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Cellosaurus GIST-T1-R8 (CVCL_QW86)

[Text version]
Cell line name GIST-T1-R8
Synonyms GIST-R8; R8
Accession CVCL_QW86
Resource Identification Initiative To cite this cell line use: GIST-T1-R8 (RRID:CVCL_QW86)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI_45783; Imatinib (Gleevec; STI571).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Cell type: Interstitial cell of Cajal; CL=CL_0002088.
Sequence variations
  • Mutation; HGNC; HGNC:6342; KIT; Simple; p.Val560_Tyr578del (c.1679_1735del); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6342; KIT; Simple; p.Asp820Tyr (c.2458G>T); ClinVar=VCV000375928; Zygosity=Heterozygous (PubMed=27997714).
Disease Gastrointestinal stromal tumor (NCIt: C3868)
Gastrointestinal stromal tumor (ORDO: Orphanet_44890)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4976 (GIST-T1)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
Publications

PubMed=23716303; DOI=10.1002/ijc.28282
Tsuyoshi Takahashi, Satoshi Serada, Maiko Ako, Minoru Fujimoto, Yasuaki Miyazaki, Rie Nakatsuka, Takayuki Ikezoe, Akihito Yokoyama, Takahiro Taguchi, Kazuki Shimada, Yukinori Kurokawa ...Show all 19 authors... , Makoto Yamasaki, Hiroshi Miyata, Kiyokazu Nakajima, Shuji Takiguchi, Masaki Mori, Yuichiro Doki, Tetsuji Naka, Toshirou Nishida; Show fewer authors
New findings of kinase switching in gastrointestinal stromal tumor under imatinib using phosphoproteomic analysis.
Int. J. Cancer 133:2737-2743(2013)

PubMed=27997714; DOI=10.1002/gcc.22438; PMCID=PMC5324566
Tsuyoshi Takahashi, Asmaa Elzawahry, Sachiyo Mimaki, Eisaku Furukawa, Rie Nakatsuka, Hiromi Nakamura, Takahiko Nishigaki, Satoshi Serada, Tetsuji Naka, Seiichi Hirota, Tatsuhiro Shibata ...Show all 14 authors... , Katsuya Tsuchihara, Toshirou Nishida, Mamoru Kato; Show fewer authors
Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors.
Genes Chromosomes Cancer 56:303-313(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_QW86
Encyclopedic resources Wikidata; Q54835849
Gene expression databases GEO; GSM1701541
Polymorphism and mutation databases Cosmic; 2607431
Entry history
Entry creation15-Nov-2017
Last entry update10-Apr-2025
Version number12