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Cellosaurus MDA-PCa-2a (CVCL_4747)

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Cell line name MDA-PCa-2a
Synonyms MDA PCa 2a; MDAPC2A; MDA2A; M.D. Anderson-Prostate Cancer-2a
Accession CVCL_4747
Resource Identification Initiative To cite this cell line use: MDA-PCa-2a (RRID:CVCL_4747)
Comments Population: African American.
Doubling time: 82 hours (Note=In BRFF-HPC1 + 20% FBS), 87-93 hours (Note=In F12K(+) + 20% FBS) (PubMed=9815652).
Omics: Transcriptomics; Microarray.
Omics: Variations; Array-based CGH.
Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_4748 ! MDA-PCa-2b
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2421; PubMed=14518029

Markers:
AmelogeninX,Y
CSF1PO10,12
D3S135814,17,18
D5S81812,13
D7S8208,10
D8S117914,15
D13S31711,12
D16S53910,11
D18S5116,17
D21S1131,32,33.2
FGA19,22
TH018,9
TPOX8,11
vWA15,16

Run an STR similarity search on this cell line
Publications

PubMed=9815652
Nora M. Navone, Matilde Olive, Mustafa Ozen, Rodney Davis, Patricia Troncoso, Shi-Ming Tu, Dennis A. Johnston, Allan Pollack, Sen Pathak, Andrew C. von Eschenbach, Christopher J. Logothetis;
Establishment of two human prostate cancer cell lines derived from a single bone metastasis.
Clin. Cancer Res. 3:2493-2500(1997)

PubMed=12725112; DOI=10.1385/1-59259-372-0:21
Pamela J. Russell, Elizabeth A. Kingsley;
Human prostate cancer cell lines.
Methods Mol. Med. 81:21-39(2003)

PubMed=14518029; DOI=10.1002/pros.10290
Adrie van Bokhoven, Marileila Varella-Garcia, Christopher T. Korch, Widya U. Johannes, E. Erin Smith, Heidi L. Miller, Steven K. Nordeen, Gary J. Miller, M. Scott Lucia;
Molecular characterization of human prostate carcinoma cell lines.
Prostate 57:205-225(2003)

PubMed=14518030; DOI=10.1002/pros.10291
Adrie van Bokhoven, Aimee Caires, Michael Di Maria, Aline Passarini Schulte, M. Scott Lucia, Steven K. Nordeen, Gary J. Miller, Marileila Varella-Garcia;
Spectral karyotype (SKY) analysis of human prostate carcinoma cell lines.
Prostate 57:226-244(2003)

CLPUB00698
Adrie van Bokhoven;
Models for prostate cancer. Molecular characterization and critical appraisal of human prostate carcinoma cell lines.
Thesis PhD (2004); Katholieke Universiteit Nijmegen; Nijmegen; Netherlands

PubMed=15486987; DOI=10.1002/pros.20158
Hong-Juan Zhao, Young Kim, Pei Wang, Jacques Lapointe, Robert Tibshirani, Jonathan R. Pollack, James D. Brooks;
Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines.
Prostate 63:187-197(2005)

Cross-references
Cell line collections (Providers) ATCC; CRL-2421 - Discontinued
Cell line databases/resources cancercelllines; CVCL_4747
Cell_Model_Passport; SIDM01666
Biological sample resources BioSample; SAMN03471839
Encyclopedic resources Wikidata; Q54904652
Gene expression databases GEO; GSM91925
Polymorphism and mutation databases Progenetix; CVCL_4747
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27