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Cellosaurus MDA-PCa-2b (CVCL_4748)

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Cell line name MDA-PCa-2b
Synonyms MDA PCa 2b; MDAPCa-2b; MDAPCa2b; MDAPCA2B; MDAPC2B; MDA2B; M.D. Anderson-Prostate Cancer-2b
Accession CVCL_4748
Resource Identification Initiative To cite this cell line use: MDA-PCa-2b (RRID:CVCL_4748)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: TCGA-110-CL cell line panel.
Population: African American.
Doubling time: 42-53 hours (Note=In BRFF-HPC1 + 20% FBS), 61-73 hours (Note=In F12K(+) + 20% FBS) (PubMed=9815652); 89.15 hours (JWGray panel).
Microsatellite instability: Instable (MSI) (PubMed=23671654; PubMed=31068700).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
Genome ancestry Source: PubMed=30894373

Origin% genome
African90.02
Native American0
East Asian, North2.64
East Asian, South0
South Asian0
European, North0
European, South7.34
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4867 (MDA-PCa-2b-hr)
Originate from same individual CVCL_4747 ! MDA-PCa-2a
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2422; PubMed=14518029

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133822,24
D3S135814,17
D5S81812,13
D7S8208,10
D8S117914,15
D13S31711,12
D16S53910,11
D18S5116,17
D19S43313.2,14.2,16
D21S1133.2
FGA20,21,22 (ATCC=CRL-2422)
20,22 (PubMed=14518029)
Penta D11,13
Penta E8,14
TH018,9
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=9815652
Nora M. Navone, Matilde Olive, Mustafa Ozen, Rodney Davis, Patricia Troncoso, Shi-Ming Tu, Dennis A. Johnston, Allan Pollack, Sen Pathak, Andrew C. von Eschenbach, Christopher J. Logothetis;
Establishment of two human prostate cancer cell lines derived from a single bone metastasis.
Clin. Cancer Res. 3:2493-2500(1997)

PubMed=12725112; DOI=10.1385/1-59259-372-0:21
Pamela J. Russell, Elizabeth A. Kingsley;
Human prostate cancer cell lines.
Methods Mol. Med. 81:21-39(2003)

PubMed=14518029; DOI=10.1002/pros.10290
Adrie van Bokhoven, Marileila Varella-Garcia, Christopher T. Korch, Widya U. Johannes, E. Erin Smith, Heidi L. Miller, Steven K. Nordeen, Gary J. Miller, M. Scott Lucia;
Molecular characterization of human prostate carcinoma cell lines.
Prostate 57:205-225(2003)

PubMed=14518030; DOI=10.1002/pros.10291
Adrie van Bokhoven, Aimee Caires, Michael Di Maria, Aline Passarini Schulte, M. Scott Lucia, Steven K. Nordeen, Gary J. Miller, Marileila Varella-Garcia;
Spectral karyotype (SKY) analysis of human prostate carcinoma cell lines.
Prostate 57:226-244(2003)

CLPUB00698
Adrie van Bokhoven;
Models for prostate cancer. Molecular characterization and critical appraisal of human prostate carcinoma cell lines.
Thesis PhD (2004); Katholieke Universiteit Nijmegen; Nijmegen; Netherlands

PubMed=15486987; DOI=10.1002/pros.20158
Hong-Juan Zhao, Young Kim, Pei Wang, Jacques Lapointe, Robert Tibshirani, Jonathan R. Pollack, James D. Brooks;
Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines.
Prostate 63:187-197(2005)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23671654; DOI=10.1371/journal.pone.0063056; PMCID=PMC3646030
Yu-Heng Lu, T. David Soong, Olivier Elemento;
A novel approach for characterizing microsatellite instability in cancer cells.
PLoS ONE 8:e63056.1-e63056.10(2013)

PubMed=30787054; DOI=10.1158/1055-9965.EPI-18-1132; PMCID=PMC6548687
Stanley Eugene Hooker Jr., Leanne Woods-Burnham, Madhavi Bathina, Stacy Lloyd, Priyatham Gorjala, Ranjana Mitra, Larisa Nonn, K. Sean Kimbro, Rick Antonius Kittles;
Genetic ancestry analysis reveals misclassification of commonly used cancer cell lines.
Cancer Epidemiol. Biomarkers Prev. 28:1003-1009(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2; PMCID=PMC6687785
Katharine Yu, Bin Chen, Dvir Aran, Joe Charalel, Christina Yau, Douglas M. Wolf, Laura J. van 't Veer, Atul Janardhan Butte, Ted Goldstein, Marina Sirota;
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574.1-3574.11(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-2422
Cell line databases/resources CLO; CLO_0007629
cancercelllines; CVCL_4748
Cell_Model_Passport; SIDM01664
DepMap; ACH-000952
Anatomy/cell type resources BTO; BTO_0005050
Biological sample resources BioSample; SAMN03471841
BioSample; SAMN10988222
Chemistry resources PharmacoDB; MDAPCa2b_896_2019
Encyclopedic resources Wikidata; Q54904655
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM91928
GEO; GSM648821
GEO; GSM887302
GEO; GSM888377
Polymorphism and mutation databases Cosmic; 1689712
Cosmic; 2651771
Cosmic; 2669171
IARC_TP53; 30117
LiGeA; CCLE_281
Progenetix; CVCL_4748
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number36