ID   MP41
AC   CVCL_4D12
DR   ATCC; CRL-3297
DR   cancercelllines; CVCL_4D12
DR   ChEMBL-Cells; CHEMBL4879544
DR   DepMap; ACH-002010
DR   PRIDE; PXD051055
DR   Wikidata; Q54906429
RX   PubMed=24994677;
RX   PubMed=39042403;
CC   Characteristics: Established from a patient-derived xenograft (PubMed=24994677).
CC   Doubling time: 41 hours (PubMed=24994677).
CC   Sequence variation: Mutation; HGNC; HGNC:4379; GNA11; Simple; p.Gln209Leu (c.626A>T); ClinVar=VCV000376002; Zygosity=Heterozygous (PubMed=24994677; DepMap=ACH-002010).
CC   Sequence variation: Mutation; HGNC; HGNC:11100; SMARCA4; Simple; p.Thr910Met (c.2729C>T); ClinVar=VCV000438790; Zygosity=Heterozygous (DepMap=ACH-002010).
CC   Omics: Proteomics.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: In situ; Eye, uvea; UBERON=UBERON_0001768.
CC   Cell type: Epithelial cell; CL=CL_0000066.
ST   Source(s): ATCC=CRL-3297; PubMed=24994677
ST   Amelogenin: X
ST   CSF1PO: 9,10
ST   D13S317: 11,14
ST   D16S539: 13
ST   D21S11: 30.2,31.2
ST   D5S818: 10,13
ST   D7S820: 8.3,9,9.3,10,10.1,11 (ATCC=CRL-3297)
ST   D7S820: 9,10 (PubMed=24994677)
ST   TH01: 6,7
ST   TPOX: 8,11
ST   vWA: 15,18
DI   NCIt; C7712; Uveal melanoma
DI   ORDO; Orphanet_39044; Uveal melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   49Y
CA   Cancer cell line
DT   Created: 22-09-15; Last updated: 14-08-25; Version: 14
CH   CVCL_E8SW ! MP41/GFP
CH   CVCL_E8SX ! MP41/Luciferase
CH   CVCL_E8SY ! MP41/Luciferase-2A-GFP
CH   CVCL_E8SZ ! MP41/RFP
//
RX   PubMed=24994677; DOI=10.1016/j.molonc.2014.06.004; PMCID=PMC5528590;
RA   Amirouchene-Angelozzi, Nabil
RA   Nemati, Fariba
RA   Gentien, David
RA   Nicolas, Andre
RA   Dumont, Amaury
RA   Carita, Guillaume
RA   Camonis, Jacques
RA   Desjardins, Laurence
RA   Cassoux, Nathalie
RA   Piperno-Neumann, Sophie
RA   Mariani, Pascale
RA   Sastre-Garau, Xavier
RA   Decaudin, Didier
RA   Roman-Roman, Sergio
RT   "Establishment of novel cell lines recapitulating the genetic
RT   landscape of uveal melanoma and preclinical validation of mTOR as a
RT   therapeutic target.";
RL   Mol. Oncol. 8:1508-1520(2014).
//
RX   PubMed=39042403; DOI=10.1167/iovs.65.8.37; PMCID=PMC11268447;
RA   Gelmi, Maria Chiara
RA   de Ru, Arnoud H.
RA   van Veelen, Peter A.
RA   Tjokrodirijo, Rayman T.N.
RA   Stern, Marc-Henri
RA   Houy, Alexandre
RA   Verdijk, Robert M.
RA   Vu, T.H. Khanh
RA   Ksander, Bruce R.
RA   Vaarwater, Jolanda
RA   Kilic, Emine
RA   Brosens, Erwin
RA   Jager, Martine Johanna
RT   "Protein and mRNA expression in uveal melanoma cell lines are related
RT   to GNA and BAP1 mutation status.";
RL   Invest. Ophthalmol. Vis. Sci. 65:37-37(2024).
//