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Cellosaurus SKO-007 (CVCL_4974)

[Text version]
Cell line name SKO-007
Synonyms SKO007; U-226AR1; U-266 AR1
Accession CVCL_4974
Resource Identification Initiative To cite this cell line use: SKO-007 (RRID:CVCL_4974)
Comments Group: Hybridoma fusion partner cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8033.
Population: Caucasian.
Characteristics: Produces IgE lambda (from parent cell line).
Selected for resistance to: ChEBI; CHEBI:63486; 8-azaguanine.
Omics: SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Lys601Asn (c.1803A>T); ClinVar=VCV000376285; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Gly141Asp (c.422G>A); ClinVar=VCV001491786; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ala161Thr (c.481G>A); ClinVar=VCV000161518; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 12033; TRAF3; Simple; p.Lys550Leufs*3 (c.1648_1649insT); Zygosity=Homozygous (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0566 (U266B1)
Children:
CVCL_4975 (SKO-007 clone J3)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX,Y
CSF1PO12,13
D5S81811,12
D7S82011,12
D13S31712
D16S53910
TH015,7
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=6159646; DOI=10.1073/pnas.77.9.5429
Olsson L., Kaplan H.S.
Human-human hybridomas producing monoclonal antibodies of predefined antigenic specificity.
Proc. Natl. Acad. Sci. U.S.A. 77:5429-5431(1980)

PubMed=6864164; DOI=10.1084/jem.158.1.53
Houghton A.N., Brooks H., Cote R.J., Taormina M.C., Oettgen H.F., Old L.J.
Detection of cell surface and intracellular antigens by human monoclonal antibodies. Hybrid cell lines derived from lymphocytes of patients with malignant melanoma.
J. Exp. Med. 158:53-65(1983)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections (Providers) ATCC; CRL-8033-1
Cell line databases/resources CLO; CLO_0009061
cancercelllines; CVCL_4974
IGRhCellID; SKO007
Encyclopedic resources Wikidata; Q54954759
Experimental variables resources EFO; EFO_0002339
Gene expression databases ArrayExpress; E-MTAB-38
Polymorphism and mutation databases Cosmic; 2159572
Progenetix; CVCL_4974
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number24