ID   SNU-719
AC   CVCL_5086
SY   SNU719; NCI-SNU-719
DR   BTO; BTO_0006482
DR   EFO; EFO_0006760
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   BioSample; SAMN03473188
DR   BioSample; SAMN10988060
DR   cancercelllines; CVCL_5086
DR   Cell_Model_Passport; SIDM01450
DR   CGH-DB; 129-1
DR   CGH-DB; 9017-4
DR   CLS; 305636
DR   Cosmic; 685594
DR   Cosmic; 848144
DR   Cosmic; 869512
DR   Cosmic; 921603
DR   Cosmic; 1090458
DR   Cosmic; 1294959
DR   Cosmic; 1528880
DR   Cosmic; 2646594
DR   Cosmic; 2807652
DR   DepMap; ACH-000898
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001002554
DR   GEO; GSM552375
DR   GEO; GSM888727
DR   IARC_TP53; 30169
DR   KCLB; 00719
DR   LiGeA; CCLE_869
DR   PharmacoDB; SNU719_1479_2019
DR   Progenetix; CVCL_5086
DR   Wikidata; Q54955255
RX   PubMed=9033653;
RX   PubMed=10812166;
RX   PubMed=15016554;
RX   PubMed=15723654;
RX   PubMed=19956504;
RX   PubMed=22460905;
RX   PubMed=24807215;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=25960936;
RX   PubMed=26589293;
RX   PubMed=26889033;
RX   PubMed=29435981;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31978347;
RX   PubMed=34466148;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: Seoul National University (SNU) cell line collection.
CC   Population: Korean.
CC   Virology: Contains a complete EBV genome (strain SNU-719) which has been sequenced (PubMed=26889033).
CC   Doubling time: 43 hours (PubMed=29435981).
CC   HLA typing: A*24:02,24:02; B*07:02,52:01; C*07:02,12:02; DQB1*05:01,05:01; DRB1*01:01,15:02 (PubMed=25960936).
CC   HLA typing: A*24:02,24:02; B*07:02,52:01; C*07:02,12:02; DQA1*05:02,05:02; DQB1*05:01,05:01; DRB1*01:01,15:02 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly34Val (c.101G>T); ClinVar=VCV000017582; Zygosity=Heterozygous (DepMap=ACH-000898).
CC   Sequence variation: Mutation; HGNC; HGNC:7029; MET; Simple; p.Asp153Ala (c.458A>C); Zygosity=Heterozygous (PubMed=29435981; DepMap=ACH-000898).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Homozygous (DepMap=ACH-000898).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro104Arg (c.311C>G); ClinVar=VCV001480334; Zygosity=Heterozygous (DepMap=ACH-000898).
CC   Sequence variation: Mutation; HGNC; HGNC:667; RHOA; Simple; p.Ala61Val (c.182C>T); Zygosity=Heterozygous (PubMed=34466148; DepMap=ACH-000898).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=9033653).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0%; Native American=1.31%; East Asian, North=60.01%; East Asian, South=38.67%; South Asian=0%; European, North=0%; European, South=0% (PubMed=30894373).
CC   Derived from site: In situ; Stomach; UBERON=UBERON_0000945.
ST   Source(s): KCLB=00719; PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 10,11
ST   D16S539: 9,10
ST   D18S51: 13,15
ST   D21S11: 29,30
ST   D3S1358: 15
ST   D5S818: 11,12
ST   D7S820: 10,11
ST   D8S1179: 12
ST   FGA: 21,23
ST   Penta D: 10,11
ST   Penta E: 11,16
ST   TH01: 7,9
ST   TPOX: 8,9
ST   vWA: 16,18
DI   NCIt; C5473; Gastric tubular adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   53Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 31-03-26; Version: 38
CH   CVCL_L052 ! SNU-719-5FU
CH   CVCL_L053 ! SNU-719-DOX
//
RX   PubMed=29435981; DOI=10.1002/ijc.31304;
RA   Kim, Hyun Jeong
RA   Kang, Sun Kyoung
RA   Kwon, Woo Sun
RA   Kim, Tae Soo
RA   Jeong, Inhye
RA   Jeung, Hei-Cheul
RA   Kragh, Michael
RA   Horak, Ivan D.
RA   Chung, Hyun Cheol
RA   Rha, Sun Young
RT   "Forty-nine gastric cancer cell lines with integrative genomic
RT   profiling for development of c-MET inhibitor.";
RL   Int. J. Cancer 143:151-159(2018).
//
RX   PubMed=15016554; DOI=10.1016/j.virol.2003.12.005;
RA   Oh, Sang Taek
RA   Seo, Jung Seon
RA   Moon, Uk Yeol
RA   Kang, Kyeong Hee
RA   Shin, Dong-Jik
RA   Yoon, Sungjoo Kim
RA   Kim, Woo-Ho
RA   Park, Jae-Gahb
RA   Lee, Suk Kyeong
RT   "A naturally derived gastric cancer cell line shows latency I
RT   Epstein-Barr virus infection closely resembling EBV-associated gastric
RT   cancer.";
RL   Virology 320:330-336(2004).
//
RX   PubMed=24807215; DOI=10.1038/ncomms4830; PMCID=PMC4024760;
RA   Liu, Jin-Feng
RA   McCleland, Mark L.
RA   Stawiski, Eric W.
