| Cell line name |
SKO-007 |
| Synonyms |
SKO007; U-226AR1; U-266 AR1 |
| Accession |
CVCL_4974 |
| Resource Identification Initiative |
To cite this cell line use: SKO-007 (RRID:CVCL_4974) |
| Comments |
Group: Hybridoma fusion partner cell line. Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8033. Population: Caucasian. Characteristics: Produces IgE lambda (from parent cell line). Selected for resistance to: ChEBI; CHEBI_63486; 8-azaguanine. Omics: Variations; SNP array analysis. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: Plasma cell; CL=CL_0000786. |
| Sequence variations |
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Lys601Asn (c.1803A>T); ClinVar=VCV000376285; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Gly141Asp (c.422G>A); ClinVar=VCV001491786; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ala161Thr (c.481G>A); ClinVar=VCV000161518; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:12033; TRAF3; Simple; p.Lys550Leufs*3 (c.1648_1649insT); Zygosity=Homozygous (from parent cell line).
|
| Disease |
Plasma cell myeloma (NCIt: C3242) Multiple myeloma (ORDO: Orphanet_29073) |
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
| Hierarchy |
Parent: CVCL_0566 (U266B1) Children:
|
| Sex of cell |
Male |
| Age at sampling |
53Y |
| Category |
Cancer cell line |
| STR profile |
Source(s): ATCC=CRL-8033-1
Markers:| Amelogenin | X,Y |
| CSF1PO | 12,13 |
| D2S1338 | 20,23 |
| D3S1358 | 17 |
| D5S818 | 11,12 |
| D7S820 | 11,12 |
| D8S1179 | 13 |
| D13S317 | 12 |
| D16S539 | 10 |
| D18S51 | 12,14 |
| D19S433 | 13,15 |
| D21S11 | 28,29 |
| FGA | 18 |
| Penta D | 10,13 |
| Penta E | 10,12 |
| TH01 | 5,7 |
| TPOX | 8 |
| vWA | 17 |
Run an STR similarity search on this cell line |
| Publications | PubMed=6159646; DOI=10.1073/pnas.77.9.5429; PMCID=PMC350072 Lennart Olsson, Henry Seymour Kaplan; Human-human hybridomas producing monoclonal antibodies of predefined antigenic specificity. Proc. Natl. Acad. Sci. U.S.A. 77:5429-5431(1980) PubMed=6864164; DOI=10.1084/jem.158.1.53; PMCID=PMC2187084 Alan N. Houghton, Hannah Brooks, Richard J. Cote, Michael C. Taormina, Herbert Friedrich Oettgen, Lloyd John Old; Detection of cell surface and intracellular antigens by human monoclonal antibodies. Hybrid cell lines derived from lymphocytes of patients with malignant melanoma. J. Exp. Med. 158:53-65(1983) PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662 S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res. 70:2158-2164(2010) |
| Cross-references |
| Cell line collections (Providers) |
ATCC; CRL-8033-1
|
| Cell line databases/resources |
CLO; CLO_0009061
cancercelllines; CVCL_4974
IGRhCellID; SKO007
|
| Encyclopedic resources |
Wikidata; Q54954759
|
| Experimental variables resources |
EFO; EFO_0002339
|
| Gene expression databases |
ArrayExpress; E-MTAB-38
|
| Polymorphism and mutation databases |
Cosmic; 2159572
Progenetix; CVCL_4974
|
| Entry history |
| Entry creation | 04-Apr-2012 |
| Last entry update | 14-Aug-2025 |
| Version number | 29 |
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