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Cellosaurus GIST-T1 (CVCL_4976)

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Cell line name GIST-T1
Synonyms GIST-T-1; GISTT1; T1
Accession CVCL_4976
Resource Identification Initiative To cite this cell line use: GIST-T1 (RRID:CVCL_4976)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Doubling time: 48 hours (PubMed=12004007).
Omics: Genomics; ChIP-seq; H3K27ac.
Omics: Genomics; Chromatin accessibility; ATAC-seq.
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; PTM; Tyrosine phosphorylation.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Cell type: Interstitial cell of Cajal; CL=CL_0002088.
Sequence variations
  • Mutation; HGNC; HGNC:6342; KIT; Simple; p.Val560_Tyr578del (c.1679_1735del); Zygosity=Heterozygous (PubMed=12004007; PubMed=16077968).
Disease Gastrointestinal stromal tumor (NCIt: C3868)
Gastrointestinal stromal tumor (ORDO: Orphanet_44890)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_QW91 (GIST-T1-117)CVCL_QW82 (GIST-T1-R2)CVCL_QW86 (GIST-T1-R8)
CVCL_QW90 (GIST-T1-R9)CVCL_QW89 (GIST-T1-RA2)CVCL_A9M9 (GIST-T1/670)
CVCL_A9N0 (GIST-T1/816)CVCL_S983 (GIST-T1/829)CVCL_C3M2 (GIST-T1/IM-R)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
Web pages Provider; Cosmo Bio; PMC-GIST01C; https://www.cosmobiousa.com/pages/cell-cell-culture-products/gist-t1-cells
Publications

PubMed=12004007; DOI=10.1038/labinvest.3780461
Takahiro Taguchi, Hiroshi Sonobe, Shin-ichi Toyonaga, Ichiro Yamasaki, Taro Shuin, Atsushi Takano, Keijiro Araki, Kunihiro Akimaru, Kazunari Yuri;
Conventional and molecular cytogenetic characterization of a new human cell line, GIST-T1, established from gastrointestinal stromal tumor.
Lab. Invest. 82:663-665(2002)

PubMed=16077968; DOI=10.3892/or.14.3.645
Kazuhiro Noma, Yoshio Naomoto, Mehmet Gunduz, Junji Matsuoka, Tomoki Yamatsuji, Yasuhiro Shirakawa, Tetsuji Nobuhisa, Takaomi Okawa, Munenori Takaoka, Yasuko Tomono, Ohmori Hiroyuki ...Show all 13 authors... , Esra Gunduz, Noriaki Tanaka; Show fewer authors
Effects of imatinib vary with the types of KIT-mutation in gastrointestinal stromal tumor cell lines.
Oncol. Rep. 14:645-650(2005)

PubMed=19706776; DOI=10.1158/0008-5472.CAN-08-4004; PMCID=PMC2905726
Thomas Muhlenberg, Yi-Xiang Zhang, Andrew J. Wagner, Florian Grabellus, James E. Bradner, Georg Taeger, Hauke Lang, Takahiro Taguchi, Martin Schuler, Jonathan A. Fletcher, Sebastian Bauer;
Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors.
Cancer Res. 69:6941-6950(2009)

PubMed=22665524; DOI=10.1158/1535-7163.MCT-12-0223; PMCID=PMC3992122
Michael Charles Heinrich, Adrian Marino-Enriquez, Ajia Presnell, Rachel S. Donsky, Diana J. Griffith, Arin McKinley, Janice Patterson, Takahiro Taguchi, Cher-Wei Liang, Jonathan A. Fletcher;
Sorafenib inhibits many kinase mutations associated with drug-resistant gastrointestinal stromal tumors.
Mol. Cancer Ther. 11:1770-1780(2012)

