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Cellosaurus E006AA-hT (CVCL_X480)

[Text version]
Cell line name E006AA-hT
Synonyms E006AA-highly Tumorigenic
Accession CVCL_X480
Resource Identification Initiative To cite this cell line use: E006AA-hT (RRID:CVCL_X480)
Comments Problematic cell line: Contaminated. Parent cell line (E006AA) has been shown to be a 786-O derivative.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00586.
Population: Caucasian.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Mutation; HGNC; 9588; PTEN; Simple; p.Gln149Ter (c.445C>T); ClinVar=VCV000404164; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.560-2A>G; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro278Ala (c.832C>G); ClinVar=VCV000376645; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 12687; VHL; Simple; p.Gly104Alafs*55 (c.311delG); Zygosity=Homozygous (from parent cell line).
Disease Renal cell carcinoma (NCIt: C9385)
Renal cell carcinoma (ORDO: Orphanet_217071)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4834 (E006AA)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3277


Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx

PubMed=25076860; DOI=10.7150/ijbs.9406
Koochekpour S., Willard S.S., Shourideh M., Ali S., Liu C.-H., Azabdaftari G., Saleem M., Attwood K.
Establishment and characterization of a highly tumorigenic African American prostate cancer cell line, E006AA-hT.
Int. J. Biol. Sci. 10:834-845(2014)

PubMed=30787054; DOI=10.1158/1055-9965.EPI-18-1132
Hooker S.E. Jr., Woods-Burnham L., Bathina M., Lloyd S., Gorjala P., Mitra R., Nonn L., Kimbro K.S., Kittles R.A.
Genetic ancestry analysis reveals misclassification of commonly used cancer cell lines.
Cancer Epidemiol. Biomarkers Prev. 28:1003-1009(2019)

PubMed=31416301; DOI=10.1002/pros.23800
Koochekpour S., Maresh G.A., Katner A., Parker-Johnson K., Lee T.-J., Hebert F.E., Kao Y.S., Skinner J., Rayford W.
Correction: Establishment and characterization of a primary androgen-responsive African-American prostate cancer cell line, E006AA. Prostate 2004;60(2):145-152.
Prostate 79:815-815(2019)

Cell line collections (Providers) ATCC; CRL-3277 - Discontinued
Cell line databases/resources cancercelllines; CVCL_X480
Encyclopedic resources Wikidata; Q38514377
Entry history
Entry creation05-Sep-2014
Last entry update02-May-2024
Version number16