Cellosaurus cell line GIST-T1-RA2 (CVCL

Cellosaurus GIST-T1-RA2 (CVCL_QW89)

Cross-references
Cell line name	GIST-T1-RA2
Synonyms	GIST-RA2; RA2
Accession	CVCL_QW89
Resource Identification Initiative	To cite this cell line use: GIST-T1-RA2 (RRID:CVCL_QW89)
Comments	Population: Japanese. Selected for resistance to: ChEBI; CHEBI_45783; Imatinib (Gleevec; STI571). Omics: Genomics; Whole exome sequencing. Omics: Transcriptomics; Microarray. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. Cell type: Interstitial cell of Cajal; CL=CL_0002088.
Sequence variations	Mutation; HGNC; HGNC:6342; KIT; Simple; p.Val560_Tyr578del (c.1679_1735del); Zygosity=Heterozygous (from parent cell line).
Disease	Gastrointestinal stromal tumor (NCIt: C3868) Gastrointestinal stromal tumor (ORDO: Orphanet_44890)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_4976 (GIST-T1)
Sex of cell	Female
Age at sampling	47Y
Category	Cancer cell line
Publications	PubMed=27997714; DOI=10.1002/gcc.22438; PMCID=PMC5324566 Tsuyoshi Takahashi, Asmaa Elzawahry, Sachiyo Mimaki, Eisaku Furukawa, Rie Nakatsuka, Hiromi Nakamura, Takahiko Nishigaki, Satoshi Serada, Tetsuji Naka, Seiichi Hirota, Tatsuhiro Shibata ...Show all 14 authors... , Katsuya Tsuchihara, Toshirou Nishida, Mamoru Kato; Show fewer authors Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors. Genes Chromosomes Cancer 56:303-313(2017)
Encyclopedic resources	Wikidata; Q54835851
Gene expression databases	GEO; GSM1701542
Polymorphism and mutation databases	Cosmic; 2607432
Entry history
Entry creation	15-Nov-2017
Last entry update	10-Apr-2025
Version number	11