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Cellosaurus LL/2 (LLC1) (CVCL_4358)

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Cell line name LL/2 (LLC1)
Synonyms LL/2 (LLc1); LL/2(LLc1); LL/2; LL2; LLC1; LLC; Lewis lung carcinoma line 1; Lewis lung carcinoma; Lewis Lung Cancer; Lewis-Lung; Lewis Lung
Accession CVCL_4358
Resource Identification Initiative To cite this cell line use: LL/2 (LLC1) (RRID:CVCL_4358)
Comments Doubling time: 21 hours (PubMed=7226139); 21 hours (CLS=400263).
Omics: Proteomics; HLA class I peptidome.
Omics: Transcriptomics; Microarray.
Caution: Could be identical to 3LL (Cellosaurus=CVCL_5653).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Disease Malignant tumors of the mouse pulmonary system (NCIt: C21769)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Children:
CVCL_F5YJ (EDITGENE Kras (p.G12C) Point Mutation in LLC Cell Line)CVCL_F5YK (EDITGENE Kras, p.G12C & Trp53, p.R172H Point Mutation in LLC Cell Line)CVCL_F6C8 (EDITGENE LLC-CopGFP)
CVCL_F5UR (EDITGENE LLC-FLUC)CVCL_F5YL (EDITGENE Trp53 (p.R172H) Point Mutation in LLC Cell Line)CVCL_E6W9 (Genomeditech LLC1 H_SLC39A6)
CVCL_F1R8 (HyCyte LL/2 (LLC1) KO-mArg2)CVCL_F4JI (HyCyte LL/2 (LLC1) KO-mChchd10)CVCL_E1LR (HyCyte LL/2 (LLC1) KO-mIrf7)
CVCL_F1R9 (HyCyte LL/2 (LLC1) KO-mItgal)CVCL_D6BW (HyCyte LL/2 (LLC1) KO-mKeap1)CVCL_D6BX (HyCyte LL/2 (LLC1) KO-mMdm4)
CVCL_D6BY (HyCyte LL/2 (LLC1) KO-mMif)CVCL_F1RA (HyCyte LL/2 (LLC1) KO-mMlkl)CVCL_F4I7 (HyCyte LL/2 (LLC1) KO-mPim1)
CVCL_F1RB (HyCyte LL/2 (LLC1) KO-mPrmt3)CVCL_E1LS (HyCyte LL/2 (LLC1) KO-mSting1)CVCL_F4FQ (HyCyte LL/2 (LLC1) KO-mTsc2)
CVCL_F1RC (HyCyte LL/2 (LLC1) KO-mZdhhc6)CVCL_F4JS (HyCyte LL/2 (LLC1) mEgfr_p.L860R_c.2579T>G cell line)CVCL_F4MV (HyCyte LL/2 (LLC1) stable cell line for hDLL3 overexpression)
CVCL_F4RH (HyCyte LL/2 (LLC1) stable cell line for hFAP overexpression)CVCL_F4PZ (HyCyte LL/2 (LLC1) stable cell line for mBnip3 overexpression)CVCL_F4NF (HyCyte LL/2 (LLC1) stable cell line for mCxcl12 overexpression)
CVCL_F4MW (HyCyte LL/2 (LLC1) stable cell line for mEspl1 overexpression)CVCL_F4Q4 (HyCyte LL/2 (LLC1) stable cell line for mItgal overexpression)CVCL_F4PC (HyCyte LL/2 (LLC1) stable cell line for mMapkapk2 overexpression)
CVCL_F4TV (HyCyte LL/2 (LLC1) stable cell line for mMet overexpression)CVCL_F4PD (HyCyte LL/2 (LLC1) stable cell line for mPycard overexpression)CVCL_F4N6 (HyCyte LL/2 (LLC1) stable cell line for mSox4 overexpression)
CVCL_F4TI (HyCyte LL/2 (LLC1) stable cell line for mTrim28 overexpression)CVCL_E3HS (HyCyte LL/2 (LLC1)-Luc)CVCL_RA22 (LL/2-eGFP-Puro)
CVCL_RA23 (LL/2-Fluc-Neo/eGFP-Puro)CVCL_RA24 (LL/2-Fluc-Puro)CVCL_RA25 (LL/2-iRFP-Puro)
CVCL_5J40 (LL/2-luc-M38)CVCL_A4CM (LL/2-Luc2)CVCL_RA26 (LL/2-mNIS (monoclonal))
CVCL_RA27 (LL/2-mNIS-Neo/eGFP-Puro)CVCL_RA28 (LL/2-mNIS-Neo/Fluc-Puro)CVCL_RA29 (LL/2-mNIS-Puro)
CVCL_5J02 (LL/2-Red-FLuc)CVCL_H949 (LLAK)CVCL_H948 (LLTC)
CVCL_E0X9 (Ubigene LLC Keap1 KO)CVCL_E0XA (Ubigene LLC Nadk2 KO)
Category Cancer cell line
STR profile Source(s): PubMed=31220119; Ubigene=YC-C018

