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Cellosaurus MP41 (CVCL_4D12)

[Text version]
Cell line name MP41
Accession CVCL_4D12
Resource Identification Initiative To cite this cell line use: MP41 (RRID:CVCL_4D12)
Comments Characteristics: Established from a patient-derived xenograft (PubMed=24994677).
Doubling time: 41 hours (PubMed=24994677).
Omics: Proteomics.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Eye, uvea; UBERON=UBERON_0001768.
Cell type: Epithelial cell; CL=CL_0000066.
Sequence variations
  • Mutation; HGNC; HGNC:4379; GNA11; Simple; p.Gln209Leu (c.626A>T); ClinVar=VCV000376002; Zygosity=Heterozygous (PubMed=24994677; DepMap=ACH-002010).
  • Mutation; HGNC; HGNC:11100; SMARCA4; Simple; p.Thr910Met (c.2729C>T); ClinVar=VCV000438790; Zygosity=Heterozygous (DepMap=ACH-002010).
Disease Uveal melanoma (NCIt: C7712)
Uveal melanoma (ORDO: Orphanet_39044)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E8SW (MP41/GFP)CVCL_E8SX (MP41/Luciferase)CVCL_E8SY (MP41/Luciferase-2A-GFP)
CVCL_E8SZ (MP41/RFP)
Sex of cell Female
Age at sampling 49Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3297; PubMed=24994677

Markers:
AmelogeninX
CSF1PO9,10
D5S81810,13
D7S8208.3,9,9.3,10,10.1,11 (ATCC=CRL-3297)
9,10 (PubMed=24994677)
D13S31711,14
D16S53913
D21S1130.2,31.2
TH016,7
TPOX8,11
vWA15,18

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Publications

PubMed=24994677; DOI=10.1016/j.molonc.2014.06.004; PMCID=PMC5528590
Nabil Amirouchene-Angelozzi, Fariba Nemati, David Gentien, Andre Nicolas, Amaury Dumont, Guillaume Carita, Jacques Camonis, Laurence Desjardins, Nathalie Cassoux, Sophie Piperno-Neumann, Pascale Mariani ...Show all 14 authors... , Xavier Sastre-Garau, Didier Decaudin, Sergio Roman-Roman; Show fewer authors
Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target.
Mol. Oncol. 8:1508-1520(2014)

PubMed=39042403; DOI=10.1167/iovs.65.8.37; PMCID=PMC11268447
Maria Chiara Gelmi, Arnoud H. de Ru, Peter A. van Veelen, Rayman T.N. Tjokrodirijo, Marc-Henri Stern, Alexandre Houy, Robert M. Verdijk, T.H. Khanh Vu, Bruce R. Ksander, Jolanda Vaarwater, Emine Kilic ...Show all 13 authors... , Erwin Brosens, Martine Johanna Jager; Show fewer authors
Protein and mRNA expression in uveal melanoma cell lines are related to GNA and BAP1 mutation status.
Invest. Ophthalmol. Vis. Sci. 65:37-37(2024)

Cross-references
Cell line collections (Providers) ATCC; CRL-3297
Cell line databases/resources cancercelllines; CVCL_4D12
DepMap; ACH-002010
Chemistry resources ChEMBL-Cells; CHEMBL4879544
Encyclopedic resources Wikidata; Q54906429
Proteomic databases PRIDE; PXD051055
Entry history
Entry creation22-Sep-2015
Last entry update14-Aug-2025
Version number14