129,30
FGA21,23
Penta D10,11
Penta E11,16
TH017,9
TPOX8,9
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=9033653; DOI=10.1002/(SICI)1097-0215(19970207)70:4<443::AID-IJC12>3.0.CO;2-G
Jae-Gahb Park, Han-Kwang Yang, Woo-Ho Kim, June-Key Chung, Myung-Soo Kang, Jae-Ho Lee, Jae Hwan Oh, Hyun-Sook Park, Kyong-Sook Yeo, Shin Hyuck Kang, Sang-Yong Song ...Show all 15 authors... , Yun Kyung Kang, Yung-Jue Bang, Yong Il Kim, Jin-Pok Kim; Show fewer authors
Establishment and characterization of human gastric carcinoma cell lines.
Int. J. Cancer 70:443-449(1997)

PubMed=10812166; DOI=10.1016/S0165-4608(99)00217-4
Yong-Hyuck Chun, Joon-Il Kil, Young-Suk Suh, Seung-Han Kim, Hyun Kim, Sun-Hwa Park;
Characterization of chromosomal aberrations in human gastric carcinoma cell lines using chromosome painting.
Cancer Genet. Cytogenet. 119:18-25(2000)

PubMed=15016554; DOI=10.1016/j.virol.2003.12.005
Sang Taek Oh, Jung Seon Seo, Uk Yeol Moon, Kyeong Hee Kang, Dong-Jik Shin, Sungjoo Kim Yoon, Woo-Ho Kim, Jae-Gahb Park, Suk Kyeong Lee;
A naturally derived gastric cancer cell line shows latency I Epstein-Barr virus infection closely resembling EBV-associated gastric cancer.
Virology 320:330-336(2004)

PubMed=15723654; DOI=10.1111/j.1349-7006.2005.00016.x; PMCID=PMC11160020
Hisashi Takada, Issei Imoto, Hitoshi Tsuda, Itaru Sonoda, Takashi Ichikura, Hidetaka Mochizuki, Takeshi Okanoue, Johji Inazawa;
Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.
Cancer Sci. 96:100-110(2005)

PubMed=19956504; DOI=10.4143/crt.2005.37.1.1; PMCID=PMC2785416
Ja-Lok Ku, Jae-Gahb Park;
Biology of SNU cell lines.
Cancer Res. Treat. 37:1-19(2005)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24807215; DOI=10.1038/ncomms4830; PMCID=PMC4024760
Jin-Feng Liu, Mark L. McCleland, Eric W. Stawiski, Florian Gnad, Oleg Mayba, Peter M. Haverty, Steffen Durinck, Ying-Jiun Chen, Christiaan Klijn, Suchit Jhunjhunwala, Michael Lawrence ...Show all 30 authors... , Han-Bin Liu, Yi-Nan Wan, Vivek S. Chopra, Murat Burat Yaylaoglu, Wen-Lin Yuan, Connie Ha, Houston N. Gilbert, Jens Reeder, Gregoire Pau, Jeremy Stinson, Howard M. Stern, Gerard Manning, Thomas D. Wu, Richard M. Neve, Frederic J. de Sauvage, Zora Modrusan, Somasekar Seshagiri, Ron Firestein, Ze-Min Zhang; Show fewer authors
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Nat. Commun. 5:3830.1-3830.8(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=26889033; DOI=10.1128/JVI.00060-16; PMCID=PMC4836357
Teru Kanda, Yuki Furuse, Hitoshi Oshitani, Tohru Kiyono;
Highly efficient CRISPR/Cas9-mediated cloning and functional characterization of gastric cancer-derived Epstein-Barr virus strains.
J. Virol. 90:4383-4393(2016)

PubMed=29435981; DOI=10.1002/ijc.31304
Hyun Jeong Kim, Sun Kyoung Kang, Woo Sun Kwon, Tae Soo Kim, Inhye Jeong, Hei-Cheul Jeung, Michael Kragh, Ivan D. Horak, Hyun Cheol Chung, Sun Young Rha;
Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor.
Int. J. Cancer 143:151-159(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=34466148; DOI=10.3892/ol.2021.12996; PMCID=PMC8387854
Naoki Ikari, Akiko Serizawa, Etsuko Tanji, Masakazu Yamamoto, Toru Furukawa;
Analysis of RHOA mutations and their significance in the proliferation and transcriptome of digestive tract cancer cells.
Oncol. Lett. 22:735.1-735.7(2021)

Cross-references
Cell line collections (Providers) KCLB; 00719
Cell line databases/resources cancercelllines; CVCL_5086
Cell_Model_Passport; SIDM01450
CGH-DB; 129-1
CGH-DB; 9017-4
DepMap; ACH-000898
Anatomy/cell type resources BTO; BTO_0006482
Biological sample resources BioSample; SAMN03473188
BioSample; SAMN10988060
Chemistry resources PharmacoDB; SNU719_1479_2019
Encyclopedic resources Wikidata; Q54955255
Experimental variables resources EFO; EFO_0006760
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
GEO; GSM552375
GEO; GSM888727
Polymorphism and mutation databases Cosmic; 685594
Cosmic; 848144
Cosmic; 869512
Cosmic; 921603
Cosmic; 1090458
Cosmic; 1294959
Cosmic; 1528880
Cosmic; 2646594
Cosmic; 2807652
IARC_TP53; 30169
LiGeA; CCLE_869
Progenetix; CVCL_5086
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number37