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Cellosaurus LIM1863 (CVCL_4434)

[Text version]
Cell line name LIM1863
Synonyms Lim1863; LIM 1863; LIM-1863
Accession CVCL_4434
Resource Identification Initiative To cite this cell line use: LIM1863 (RRID:CVCL_4434)
Comments From: Ludwig Institute for Cancer Research, Melbourne Branch; Melbourne; Australia.
Doubling time: 53 hours (PubMed=1427983); 2-3 days (CBA=CBA-0162).
Microsatellite instability: Stable (MSS) (PubMed=19378335).
Omics: Proteomics.
Misspelling: LIM21-1863; Cosmic=948846.
Misspelling: LM1863; Cosmic=1043818.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
HLA typing Source: PubMed=8464898
Class I
HLA-AA*03,11
Disease Colorectal adenocarcinoma (NCIt: C5105)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 74Y
Category Cancer cell line
STR profile Source(s): CBA=CBA-0162

Markers:
AmelogeninX
CSF1PO10
D2S133824
D3S135815
D5S81813
D7S8209,10
D8S117910,14,15
D13S3178,11
D16S53912,13
D18S5113
D19S43314,16
D21S1132
FGA19,21
TH016,9
TPOX8,12
vWA18

Run an STR similarity search on this cell line
Web pages Info; Pawefish; -; https://www.cellosaurus.org/pawefish/ColonCellLineDescriptions/LIM1863.html
Publications

PubMed=3567898
Robert H. Whitehead, Jennifer K. Jones, Anastasia Gabriel, Robyn E. Lukies;
A new colon carcinoma cell line (LIM1863) that grows as organoids with spontaneous differentiation into crypt-like structures in vitro.
Cancer Res. 47:2683-2689(1987)

PubMed=1427983; DOI=10.1038/icb.1992.30
Robert H. Whitehead, Hui-Hua Zhang, Ian P. Hayward;
Retention of tissue-specific phenotype in a panel of colon carcinoma cell lines: relationship to clinical correlates.
Immunol. Cell Biol. 70:227-236(1992)

PubMed=8464898; DOI=10.1073/pnas.90.7.2842; PMCID=PMC46192
Michael J. Browning, Peter Krausa, Andrew J. Rowan, David C. Bicknell, Julia Gwynaeth Bodmer, Walter Fred Bodmer;
Tissue typing the HLA-A locus from genomic DNA by sequence-specific PCR: comparison of HLA genotype and surface expression on colorectal tumor cell lines.
Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993)

PubMed=11226274; DOI=10.1073/pnas.041603298; PMCID=PMC30173
Wael M. Abdel-Rahman, Kanade Katsura, Willem Rens, Patricia A. Gorman, Denise Sheer, David C. Bicknell, Walter Fred Bodmer, Mark J. Arends, Andrew Hamilton Wyllie, Paul A.W. Edwards;
Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement.
Proc. Natl. Acad. Sci. U.S.A. 98:2538-2543(2001)

PubMed=16418264; DOI=10.1073/pnas.0510146103; PMCID=PMC1327731
Ying Liu, Walter Fred Bodmer;
Analysis of p53 mutations and their expression in 56 colorectal cancer cell lines.
Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006)

PubMed=18258742; DOI=10.1073/pnas.0712176105; PMCID=PMC2268141
Muhammad Emaduddin, David C. Bicknell, Walter Fred Bodmer, Stephan M. Feller;
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008)

PubMed=19378335; DOI=10.1002/ijc.24289
Hui-Hua Zhang, Francesca E. Walker, Sara Kiflemariam, Robert H. Whitehead, David Williams, Wayne A. Phillips, Thomas Mikeska, Alexander Dobrovic, Antony Wilks Burgess;
Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf.
Int. J. Cancer 125:297-307(2009)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780; PMCID=PMC2920028
Karin Bracht, Angela M. Nicholls, Ying Liu, Walter Fred Bodmer;
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=29101300; DOI=10.15252/msb.20177701; PMCID=PMC5731344
Martin Frejno, Riccardo Zenezini Chiozzi, Mathias Wilhelm, Heiner Koch, Run-Sheng Zheng, Susan Klaeger, Benjamin Ruprecht, Chen Meng, Karl Kramer, Anna Jarzab, Stephanie Heinzlmeir ...Show all 20 authors... , Elaine Johnstone, Enric Domingo, David James Kerr, Moritz Jesinghaus, Julia Slotta-Huspenina, Wilko Weichert, Stefan Knapp, Stephan M. Feller, Bernhard Kuster; Show fewer authors
Pharmacoproteomic characterisation of human colon and rectal cancer.
Mol. Syst. Biol. 13:951-951(2017)

Cross-references
Cell line collections (Providers) CBA; CBA-0162
Cell line databases/resources cancercelllines; CVCL_4434
ColonAtlas; LIM1863
Anatomy/cell type resources BTO; BTO_0001918
Biological sample resources BioSample; SAMN07624437
Encyclopedic resources Wikidata; Q54902527
Polymorphism and mutation databases Cosmic; 948846
Cosmic; 1043818
Cosmic; 1184327
Cosmic; 1238051
Cosmic; 1482516
Cosmic; 1524337
Cosmic; 1805258
Cosmic; 2760090
IARC_TP53; 21740
Proteomic databases PRIDE; PXD005354
PRIDE; PXD005355
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number36