ID   ICR-2A
AC   CVCL_4345
SY   ICR 2A; ICR2A; RPH 68.2A; RPH68.2A
DR   CLO; CLO_0004338
DR   CLDB; cl1800
DR   ATCC; CCL-145
DR   ECACC; 89072615
DR   IZSLER; BS CL 191
DR   Wikidata; Q54897236
RX   DOI=10.2172/4607053;
RX   DOI=10.2172/4623769;
RX   PubMed=301813;
RX   PubMed=307556;
RX   PubMed=307557;
RX   PubMed=2569015;
RX   PubMed=2910704;
RX   PubMed=3500873;
RX   PubMed=4543150;
RX   PubMed=5263768;
CC   Group: Amphibian cell line.
CC   Group: Haploid karyotype cell line.
CC   Doubling time: ~40 hours (PubMed=5263768); 48 hours (PubMed=3500873).
OX   NCBI_TaxID=8404; ! Lithobates pipiens (Northern leopard frog)
SX   Sex unspecified
AG   Embryo
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 21-03-23; Version: 11
//
RX   DOI=10.2172/4607053;
RA   Freed J.J.;
RT   "Cellular heredity in haploid cultures of somatic cells. Progress
RT   Report, December 1971-November 1972.";
RL   (In) Office of Scientific and Technical Information, Technical report COO-3110-8; pp.1-18; U.S. Department of Energy; Oak Ridge (1972).
//
RX   DOI=10.2172/4623769;
RA   Mezger-Freed L.;
RT   "Effect of mutagens on BUdR resistance in haploid cells: genetic or
RT   epigenetic.";
RL   (In) Office of Scientific and Technical Information, Technical report COO-3110-7/CONF-721055-1; pp.1-23; U.S. Department of Energy; Oak Ridge (1972).
//
RX   PubMed=301813; DOI=10.1007/BF00328437;
RA   Mezger-Freed L.;
RT   "Chromosomal evolution in a haploid frog cell line: implications for
RT   the origin of karyotypic variants.";
RL   Chromosoma 62:1-15(1977).
//
RX   PubMed=307556; DOI=10.1002/jcp.1040960309;
RA   Chinchar G.D., Sinclair J.H.;
RT   "Amphibian cells in culture. I. Nutritional studies.";
RL   J. Cell. Physiol. 96:333-342(1978).
//
RX   PubMed=307557; DOI=10.1002/jcp.1040960310;
RA   Chinchar G.D., Sinclair J.H.;
RT   "Amphibian cells in culture. II. Isolation of drug-resistant variants
RT   and an asparagine-independent variant.";
RL   J. Cell. Physiol. 96:343-354(1978).
//
RX   PubMed=2569015; DOI=10.1080/09553008914551281;
RA   Rosenstein B.S.;
RT   "Inhibition and recovery of semiconservative DNA synthesis in normal
RT   and solar UV sensitive ICR 2A frog cell lines following the induction
RT   of non-dimer DNA damage by sunlamp UV greater than 315 nm.";
RL   Int. J. Radiat. Biol. 56:131-138(1989).
//
RX   PubMed=2910704; DOI=10.1002/em.2850130106;
RA   Rosenstein B.S.;
RT   "DNA strand breakage in normal and solar ultraviolet-sensitive ICR 2A
RT   frog cell lines exposed to solar ultraviolet wavelengths.";
RL   Environ. Mol. Mutagen. 13:50-53(1989).
//
RX   PubMed=3500873; DOI=10.1016/0014-5793(87)81145-6;
RA   Chao C.C.-K., Lin-Chao S.;
RT   "Loss of inducible photorepair in a frog cell line hypersensitive to
RT   solar UV light.";
RL   FEBS Lett. 225:133-138(1987).
//
RX   PubMed=4543150; DOI=10.1002/jcp.1040820208;
RA   Freed J.J., Mezger-Freed L.;
RT   "Origin of thymidine kinase deficient (TK-) haploid frog cells via an
RT   intermediate thymidine transport deficient (TT-) phenotype.";
RL   J. Cell. Physiol. 82:199-212(1973).
//
RX   PubMed=5263768; DOI=10.1073/pnas.65.2.337;
RA   Freed J.J., Mezger-Freed L.;
RT   "Stable haploid cultured cell lines from frog embryos.";
RL   Proc. Natl. Acad. Sci. U.S.A. 65:337-344(1970).
//