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Cellosaurus PK-1 (CVCL_4717)

[Text version]
Cell line name PK-1
Synonyms PK1
Accession CVCL_4717
Resource Identification Initiative To cite this cell line use: PK-1 (RRID:CVCL_4717)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: NCI RAS program mutant KRAS cell line panel.
Population: Japanese.
Doubling time: 48 hours (PubMed=3547771; PubMed=6205469); 24.1 hours (PubMed=8872523).
Omics: Genomics; Whole exome sequencing.
Omics: Metabolomics.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.26
Native American0
East Asian, North88.21
East Asian, South8.65
South Asian0.93
European, North0.7
European, South1.25
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_5146 (KLM-1)CVCL_0B31 (RPK-1)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=25877200; RCB=RCB1972; TKG=TKG 0239

Markers:
AmelogeninX,Y
CSF1PO12
D3S135815
D5S81811,12
D7S82011
D8S117910,15
D13S3179,10
D16S53912
D18S5113
D21S1131
FGA22,24
Penta D9
Penta E9,20
TH019 (TKG=TKG 0239)
9,10 (PubMed=25877200; RCB=RCB1972)
TPOX9,11
vWA15,19

Run an STR similarity search on this cell line
Publications

PubMed=6205469; DOI=10.1620/tjem.143.33
Masao Kobari, Seiki Matsuno, Toshio Sato, Mikio Kan, Takehiko Tachibana;
Establishment of a human pancreatic cancer cell line and detection of pancreatic cancer associated antigen.
Tohoku J. Exp. Med. 143:33-46(1984)

PubMed=3547771; DOI=10.1620/tjem.150.231
Masao Kobari, Hirotake Hisano, Seiki Matsuno, Toshio Sato, Mikio Kan, Takehiko Tachibana;
Establishment of six human pancreatic cancer cell lines and their sensitivities to anti-tumor drugs.
Tohoku J. Exp. Med. 150:231-248(1986)

PubMed=8872523; DOI=10.1007/BF02787375
Yoshiaru Kimura, Masao Kobari, Tohru Yusa, Makoto Sunamura, M. Kimura, Hiromune Shimamura, Seiki Matsuno;
Establishment of an experimental liver metastasis model by intraportal injection of a newly derived human pancreatic cancer cell line (KLM-1).
Int. J. Pancreatol. 20:43-50(1996)

PubMed=11115575; DOI=10.3892/or.8.1.89
Chun-Lan Sun, Takashi Yamato, Toru Furukawa, Yasuyuki Ohnishi, Hiroshi Kijima, Akira Horii;
Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.
Oncol. Rep. 8:89-92(2001)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22490663; DOI=10.1016/j.bbrc.2012.03.122
Yuriko Saiki, Yuki Yoshino, Hiroko Fujimura, Tatsuya Manabe, Yuki Kudo, Miki Shimada, Nariyasu Mano, Tomohiro Nakano, Yoonha Lee, Shinjiro Shimizu, Shinya Oba ...Show all 23 authors... , Sho Fujiwara, Hideyuki Shimizu, Na Chen, Zhaleh Kashkouli Nezhad, Guo Jin, Shinichi Fukushige, Makoto Sunamura, Masaharu Ishida, Fuyuhiko Motoi, Shinichi Egawa, Michiaki Unno, Akira Horii; Show fewer authors
DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells.
Biochem. Biophys. Res. Commun. 421:98-104(2012)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26216984; DOI=10.1073/pnas.1501605112; PMCID=PMC4538616
Anneleen Daemen, David Peterson, Nisebita Sahu, Ron McCord, Xiang-Nan Du, Bonnie Liu, Katarzyna Kowanetz, Rebecca Hong, John Moffat, Min Gao, Aaron Boudreau ...Show all 22 authors... , Rana Mroue, Laura Corson, Thomas O'Brien, Jing Qing, Deepak Sampath, Mark Merchant, Robert L. Yauch, Gerard Manning, Jeffrey Settleman, Georgia Hatzivassiliou, Marie Evangelista; Show fewer authors
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.
Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) RCB; RCB1972
TKG; TKG 0239
Cell line databases/resources CLO; CLO_0050105
cancercelllines; CVCL_4717
Cell_Model_Passport; SIDM01321
DepMap; ACH-000307
Anatomy/cell type resources BTO; BTO_0004854
Biological sample resources BioSample; SAMN03472897
BioSample; SAMN10988147
CRISP screens repositories BioGRID_ORCS_Cell_line; 486
Chemistry resources PharmacoDB; PK1_1265_2019
Encyclopedic resources Wikidata; Q54947429
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM862564
GEO; GSM862566
GEO; GSM887515
GEO; GSM888597
GEO; GSM1588614
GEO; GSM1588626
Polymorphism and mutation databases Cosmic; 707253
Cosmic; 1066176
Cosmic; 1644297
Cosmic; 2046536
IARC_TP53; 14301
LiGeA; CCLE_500
Progenetix; CVCL_4717
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number32