Markers:
Mouse STR 1-115,17,18
Mouse STR 1-218,19,20
Mouse STR 2-115,16
Mouse STR 3-213,14
Mouse STR 4-220.3,21.3,23.3 (PubMed=31220119)
21.3,23.3 (Ubigene=YC-C018)
Mouse STR 5-516,17 (Ubigene=YC-C018)
16,17,18 (PubMed=31220119)
Mouse STR 6-417,18 (PubMed=31220119)
18 (Ubigene=YC-C018)
Mouse STR 6-714,15,16 (PubMed=31220119)
15 (Ubigene=YC-C018)
Mouse STR 7-126.2,27.2,28.2
Mouse STR 8-116
Mouse STR 11-213.3,14.3,15.3,16
Mouse STR 12-117
Mouse STR 13-117,18
Mouse STR 15-322.3,24.3 (PubMed=31220119)
24.3,25.3 (Ubigene=YC-C018)
Mouse STR 17-214,15,16
Mouse STR 18-315,16
Mouse STR 19-213
Mouse STR X-124,26,28 (PubMed=31220119)
25,25.3 (Ubigene=YC-C018)

Run an STR similarity search on this cell line
Web pages Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/l/cell-lines-detail-352.html
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/lung-cancer-xenograft/ll2-xenograft-model/
Publications

PubMed=7226139; DOI=10.1016/0304-3835(80)90130-5
John S. Bertram, Przemyslaw Janik;
Establishment of a cloned line of Lewis lung carcinoma cells adapted to cell culture.
Cancer Lett. 11:63-73(1980)

DOI=10.4051/ibc.2010.2.4.0014
Kaori Yoshino, Kaoru Saijo, Chikako Noro, Yukio Nakamura;
Development of a simple method to determine the mouse strain from which cultured cell lines originated.
Interdisciplinary Bio Cent. 2:14.1-14.9(2010)

PubMed=28599420; DOI=10.3892/ol.2017.5877; PMCID=PMC5453008
Vaidotas Stankevicius, Karolina Kuodyte, Diana Schveigert, Danute Bulotiene, Tomas Paulauskas, Kristina Daniunaite, Kestutis Suziedelis;
Gene and miRNA expression profiles of mouse Lewis lung carcinoma LLC1 cells following single or fractionated dose irradiation.
Oncol. Lett. 13:4190-4200(2017)

PubMed=30084848; DOI=10.1038/sdata.2018.157; PMCID=PMC6080492
Heiko Schuster, Wen-Guang Shao, Tobias Weiss, Patrick Gino Angelo Pedrioli, Patrick Roth, Michael Weller, David S. Campbell, Eric W. Deutsch, Robert L. Moritz, Oliver Planz, Hans-Georg Rammensee ...Show all 13 authors... , Ruedi Aebersold, Etienne Caron; Show fewer authors
A tissue-based draft map of the murine MHC class I immunopeptidome.
Sci. Data 5:180157.1-180157.11(2018)

PubMed=31220119; DOI=10.1371/journal.pone.0218412; PMCID=PMC6586308
Jamie L. Almeida, Aleksandra Dakic, Karin Kindig, Maikan Kone, Deborah Lee Dormady Letham, Scott Langdon, Ruth Peat, Jayamalini Holding-Pillai, Erin M. Hall, Mark Ladd, Megan D. Shaffer ...Show all 23 authors... , Heath Berg, Jin-Liang Li, Georges Wigger, Steve Lund, Carolyn R. Steffen, Barbara B. Fransway, Bob Geraghty, Manuela Natoli, Beth A. Bauer, Susanne M. Gollin, Dale W. Lewis, Yvonne A. Reid; Show fewer authors
Interlaboratory study to validate a STR profiling method for intraspecies identification of mouse cell lines.
PLoS ONE 14:e0218412.1-e0218412.24(2019)

Cross-references
Cell line collections (Providers) AddexBio; C0016030/5000
ATCC; CRL-1642
BCRC; 60050
BCRJ; 0145
CLS; 305311
CLS; 400263 - Discontinued
ECACC; 90020104
EDITGENE; EDC00260
Hysigen; TCM-C742
IZSLER; BS TCL 216
KCB; KCB 200781YJ
NCBI_Iran; C587
NCI-DCTD; Lewis Lung
RCB; RCB0558
TKG; TKG 0153
Ubigene; YC-C018
Cell line databases/resources CLO; CLO_0007325
CLO; CLO_0050167
CLDB; cl3208
CCRID; 1101MOU-PUMC000673
CCRID; 3101MOUTCM7
TOKU-E; 2205
Anatomy/cell type resources BTO; BTO_0000181
BTO; BTO_0000745
Biological sample resources BioSample; SAMN11397632
CRISP screens repositories BioGRID_ORCS_Cell_line; 1628
Chemistry resources ChEMBL-Cells; CHEMBL3307859
ChEMBL-Targets; CHEMBL614088
PubChem_Cell_line; CVCL_4358
Encyclopedic resources Wikidata; Q54902678
Gene expression databases GEO; GSE84108
Proteomic databases PRIDE; PXD008733
Entry history
Entry creation04-Apr-2012
Last entry update25-Jun-2026
Version number38