ID   PK-1
AC   CVCL_4717
SY   PK1
DR   BTO; BTO:0004854
DR   CLO; CLO_0050105
DR   ArrayExpress; E-MTAB-2770
DR   BioGRID_ORCS_Cell_line; 486
DR   BioSample; SAMN03472897
DR   BioSample; SAMN10988147
DR   cancercelllines; CVCL_4717
DR   Cell_Model_Passport; SIDM01321
DR   Cosmic; 707253
DR   Cosmic; 1066176
DR   Cosmic; 1644297
DR   Cosmic; 2046536
DR   DepMap; ACH-000307
DR   GEO; GSM862564
DR   GEO; GSM862566
DR   GEO; GSM887515
DR   GEO; GSM888597
DR   GEO; GSM1588614
DR   GEO; GSM1588626
DR   IARC_TP53; 14301
DR   LiGeA; CCLE_500
DR   PharmacoDB; PK1_1265_2019
DR   Progenetix; CVCL_4717
DR   RCB; RCB1972
DR   TKG; TKG 0239
DR   Wikidata; Q54947429
RX   PubMed=3547771;
RX   PubMed=6205469;
RX   PubMed=8872523;
RX   PubMed=11115575;
RX   PubMed=22460905;
RX   PubMed=22490663;
RX   PubMed=25877200;
RX   PubMed=26216984;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: NCI RAS program mutant KRAS cell line panel.
CC   Population: Japanese.
CC   Doubling time: 48 hours (PubMed=3547771; PubMed=6205469); 24.1 hours (PubMed=8872523).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=11115575; PubMed=22490663; DepMap).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Met237Ile (c.711G>A); ClinVar=VCV000142714; Zygosity=Homozygous (PubMed=11115575; PubMed=22490663; DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: Metabolome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=0.26%; Native American=0%; East Asian, North=88.21%; East Asian, South=8.65%; South Asian=0.93%; European, North=0.7%; European, South=1.25% (PubMed=30894373).
CC   Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
ST   Source(s): PubMed=25877200; RCB; TKG
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 9,10
ST   D16S539: 12
ST   D18S51: 13
ST   D21S11: 31
ST   D3S1358: 15
ST   D5S818: 11,12
ST   D7S820: 11
ST   D8S1179: 10,15
ST   FGA: 22,24
ST   Penta D: 9
ST   Penta E: 9,20
ST   TH01: 9 (TKG)
ST   TH01: 9,10 (PubMed=25877200; RCB)
ST   TPOX: 9,11
ST   vWA: 15,19
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 29
//
RX   PubMed=3547771; DOI=10.1620/tjem.150.231;
RA   Kobari M., Hisano H., Matsuno S., Sato T., Kan M., Tachibana T.;
RT   "Establishment of six human pancreatic cancer cell lines and their
RT   sensitivities to anti-tumor drugs.";
RL   Tohoku J. Exp. Med. 150:231-248(1986).
//
RX   PubMed=6205469; DOI=10.1620/tjem.143.33;
RA   Kobari M., Matsuno S., Sato T., Kan M., Tachibana T.;
RT   "Establishment of a human pancreatic cancer cell line and detection of
RT   pancreatic cancer associated antigen.";
RL   Tohoku J. Exp. Med. 143:33-46(1984).
//
RX   PubMed=8872523; DOI=10.1007/BF02787375;
RA   Kimura Y., Kobari M., Yusa T., Sunamura M., Kimura M., Shimamura H.,
RA   Matsuno S.;
RT   "Establishment of an experimental liver metastasis model by
RT   intraportal injection of a newly derived human pancreatic cancer cell
RT   line (KLM-1).";
RL   Int. J. Pancreatol. 20:43-50(1996).
//
RX   PubMed=11115575; DOI=10.3892/or.8.1.89;
RA   Sun C.-L., Yamato T., Furukawa T., Ohnishi Y., Kijima H., Horii A.;
RT   "Characterization of the mutations of the K-ras, p53, p16, and SMAD4
RT   genes in 15 human pancreatic cancer cell lines.";
RL   Oncol. Rep. 8:89-92(2001).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=22490663; DOI=10.1016/j.bbrc.2012.03.122;
RA   Saiki Y., Yoshino Y., Fujimura H., Manabe T., Kudo Y., Shimada M.,
RA   Mano N., Nakano T., Lee Y., Shimizu S., Oba S., Fujiwara S.,
RA   Shimizu H., Chen N., Nezhad Z.K., Jin G., Fukushige S., Sunamura M.,
RA   Ishida M., Motoi F., Egawa S., Unno M., Horii A.;
RT   "DCK is frequently inactivated in acquired gemcitabine-resistant human
RT   cancer cells.";
RL   Biochem. Biophys. Res. Commun. 421:98-104(2012).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26216984; DOI=10.1073/pnas.1501605112;
RA   Daemen A., Peterson D., Sahu N., McCord R., Du X.-N., Liu B.,
RA   Kowanetz K., Hong R., Moffat J., Gao M., Boudreau A., Mroue R.,
RA   Corson L., O'Brien T., Qing J., Sampath D., Merchant M., Yauch R.L.,
RA   Manning G., Settleman J., Hatzivassiliou G., Evangelista M.;
RT   "Metabolite profiling stratifies pancreatic ductal adenocarcinomas
RT   into subtypes with distinct sensitivities to metabolic inhibitors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//