| Cell line name |
MP41 |
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| Accession |
CVCL_4D12 |
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| Resource Identification Initiative |
To cite this cell line use: MP41 (RRID:CVCL_4D12) |
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| Comments |
Characteristics: Established from a patient-derived xenograft (PubMed=24994677).
Doubling time: 41 hours (PubMed=24994677).
Omics: Proteomics.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Eye, uvea; UBERON=UBERON_0001768.
Cell type: Epithelial cell; CL=CL_0000066. |
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| Sequence variations |
- Mutation; HGNC; HGNC:4379; GNA11; Simple; p.Gln209Leu (c.626A>T); ClinVar=VCV000376002; Zygosity=Heterozygous (PubMed=24994677; DepMap=ACH-002010).
- Mutation; HGNC; HGNC:11100; SMARCA4; Simple; p.Thr910Met (c.2729C>T); ClinVar=VCV000438790; Zygosity=Heterozygous (DepMap=ACH-002010).
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| Disease |
Uveal melanoma (NCIt: C7712) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Children:
|
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| Sex of cell |
Female |
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| Age at sampling |
49Y |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): ATCC=CRL-3297; PubMed=24994677
Markers:| Amelogenin | X |
| CSF1PO | 9,10 |
| D5S818 | 10,13 |
| D7S820 | 8.3,9,9.3,10,10.1,11 (ATCC=CRL-3297)
9,10 (PubMed=24994677) |
| D13S317 | 11,14 |
| D16S539 | 13 |
| D21S11 | 30.2,31.2 |
| TH01 | 6,7 |
| TPOX | 8,11 |
| vWA | 15,18 |
Run an STR similarity search on this cell line |
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| Publications | PubMed=24994677; DOI=10.1016/j.molonc.2014.06.004; PMCID=PMC5528590
Nabil Amirouchene-Angelozzi, Fariba Nemati, David Gentien, Andre Nicolas, Amaury Dumont, Guillaume Carita, Jacques Camonis, Laurence Desjardins, Nathalie Cassoux, Sophie Piperno-Neumann, Pascale Mariani ...Show all 14 authors... , Xavier Sastre-Garau, Didier Decaudin, Sergio Roman-Roman; Show fewer authors
Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target.
Mol. Oncol. 8:1508-1520(2014) PubMed=39042403; DOI=10.1167/iovs.65.8.37; PMCID=PMC11268447
Maria Chiara Gelmi, Arnoud H. de Ru, Peter A. van Veelen, Rayman T.N. Tjokrodirijo, Marc-Henri Stern, Alexandre Houy, Robert M. Verdijk, T.H. Khanh Vu, Bruce R. Ksander, Jolanda Vaarwater, Emine Kilic ...Show all 13 authors... , Erwin Brosens, Martine Johanna Jager; Show fewer authors
Protein and mRNA expression in uveal melanoma cell lines are related to GNA and BAP1 mutation status.
Invest. Ophthalmol. Vis. Sci. 65:37-37(2024) |
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| Cross-references |
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| Cell line collections (Providers) |
ATCC; CRL-3297
|
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| Cell line databases/resources |
cancercelllines; CVCL_4D12
DepMap; ACH-002010
|
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| Chemistry resources |
ChEMBL-Cells; CHEMBL4879544
|
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| Encyclopedic resources |
Wikidata; Q54906429
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| Proteomic databases |
PRIDE; PXD051055
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| Entry history |
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| Entry creation | 22-Sep-2015 |
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| Last entry update | 22-Oct-2026 |
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| Version number | 15 |
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