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Cellosaurus ICR-2A (CVCL_4345)

[Text version]
Cell line name ICR-2A
Synonyms ICR 2A; ICR2A; RPH 68.2A; RPH68.2A
Accession CVCL_4345
Resource Identification Initiative To cite this cell line use: ICR-2A (RRID:CVCL_4345)
Comments Group: Amphibian cell line.
Group: Haploid karyotype cell line.
Doubling time: ~40 hours (PubMed=5263768); 48 hours (PubMed=3500873).
Species of origin Lithobates pipiens (Northern leopard frog) (Rana pipiens) (NCBI Taxonomy: 8404)
Hierarchy Children:
CVCL_T701 (DRP 153)CVCL_T700 (DRP 36)CVCL_5G40 (ICR B20)
Sex of cell Sex unspecified
Age at sampling Embryo
Category Spontaneously immortalized cell line

PubMed=5263768; DOI=10.1073/pnas.65.2.337
Freed J.J., Mezger-Freed L.
Stable haploid cultured cell lines from frog embryos.
Proc. Natl. Acad. Sci. U.S.A. 65:337-344(1970)

Freed J.J.
Cellular heredity in haploid cultures of somatic cells. Progress Report, December 1971-November 1972.
(In) Office of Scientific and Technical Information, Technical report COO-3110-8; pp.1-18; U.S. Department of Energy; Oak Ridge (1972)

Mezger-Freed L.
Effect of mutagens on BUdR resistance in haploid cells: genetic or epigenetic.
(In) Office of Scientific and Technical Information, Technical report COO-3110-7/CONF-721055-1; pp.1-23; U.S. Department of Energy; Oak Ridge (1972)

PubMed=4543150; DOI=10.1002/jcp.1040820208
Freed J.J., Mezger-Freed L.
Origin of thymidine kinase deficient (TK-) haploid frog cells via an intermediate thymidine transport deficient (TT-) phenotype.
J. Cell. Physiol. 82:199-212(1973)

PubMed=301813; DOI=10.1007/BF00328437
Mezger-Freed L.
Chromosomal evolution in a haploid frog cell line: implications for the origin of karyotypic variants.
Chromosoma 62:1-15(1977)

PubMed=307556; DOI=10.1002/jcp.1040960309
Chinchar G.D., Sinclair J.H.
Amphibian cells in culture. I. Nutritional studies.
J. Cell. Physiol. 96:333-342(1978)

PubMed=307557; DOI=10.1002/jcp.1040960310
Chinchar G.D., Sinclair J.H.
Amphibian cells in culture. II. Isolation of drug-resistant variants and an asparagine-independent variant.
J. Cell. Physiol. 96:343-354(1978)

PubMed=3500873; DOI=10.1016/0014-5793(87)81145-6
Chao C.C.-K., Lin-Chao S.
Loss of inducible photorepair in a frog cell line hypersensitive to solar UV light.
FEBS Lett. 225:133-138(1987)

PubMed=2569015; DOI=10.1080/09553008914551281
Rosenstein B.S.
Inhibition and recovery of semiconservative DNA synthesis in normal and solar UV sensitive ICR 2A frog cell lines following the induction of non-dimer DNA damage by sunlamp UV greater than 315 nm.
Int. J. Radiat. Biol. 56:131-138(1989)

PubMed=2910704; DOI=10.1002/em.2850130106
Rosenstein B.S.
DNA strand breakage in normal and solar ultraviolet-sensitive ICR 2A frog cell lines exposed to solar ultraviolet wavelengths.
Environ. Mol. Mutagen. 13:50-53(1989)

Cell line collections (Providers) ATCC; CCL-145
ECACC; 89072615
Cell line databases/resources CLO; CLO_0004338
CLDB; cl1800
Encyclopedic resources Wikidata; Q54897236
Entry history
Entry creation04-Apr-2012
Last entry update21-Mar-2023
Version number11