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Cellosaurus 661W (CVCL_6240)

[Text version]
Cell line name 661W
Synonyms 661w; 661 W
Accession CVCL_6240
Resource Identification Initiative To cite this cell line use: 661W (RRID:CVCL_6240)
Comments Doubling time: ~24 hours (PubMed=12407171).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Proteome analysis by 2D-DE/MS.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Eye, retina; UBERON=UBERON_0000966.
Cell type: Retinal cone cell; CL=CL_0000573.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6N transgenic.
Hierarchy Children:
CVCL_4059 (RGC-5)
Sex of cell Male
Category Transformed cell line

PubMed=11243878; DOI=10.1006/bbrc.2001.4501
Crawford M.J., Krishnamoorthy R.R., Rudick V.L., Collier R.J., Kapin M., Aggarwal B.B., Al-Ubaidi M.R., Agarwal N.
Bcl-2 overexpression protects photooxidative stress-induced apoptosis of photoreceptor cells via NF-kappaB preservation.
Biochem. Biophys. Res. Commun. 281:1304-1312(2001)

Tuohy G., Millington-Ward S., Kenna P.F., Humphries P., Farrar G.J.
Sensitivity of photoreceptor-derived cell line (661W) to baculoviral p35, Z-VAD.FMK, and Fas-associated death domain.
Invest. Ophthalmol. Vis. Sci. 43:3583-3589(2002)

PubMed=14985288; DOI=10.1167/iovs.03-1114
Tan E., Ding X.-Q., Saadi A., Agarwal N., Naash M.I., Al-Ubaidi M.R.
Expression of cone-photoreceptor-specific antigens in a cell line derived from retinal tumors in transgenic mice.
Invest. Ophthalmol. Vis. Sci. 45:764-768(2004)

PubMed=18188958; DOI=10.1007/978-0-387-74904-4_35
Al-Ubaidi M.R., Matsumoto H., Kurono S., Singh A.
Proteomics profiling of the cone photoreceptor cell line, 661W.
Adv. Exp. Med. Biol. 613:301-311(2008)

PubMed=23975727; DOI=10.1167/iovs.13-12085
Krishnamoorthy R.R., Clark A.F., Daudt D., Vishwanatha J.K., Yorio T.
A forensic path to RGC-5 cell line identification: lessons learned.
Invest. Ophthalmol. Vis. Sci. 54:5712-5719(2013)

PubMed=26854824; DOI=10.1016/j.exer.2016.01.016
Pfeffer B.A., Xu L.-B., Porter N.A., Rao S.R., Fliesler S.J.
Differential cytotoxic effects of 7-dehydrocholesterol-derived oxysterols on cultured retina-derived cells: dependence on sterol structure, cell type, and density.
Exp. Eye Res. 145:297-316(2016)

PubMed=29203899; DOI=10.1038/s41598-017-17241-0
Sayyad Z., Sirohi K., Radha V., Swarup G.
661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively.
Sci. Rep. 7:16855-16855(2017)

PubMed=31024622; DOI=10.3389/fgene.2019.00308
Wheway G., Nazlamova L., Turner D., Cross S.
661W photoreceptor cell line as a cell model for studying retinal ciliopathies.
Front. Genet. 10:308.1-308.14(2019)

Sanchez-Bretano A., Suen T.-C., Baba K., DeBruyne J.P., Tosini G.
Melatonin receptor heterodimerization in a photoreceptor-like cell line endogenously expressing melatonin receptors.
Mol. Vis. 25:791-799(2019)

Cell line databases/resources Lonza; 336
Anatomy/cell type resources BTO; BTO:0001554
Chemistry resources ChEMBL-Cells; CHEMBL4483169
ChEMBL-Targets; CHEMBL4483223
PubChem_Cell_line; CVCL_6240
Encyclopedic resources Wikidata; Q54604409
Gene expression databases GEO; GSE119190
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number14