Cellosaurus cell line RPK-1 (CVCL

Cellosaurus RPK-1 (CVCL_0B31)

Cross-references
Cell line name	RPK-1
Synonyms	RPK1
Accession	CVCL_0B31
Resource Identification Initiative	To cite this cell line use: RPK-1 (RRID:CVCL_0B31)
Comments	Population: Japanese. Selected for resistance to: ChEBI; CHEBI:175901; Gemcitabine (Gemzar). Omics: Transcriptome analysis by microarray. Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations	Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=22490663). Mutation; HGNC; 11998; TP53; Simple; p.Met237Ile (c.711G>A); ClinVar=VCV000142714; Zygosity=Homozygous (PubMed=22490663).
Disease	Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_4717 (PK-1)
Sex of cell	Male
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=22490663; DOI=10.1016/j.bbrc.2012.03.122 Saiki Y., Yoshino Y., Fujimura H., Manabe T., Kudo Y., Shimada M., Mano N., Nakano T., Lee Y., Shimizu S., Oba S., Fujiwara S., Shimizu H., Chen N., Nezhad Z.K., Jin G., Fukushige S., Sunamura M., Ishida M., Motoi F., Egawa S., Unno M., Horii A. DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells. Biochem. Biophys. Res. Commun. 421:98-104(2012)
Cell line databases/resources	cancercelllines; CVCL_0B31 Cell_Model_Passport; SIDM01633
Anatomy/cell type resources	BTO; BTO:0005470
Encyclopedic resources	Wikidata; Q54951154
Gene expression databases	GEO; GSM862565 GEO; GSM862567
Entry history
Entry creation	10-Apr-2015
Last entry update	05-Oct-2023
Version number	14