ID   SKO-007
AC   CVCL_4974
SY   SKO007; U-226AR1; U-266 AR1
DR   CLO; CLO_0009061
DR   EFO; EFO_0002339
DR   ArrayExpress; E-MTAB-38
DR   ATCC; CRL-8033-1
DR   cancercelllines; CVCL_4974
DR   Cosmic; 2159572
DR   IGRhCellID; SKO007
DR   Progenetix; CVCL_4974
DR   Wikidata; Q54954759
RX   PubMed=6159646;
RX   PubMed=6864164;
RX   PubMed=20215515;
CC   Group: Hybridoma fusion partner cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8033.
CC   Population: Caucasian.
CC   Characteristics: Produces IgE lambda (from parent cell line).
CC   Selected for resistance to: ChEBI; CHEBI:63486; 8-azaguanine.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Lys601Asn (c.1803A>T); ClinVar=VCV000376285; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7329; MSH6; Simple; p.Gly141Asp (c.422G>A); ClinVar=VCV001491786; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ala161Thr (c.481G>A); ClinVar=VCV000161518; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 12033; TRAF3; Simple; p.Lys550Leufs*3 (c.1648_1649insT); Zygosity=Homozygous (from parent cell line).
CC   Omics: SNP array analysis.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): ATCC
ST   Amelogenin: X,Y
ST   CSF1PO: 12,13
ST   D13S317: 12
ST   D16S539: 10
ST   D5S818: 11,12
ST   D7S820: 11,12
ST   TH01: 5,7
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0566 ! U266B1
SX   Male
AG   53Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 24
RX   PubMed=6159646; DOI=10.1073/pnas.77.9.5429;
RA   Olsson L., Kaplan H.S.;
RT   "Human-human hybridomas producing monoclonal antibodies of predefined
RT   antigenic specificity.";
RL   Proc. Natl. Acad. Sci. U.S.A. 77:5429-5431(1980).
RX   PubMed=6864164; DOI=10.1084/jem.158.1.53;
RA   Houghton A.N., Brooks H., Cote R.J., Taormina M.C., Oettgen H.F.,
RA   Old L.J.;
RT   "Detection of cell surface and intracellular antigens by human
RT   monoclonal antibodies. Hybrid cell lines derived from lymphocytes of
RT   patients with malignant melanoma.";
RL   J. Exp. Med. 158:53-65(1983).
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).