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Cellosaurus LIM1863 (CVCL_4434)

[Text version]
Cell line name LIM1863
Synonyms Lim1863; LIM 1863; LIM-1863
Accession CVCL_4434
Resource Identification Initiative To cite this cell line use: LIM1863 (RRID:CVCL_4434)
Comments From: Ludwig Institute for Cancer Research, Melbourne Branch; Melbourne; Australia.
Doubling time: 53 hours (PubMed=1427983); 2-3 days (CBA=CBA-0162).
Microsatellite instability: Stable (MSS) (PubMed=19378335).
Omics: Deep proteome analysis.
Misspelling: LIM21-1863; Cosmic=948846.
Misspelling: LM1863; Cosmic=1043818.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
HLA typing Source: PubMed=8464898
Class I
Disease Colorectal adenocarcinoma (NCIt: C5105)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 74Y
Category Cancer cell line
STR profile Source(s): CBA


Run an STR similarity search on this cell line
Web pages https://www.cellosaurus.org/pawefish/ColonCellLineDescriptions/LIM1863.html

Whitehead R.H., Jones J.K., Gabriel A., Lukies R.E.
A new colon carcinoma cell line (LIM1863) that grows as organoids with spontaneous differentiation into crypt-like structures in vitro.
Cancer Res. 47:2683-2689(1987)

PubMed=1427983; DOI=10.1038/icb.1992.30
Whitehead R.H., Zhang H.H., Hayward I.P.
Retention of tissue-specific phenotype in a panel of colon carcinoma cell lines: relationship to clinical correlates.
Immunol. Cell Biol. 70:227-236(1992)

PubMed=8464898; DOI=10.1073/pnas.90.7.2842
Browning M.J., Krausa P., Rowan A.J., Bicknell D.C., Bodmer J.G., Bodmer W.F.
Tissue typing the HLA-A locus from genomic DNA by sequence-specific PCR: comparison of HLA genotype and surface expression on colorectal tumor cell lines.
Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993)

PubMed=11226274; DOI=10.1073/pnas.041603298
Abdel-Rahman W.M., Katsura K., Rens W., Gorman P.A., Sheer D., Bicknell D.C., Bodmer W.F., Arends M.J., Wyllie A.H., Edwards P.A.W.
Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement.
Proc. Natl. Acad. Sci. U.S.A. 98:2538-2543(2001)

PubMed=16418264; DOI=10.1073/pnas.0510146103
Liu Y., Bodmer W.F.
Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines.
Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006)

PubMed=18258742; DOI=10.1073/pnas.0712176105
Emaduddin M., Bicknell D.C., Bodmer W.F., Feller S.M.
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008)

PubMed=19378335; DOI=10.1002/ijc.24289
Zhang H.H., Walker F., Kiflemariam S., Whitehead R.H., Williams D., Phillips W.A., Mikeska T., Dobrovic A., Burgess A.W.
Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf.
Int. J. Cancer 125:297-307(2009)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780
Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=29101300; DOI=10.15252/msb.20177701
Frejno M., Zenezini Chiozzi R., Wilhelm M., Koch H., Zheng R.-S., Klaeger S., Ruprecht B., Meng C., Kramer K., Jarzab A., Heinzlmeir S., Johnstone E., Domingo E., Kerr D., Jesinghaus M., Slotta-Huspenina J., Weichert W., Knapp S., Feller S.M., Kuster B.
Pharmacoproteomic characterisation of human colon and rectal cancer.
Mol. Syst. Biol. 13:951-951(2017)

Cell line collections (Providers) CBA; CBA-0162
Cell line databases/resources cancercelllines; CVCL_4434
ColonAtlas; LIM1863
Anatomy/cell type resources BTO; BTO:0001918
Biological sample resources BioSample; SAMN07624437
Encyclopedic resources Wikidata; Q54902527
Polymorphism and mutation databases Cosmic; 948846
Cosmic; 1043818
Cosmic; 1184327
Cosmic; 1238051
Cosmic; 1482516
Cosmic; 1524337
Cosmic; 1805258
Cosmic; 2760090
IARC_TP53; 21740
Proteomic databases PRIDE; PXD005354
PRIDE; PXD005355
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number33