Cellosaurus cell line RPK-1 (CVCL

Cellosaurus RPK-1 (CVCL_0B31)

Cross-references
Cell line name	RPK-1
Synonyms	RPK1
Accession	CVCL_0B31
Resource Identification Initiative	To cite this cell line use: RPK-1 (RRID:CVCL_0B31)
Comments	Population: Japanese. Selected for resistance to: ChEBI; CHEBI_175901; Gemcitabine (Gemzar). Omics: Transcriptomics; Microarray. Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations	Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=22490663). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met237Ile (c.711G>A); ClinVar=VCV000142714; Zygosity=Homozygous (PubMed=22490663).
Disease	Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_4717 (PK-1)
Sex of cell	Male
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=22490663; DOI=10.1016/j.bbrc.2012.03.122 Yuriko Saiki, Yuki Yoshino, Hiroko Fujimura, Tatsuya Manabe, Yuki Kudo, Miki Shimada, Nariyasu Mano, Tomohiro Nakano, Yoonha Lee, Shinjiro Shimizu, Shinya Oba ...Show all 23 authors... , Sho Fujiwara, Hideyuki Shimizu, Na Chen, Zhaleh Kashkouli Nezhad, Guo Jin, Shinichi Fukushige, Makoto Sunamura, Masaharu Ishida, Fuyuhiko Motoi, Shinichi Egawa, Michiaki Unno, Akira Horii; Show fewer authors DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells. Biochem. Biophys. Res. Commun. 421:98-104(2012)
Cell line databases/resources	cancercelllines; CVCL_0B31 Cell_Model_Passport; SIDM01633
Anatomy/cell type resources	BTO; BTO_0005470
Encyclopedic resources	Wikidata; Q54951154
Gene expression databases	GEO; GSM862565 GEO; GSM862567
Entry history
Entry creation	10-Apr-2015
Last entry update	10-Apr-2025
Version number	16