ID   LIM1863
AC   CVCL_4434
SY   Lim1863; LIM 1863; LIM-1863
DR   BTO; BTO_0001918
DR   BioSample; SAMN07624437
DR   cancercelllines; CVCL_4434
DR   CBA; CBA-0162
DR   ColonAtlas; LIM1863
DR   Cosmic; 948846
DR   Cosmic; 1043818
DR   Cosmic; 1184327
DR   Cosmic; 1238051
DR   Cosmic; 1482516
DR   Cosmic; 1524337
DR   Cosmic; 1805258
DR   Cosmic; 2760090
DR   IARC_TP53; 21740
DR   PRIDE; PXD005354
DR   PRIDE; PXD005355
DR   Wikidata; Q54902527
RX   PubMed=1427983;
RX   PubMed=3567898;
RX   PubMed=8464898;
RX   PubMed=11226274;
RX   PubMed=16418264;
RX   PubMed=18258742;
RX   PubMed=19378335;
RX   PubMed=20606684;
RX   PubMed=29101300;
WW   Info; Pawefish; -; https://www.cellosaurus.org/pawefish/ColonCellLineDescriptions/LIM1863.html
CC   From: Ludwig Institute for Cancer Research, Melbourne Branch; Melbourne; Australia.
CC   Doubling time: 53 hours (PubMed=1427983); 2-3 days (CBA=CBA-0162).
CC   HLA typing: A*03,11 (PubMed=8464898).
CC   Microsatellite instability: Stable (MSS) (PubMed=19378335).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr234His (c.700T>C); ClinVar=VCV000376691; Zygosity=Unspecified (PubMed=16418264; PubMed=19378335).
CC   Omics: Proteomics.
CC   Misspelling: LIM21-1863; Cosmic=948846.
CC   Misspelling: LM1863; Cosmic=1043818.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
ST   Source(s): CBA=CBA-0162
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 8,11
ST   D16S539: 12,13
ST   D18S51: 13
ST   D19S433: 14,16
ST   D21S11: 32
ST   D2S1338: 24
ST   D3S1358: 15
ST   D5S818: 13
ST   D7S820: 9,10
ST   D8S1179: 10,14,15
ST   FGA: 19,21
ST   TH01: 6,9
ST   TPOX: 8,12
ST   vWA: 18
DI   NCIt; C5105; Colorectal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   74Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 36
//
RX   PubMed=1427983; DOI=10.1038/icb.1992.30;
RA   Whitehead R.H., Zhang H.H., Hayward I.P.;
RT   "Retention of tissue-specific phenotype in a panel of colon carcinoma
RT   cell lines: relationship to clinical correlates.";
RL   Immunol. Cell Biol. 70:227-236(1992).
//
RX   PubMed=3567898;
RA   Whitehead R.H., Jones J.K., Gabriel A., Lukies R.E.;
RT   "A new colon carcinoma cell line (LIM1863) that grows as organoids
RT   with spontaneous differentiation into crypt-like structures in
RT   vitro.";
RL   Cancer Res. 47:2683-2689(1987).
//
RX   PubMed=8464898; DOI=10.1073/pnas.90.7.2842; PMCID=PMC46192;
RA   Browning M.J., Krausa P., Rowan A.J., Bicknell D.C., Bodmer J.G.,
RA   Bodmer W.F.;
RT   "Tissue typing the HLA-A locus from genomic DNA by sequence-specific
RT   PCR: comparison of HLA genotype and surface expression on colorectal
RT   tumor cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993).
//
RX   PubMed=11226274; DOI=10.1073/pnas.041603298; PMCID=PMC30173;
RA   Abdel-Rahman W.M., Katsura K., Rens W., Gorman P.A., Sheer D.,
RA   Bicknell D.C., Bodmer W.F., Arends M.J., Wyllie A.H., Edwards P.A.W.;
RT   "Spectral karyotyping suggests additional subsets of colorectal
RT   cancers characterized by pattern of chromosome rearrangement.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:2538-2543(2001).
//
RX   PubMed=16418264; DOI=10.1073/pnas.0510146103; PMCID=PMC1327731;
RA   Liu Y., Bodmer W.F.;
RT   "Analysis of p53 mutations and their expression in 56 colorectal
RT   cancer cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006).
//
RX   PubMed=18258742; DOI=10.1073/pnas.0712176105; PMCID=PMC2268141;
RA   Emaduddin M., Bicknell D.C., Bodmer W.F., Feller S.M.;
RT   "Cell growth, global phosphotyrosine elevation, and c-Met
RT   phosphorylation through Src family kinases in colorectal cancer
RT   cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008).
//
RX   PubMed=19378335; DOI=10.1002/ijc.24289;
RA   Zhang H.-H., Walker F.E., Kiflemariam S., Whitehead R.H., Williams D.,
RA   Phillips W.A., Mikeska T., Dobrovic A., Burgess A.W.;
RT   "Selective inhibition of proliferation in colorectal carcinoma cell
RT   lines expressing mutant APC or activated B-Raf.";
RL   Int. J. Cancer 125:297-307(2009).
//
RX   PubMed=20606684; DOI=10.1038/sj.bjc.6605780; PMCID=PMC2920028;
RA   Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.;
RT   "5-fluorouracil response in a large panel of colorectal cancer cell
RT   lines is associated with mismatch repair deficiency.";
RL   Br. J. Cancer 103:340-346(2010).
//
RX   PubMed=29101300; DOI=10.15252/msb.20177701; PMCID=PMC5731344;
RA   Frejno M., Zenezini Chiozzi R., Wilhelm M., Koch H., Zheng R.-S.,
RA   Klaeger S., Ruprecht B., Meng C., Kramer K., Jarzab A., Heinzlmeir S.,
RA   Johnstone E., Domingo E., Kerr D.J., Jesinghaus M., Slotta-Huspenina J.,
RA   Weichert W., Knapp S., Feller S.M., Kuster B.;
RT   "Pharmacoproteomic characterisation of human colon and rectal
RT   cancer.";
RL   Mol. Syst. Biol. 13:951-951(2017).
//