PubMed=23716303; DOI=10.1002/ijc.28282
Tsuyoshi Takahashi, Satoshi Serada, Maiko Ako, Minoru Fujimoto, Yasuaki Miyazaki, Rie Nakatsuka, Takayuki Ikezoe, Akihito Yokoyama, Takahiro Taguchi, Kazuki Shimada, Yukinori Kurokawa ...Show all 19 authors... , Makoto Yamasaki, Hiroshi Miyata, Kiyokazu Nakajima, Shuji Takiguchi, Masaki Mori, Yuichiro Doki, Tetsuji Naka, Toshirou Nishida; Show fewer authors
New findings of kinase switching in gastrointestinal stromal tumor under imatinib using phosphoproteomic analysis.
Int. J. Cancer 133:2737-2743(2013)

PubMed=25239608; DOI=10.1158/1078-0432.CCR-14-1397; PMCID=PMC4233175
Andrew P. Garner, Joseph M. Gozgit, Rana Anjum, Sadanand Vodala, Alexa B. Schrock, Tian-Jun Zhou, Cesar Serrano, Grant Eilers, Mei-Jun Zhu, Julia Ketzer, Scott Wardwell ...Show all 20 authors... , Yan Ning, Youngchul Song, Anna Kohlmann, Frank Wang, Tim Clackson, Michael Charles Heinrich, Jonathan A. Fletcher, Sebastian Bauer, Victor M. Rivera; Show fewer authors
Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients.
Clin. Cancer Res. 20:5745-5755(2014)

PubMed=27997714; DOI=10.1002/gcc.22438; PMCID=PMC5324566
Tsuyoshi Takahashi, Asmaa Elzawahry, Sachiyo Mimaki, Eisaku Furukawa, Rie Nakatsuka, Hiromi Nakamura, Takahiko Nishigaki, Satoshi Serada, Tetsuji Naka, Seiichi Hirota, Tatsuhiro Shibata ...Show all 14 authors... , Katsuya Tsuchihara, Toshirou Nishida, Mamoru Kato; Show fewer authors
Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors.
Genes Chromosomes Cancer 56:303-313(2017)

PubMed=29866822; DOI=10.1073/pnas.1802079115; PMCID=PMC6016782
Matthew L. Hemming, Matthew A. Lawlor, Rhamy Zeid, Tom Lesluyes, Jonathan A. Fletcher, Chandrajit P. Raut, Ewa T. Sicinska, Frederic Chibon, Scott Allen Armstrong, George Daniel Demetri, James E. Bradner;
Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome.
Proc. Natl. Acad. Sci. U.S.A. 115:E5746-E5755(2018)

PubMed=32736695; DOI=10.1016/j.bbrc.2020.05.174
Woo-Cheol Cho, Young-Kyoung Shin, Young-Soon Na, Min-Hee Ryu, Ja-Lok Ku, Yoon-Koo Kang;
The role of novel fusion genes in human GIST cell lines derived from imatinib-resistant GIST patients: a therapeutic potential of fusion gene.
Biochem. Biophys. Res. Commun. 529:699-706(2020)

PubMed=34738628; DOI=10.3892/or.2021.8218; PMCID=PMC8600406
Takafumi Shima, Kohei Taniguchi, Yoshihisa Tokumaru, Yosuke Inomata, Jun Arima, Sang-Woong Lee, Kazuaki Takabe, Kazuhiro Yoshida, Kazuhisa Uchiyama;
Glucose transporter-1 inhibition overcomes imatinib resistance in gastrointestinal stromal tumor cells.
Oncol. Rep. 47:7.1-7.13(2022)

Cross-references
Cell line databases/resources DepMap; ACH-002332
Chemistry resources ChEMBL-Cells; CHEMBL4482986
ChEMBL-Targets; CHEMBL4483238
PubChem_Cell_line; CVCL_4976
Encyclopedic resources Wikidata; Q54835846
Gene expression databases GEO; GSM1701539
GEO; GSM2527248
GEO; GSM2527250
GEO; GSM2527251
GEO; GSM2527316
GEO; GSM2527317
GEO; GSM2527318
GEO; GSM2527319
GEO; GSM3070588
Polymorphism and mutation databases Cosmic; 1029465
Cosmic; 1873953
Cosmic; 2607430
Cosmic; 2805388
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number19