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Cellosaurus RGC-5 (CVCL_4059)

[Text version]
Cell line name RGC-5
Synonyms RGC5
Accession CVCL_4059
Resource Identification Initiative To cite this cell line use: RGC-5 (RRID:CVCL_4059)
Comments Group: Patented cell line.
Problematic cell line: Misidentified. Originally thought to be of rat origin but found to be from mouse (PubMed=19443730; PubMed=24664692). Is probably identical to 661W (PubMed=23975727; PubMed=24021353). But the originator of the 661W cell is partially contesting this claim (PubMed=24472671).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00472.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-6600.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Eye, retina; UBERON=UBERON_0000966.
Cell type: Retinal cone cell; CL=CL_0000573.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6N transgenic.
Hierarchy Parent: CVCL_6240 (661W)
Sex of cell Male
Category Transformed cell line
Web pages http://cellbiology.med.unsw.edu.au/units/lab/cells/cell_RGC5.htm

PubMed=11165366; DOI=10.1016/S0169-328X(00)00224-2
Krishnamoorthy R.R., Agarwal P., Prasanna G., Vopat K., Lambert W.S., Sheedlo H.J., Pang I.-H., Shade D.L., Wordinger R.J., Yorio T., Clark A.F., Agarwal N.
Characterization of a transformed rat retinal ganglion cell line.
Brain Res. Mol. Brain Res. 86:1-12(2001)

Levin L.A.
In vitro-differentiated retinal ganglion cells and method for producing same.
Patent number US7303915, 04-Dec-2007

PubMed=19443730; DOI=10.1167/iovs.09-3484
Van Bergen N.J., Wood J.P.M., Chidlow G., Trounce I.A., Casson R.J., Ju W.-K., Weinreb R.N., Crowston J.G.
Recharacterization of the RGC-5 retinal ganglion cell line.
Invest. Ophthalmol. Vis. Sci. 50:4267-4272(2009)

PubMed=23975727; DOI=10.1167/iovs.13-12085
Krishnamoorthy R.R., Clark A.F., Daudt D., Vishwanatha J.K., Yorio T.
A forensic path to RGC-5 cell line identification: lessons learned.
Invest. Ophthalmol. Vis. Sci. 54:5712-5719(2013)

PubMed=24021353; DOI=10.1016/j.exer.2013.08.002
Clark A.F., Tamm E.R., Al-Ubaidi M.R., Hollyfield J.G.
On the use of immortalized ocular cell lines in vision research: the unfortunate story of RGC-5.
Exp. Eye Res. 116:433-433(2013)

PubMed=24472671; DOI=10.1016/j.exer.2013.10.012
Al-Ubaidi M.R.
RGC-5: are they really 661W? The saga continues.
Exp. Eye Res. 119:115-115(2014)

PubMed=24664692; DOI=10.1007/978-1-4614-3209-8_19
Sippl C., Tamm E.R.
What is the nature of the RGC-5 cell line?
Adv. Exp. Med. Biol. 801:145-154(2014)

PubMed=29203899; DOI=10.1038/s41598-017-17241-0
Sayyad Z., Sirohi K., Radha V., Swarup G.
661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively.
Sci. Rep. 7:16855-16855(2017)

Cell line databases/resources TOKU-E; 3594
Anatomy/cell type resources BTO; BTO:0005118
Biological sample resources BioSample; SAMN03151607
Encyclopedic resources Wikidata; Q54950255
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number23