ID   SKO-007
AC   CVCL_4974
SY   SKO007; U-226AR1; U-266 AR1
DR   CLO; CLO_0009061
DR   EFO; EFO_0002339
DR   ArrayExpress; E-MTAB-38
DR   ATCC; CRL-8033-1
DR   cancercelllines; CVCL_4974
DR   Cosmic; 2159572
DR   IGRhCellID; SKO007
DR   Progenetix; CVCL_4974
DR   Wikidata; Q54954759
RX   PubMed=6159646;
RX   PubMed=6864164;
RX   PubMed=20215515;
CC   Group: Hybridoma fusion partner cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8033.
CC   Population: Caucasian.
CC   Characteristics: Produces IgE lambda (from parent cell line).
CC   Selected for resistance to: ChEBI; CHEBI_63486; 8-azaguanine.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Lys601Asn (c.1803A>T); ClinVar=VCV000376285; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Gly141Asp (c.422G>A); ClinVar=VCV001491786; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ala161Thr (c.481G>A); ClinVar=VCV000161518; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:12033; TRAF3; Simple; p.Lys550Leufs*3 (c.1648_1649insT); Zygosity=Homozygous (from parent cell line).
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: Plasma cell; CL=CL_0000786.
ST   Source(s): ATCC=CRL-8033-1
ST   Amelogenin: X,Y
ST   CSF1PO: 12,13
ST   D13S317: 12
ST   D16S539: 10
ST   D18S51: 12,14
ST   D19S433: 13,15
ST   D21S11: 28,29
ST   D2S1338: 20,23
ST   D3S1358: 17
ST   D5S818: 11,12
ST   D7S820: 11,12
ST   D8S1179: 13
ST   FGA: 18
ST   Penta D: 10,13
ST   Penta E: 10,12
ST   TH01: 5,7
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0566 ! U266B1
SX   Male
AG   53Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 29
CH   CVCL_4975 ! SKO-007 clone J3
//
RX   PubMed=6864164; DOI=10.1084/jem.158.1.53; PMCID=PMC2187084;
RA   Houghton, Alan N.
RA   Brooks, Hannah
RA   Cote, Richard J.
RA   Taormina, Michael C.
RA   Oettgen, Herbert Friedrich
RA   Old, Lloyd John
RT   "Detection of cell surface and intracellular antigens by human
RT   monoclonal antibodies. Hybrid cell lines derived from lymphocytes of
RT   patients with malignant melanoma.";
RL   J. Exp. Med. 158:53-65(1983).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=6159646; DOI=10.1073/pnas.77.9.5429; PMCID=PMC350072;
RA   Olsson, Lennart
RA   Kaplan, Henry Seymour
RT   "Human-human hybridomas producing monoclonal antibodies of predefined
RT   antigenic specificity.";
RL   Proc. Natl. Acad. Sci. U.S.A. 77:5429-5431(1980).
//