RA   Gnad, Florian
RA   Mayba, Oleg
RA   Haverty, Peter M.
RA   Durinck, Steffen
RA   Chen, Ying-Jiun
RA   Klijn, Christiaan
RA   Jhunjhunwala, Suchit
RA   Lawrence, Michael
RA   Liu, Han-Bin
RA   Wan, Yi-Nan
RA   Chopra, Vivek S.
RA   Yaylaoglu, Murat Burat
RA   Yuan, Wen-Lin
RA   Ha, Connie
RA   Gilbert, Houston N.
RA   Reeder, Jens
RA   Pau, Gregoire
RA   Stinson, Jeremy
RA   Stern, Howard M.
RA   Manning, Gerard
RA   Wu, Thomas D.
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Modrusan, Zora
RA   Seshagiri, Somasekar
RA   Firestein, Ron
RA   Zhang, Ze-Min
RT   "Integrated exome and transcriptome sequencing reveals ZAK isoform
RT   usage in gastric cancer.";
RL   Nat. Commun. 5:3830.1-3830.8(2014).
//
RX   PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254;
RA   Nusinow, David Paul
RA   Szpyt, John
RA   Ghandi, Mahmoud
RA   Rose, Christopher M.
RA   McDonald, E. Robert 3rd
RA   Kalocsay, Marian
RA   Jane-Valbuena, Judit
RA   Gelfand, Ellen T.
RA   Schweppe, Devin Karl
RA   Jedrychowski, Mark P.
RA   Golji, Javad
RA   Porter, Dale A.
RA   Rejtar, Tomas
RA   Wang, Y. Karen
RA   Kryukov, Gregory V.
RA   Stegmeier, Frank
RA   Erickson, Brian K.
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RA   Gygi, Steven P.
RT   "Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
RL   Cell 180:387-402.e16(2020).
//
RX   PubMed=10812166; DOI=10.1016/S0165-4608(99)00217-4;
RA   Chun, Yong-Hyuck
RA   Kil, Joon-Il
RA   Suh, Young-Suk
RA   Kim, Seung-Han
RA   Kim, Hyun
RA   Park, Sun-Hwa
RT   "Characterization of chromosomal aberrations in human gastric
RT   carcinoma cell lines using chromosome painting.";
RL   Cancer Genet. Cytogenet. 119:18-25(2000).
//
RX   PubMed=34466148; DOI=10.3892/ol.2021.12996; PMCID=PMC8387854;
RA   Ikari, Naoki
RA   Serizawa, Akiko
RA   Tanji, Etsuko
RA   Yamamoto, Masakazu
RA   Furukawa, Toru
RT   "Analysis of RHOA mutations and their significance in the
RT   proliferation and transcriptome of digestive tract cancer cells.";
RL   Oncol. Lett. 22:735.1-735.7(2021).
//
RX   PubMed=9033653; DOI=10.1002/(SICI)1097-0215(19970207)70:4<443::AID-IJC12>3.0.CO;2-G;
RA   Park, Jae-Gahb
RA   Yang, Han-Kwang
RA   Kim, Woo-Ho
RA   Chung, June-Key
RA   Kang, Myung-Soo
RA   Lee, Jae-Ho
RA   Oh, Jae Hwan
RA   Park, Hyun-Sook
RA   Yeo, Kyong-Sook
RA   Kang, Shin Hyuck
RA   Song, Sang-Yong
RA   Kang, Yun Kyung
RA   Bang, Yung-Jue
RA   Kim, Yong Il
RA   Kim, Jin-Pok
RT   "Establishment and characterization of human gastric carcinoma cell
RT   lines.";
RL   Int. J. Cancer 70:443-449(1997).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26889033; DOI=10.1128/JVI.00060-16; PMCID=PMC4836357;
RA   Kanda, Teru
RA   Furuse, Yuki
RA   Oshitani, Hitoshi
RA   Kiyono, Tohru
RT   "Highly efficient CRISPR/Cas9-mediated cloning and functional
RT   characterization of gastric cancer-derived Epstein-Barr virus
RT   strains.";
RL   J. Virol. 90:4383-4393(2016).
//
RX   PubMed=15723654; DOI=10.1111/j.1349-7006.2005.00016.x; PMCID=PMC11160020;
RA   Takada, Hisashi
RA   Imoto, Issei
RA   Tsuda, Hitoshi
RA   Sonoda, Itaru
RA   Ichikura, Takashi
RA   Mochizuki, Hidetaka
RA   Okanoue, Takeshi
RA   Inazawa, Johji
RT   "Screening of DNA copy-number aberrations in gastric cancer cell lines
RT   by array-based comparative genomic hybridization.";
RL   Cancer Sci. 96:100-110(2005).
//
RX   PubMed=19956504; DOI=10.4143/crt.2005.37.1.1; PMCID=PMC2785416;
RA   Ku, Ja-Lok
RA   Park, Jae-Gahb
RT   "Biology of SNU cell lines.";
RL   Cancer Res. Treat. 37:1-19(2005).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura Eleanor
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981;
RA   Boegel, Sebastian
RA   Lower, Martin
RA   Bukur, Thomas
RA   Sahin, Ugur
RA   Castle, John C.
RT   "A catalog of HLA type, HLA expression, and neo-epitope candidates in
RT   human cancer cell lines.";
RL   OncoImmunology 3:e954893.1-e954893.12(2014).
//