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Cellosaurus pRNS-1-1 (CVCL_4890)

[Text version]
Cell line name pRNS-1-1
Accession CVCL_4890
Resource Identification Initiative To cite this cell line use: pRNS-1-1 (RRID:CVCL_4890)
Comments Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pRNS-1).
Derived from site: In situ; Prostate, epithelium; UBERON=UBERON_0000428.
Cell type: Epithelial cell of prostate; CL=CL_0002231.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4891 (pRNS-1-1/ras)CVCL_4899 (SCID 5045-4)
Sex of cell Male
Age at sampling 53Y
Category Transformed cell line
Publications

PubMed=21566988; DOI=10.3892/ijo.4.4.821
Myeong-Seon Lee, Evelina Garkovenko, Jae Soon Yun, Philip C. Weijerman, Donna M. Peehl, Lian-Sheng Chen, Johng Sik Rhim;
Characterization of adult human prostatic epithelial-cells immortalized by polybrene-induced DNA transfection with a plasmid containing an origin-defective SV40-genome.
Int. J. Oncol. 4:821-830(1994)

PubMed=8977636; DOI=10.1002/(SICI)1097-0045(199612)29:6<386::AID-PROS7>3.0.CO;2-6
Mukta M. Webber, Diana Bello, Salmaan T.A. Quader;
Immortalized and tumorigenic adult human prostatic epithelial cell lines: characteristics and applications. Part I. Cell markers and immortalized nontumorigenic cell lines.
Prostate 29:386-394(1996)

PubMed=21544329; DOI=10.3892/ijo.8.1.41
Coleman Gross, Roman J. Skowronski, Stephen Rex Plymate, Johng Sik Rhim, Donna M. Peehl, David Feldman;
Simian virus 40-, but not human papillomavirus-, transformation of prostatic epithelial cells results in loss of growth-inhibition by 1,25-dihydroxyvitamin D-3.
Int. J. Oncol. 8:41-47(1996)

PubMed=9276642; DOI=10.1093/carcin/18.8.1643
Donna M. Peehl, Stephen T. Wong, Robert G. Sellers, Sun-Ji Jin, Johng Sik Rhim;
Loss of response to epidermal growth factor and retinoic acid accompanies the transformation of human prostatic epithelial cells to tumorigenicity with v-Ki-ras.
Carcinogenesis 18:1643-1650(1997)

Cross-references
Encyclopedic resources Wikidata; Q54948366
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number14