Cellosaurus cell line RPMI-8226/MR4 (CVCL

Cellosaurus RPMI-8226/MR4 (CVCL_4V90)

[Text version]

Cell line name

RPMI-8226/MR4

Synonyms

RPMI 8226/MR4; 8226/MR4

Accession

CVCL_4V90

Resource Identification Initiative

To cite this cell line use: RPMI-8226/MR4 (RRID:CVCL_4V90)

Comments

Population: African American.
Characteristics: Produces IgG lambda (from parent cell line).
Selected for resistance to: ChEBI; CHEBI_50729; Mitoxantrone.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Plasma cell; CL=CL_0000786.

Sequence variations

Gene fusion; HGNC; HGNC:5722; IGKJ4 + HGNC; HGNC:5783; IGKV2-28; Name(s)=IGKV2-28-IGKJ4 (from parent cell line).
Gene fusion; HGNC; HGNC:5865; IGLJ3 + HGNC; HGNC:5888; IGLV2-14; Name(s)=IGLV2-14-IGLJ3 (from parent cell line).
Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr751Ile (c.2252C>T); ClinVar=VCV000177773; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; HGNC:12033; TRAF3; Simple; p.Lys191Leufs*60; Zygosity=Unspecified (from parent cell line).

Disease

Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_0014 (RPMI-8226)
Children:

CVCL_0509 (RPMI-8226/MR20)

Sex of cell

Male

Age at sampling

61Y