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Cellosaurus E006AA (CVCL_4834)

[Text version]
Cell line name E006AA
Synonyms E006AA-Par; E006AA-Pr
Accession CVCL_4834
Resource Identification Initiative To cite this cell line use: E006AA (RRID:CVCL_4834)
Comments Problematic cell line: Contaminated. Shown to be a 786-O derivative (PubMed=31416301). Originally thought to originate from a 50 year old patient with prostate carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00585.
Population: Caucasian.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Mutation; HGNC; 9588; PTEN; Simple; p.Gln149Ter (c.445C>T); ClinVar=VCV000404164; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.560-2A>G; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro278Ala (c.832C>G); ClinVar=VCV000376645; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 12687; VHL; Simple; p.Gly104Alafs*55 (c.311delG); Zygosity=Homozygous (from parent cell line).
Disease Renal cell carcinoma (NCIt: C9385)
Renal cell carcinoma (ORDO: Orphanet_217071)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1051 (786-O)
Children:
CVCL_YI81 (E006AA ZIC2-/- E5)CVCL_YI82 (E006AA ZIC2-/- G12)CVCL_X480 (E006AA-hT)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): Millipore=SCC102

Markers:
AmelogeninX
CSF1PO10
D3S135816
D5S8189
D7S82011
D8S117913
D13S3178
D16S53912
D18S5113,14
D21S1129,30
FGA24
Penta D9,12
Penta E7,16
TH016,9.3
TPOX8,11
vWA15,17

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=15162380; DOI=10.1002/pros.20053
Koochekpour S., Maresh G.A., Katner A., Parker-Johnson K., Lee T.-J., Hebert F.E., Kao Y.S., Skinner J., Rayford W.
Establishment and characterization of a primary androgen-responsive African-American prostate cancer cell line, E006AA.
Prostate 60:141-152(2004)

PubMed=25076860; DOI=10.7150/ijbs.9406
Koochekpour S., Willard S.S., Shourideh M., Ali S., Liu C.-H., Azabdaftari G., Saleem M., Attwood K.
Establishment and characterization of a highly tumorigenic African American prostate cancer cell line, E006AA-hT.
Int. J. Biol. Sci. 10:834-845(2014)

CLPUB00549
Moore J.C.
Establishment Of CRISPR/Cas-9 aided knockout of the ZIC2 gene in the African-American prostate cancer cell line E006AA-PR.
Thesis MSc (2019), Clark Atlanta University, United States

PubMed=31416301; DOI=10.1002/pros.23800
Koochekpour S., Maresh G.A., Katner A., Parker-Johnson K., Lee T.-J., Hebert F.E., Kao Y.S., Skinner J., Rayford W.
Correction: Establishment and characterization of a primary androgen-responsive African-American prostate cancer cell line, E006AA. Prostate 2004;60(2):145-152.
Prostate 79:815-815(2019)

Cross-references
Cell line collections (Providers) Millipore; SCC102 - Discontinued
Cell line databases/resources cancercelllines; CVCL_4834
Encyclopedic resources Wikidata; Q38514722
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number21