ID   RGC-5
AC   CVCL_4059
DR   BTO; BTO:0005118
DR   BioSample; SAMN03151607
DR   TOKU-E; 3594
DR   Wikidata; Q54950255
RX   Patent=US7303915;
RX   PubMed=11165366;
RX   PubMed=19443730;
RX   PubMed=23975727;
RX   PubMed=24021353;
RX   PubMed=24472671;
RX   PubMed=24664692;
RX   PubMed=29203899;
CC   Group: Patented cell line.
CC   Problematic cell line: Misidentified. Originally thought to be of rat origin but found to be from mouse (PubMed=19443730; PubMed=24664692). Is probably identical to 661W (PubMed=23975727; PubMed=24021353). But the originator of the 661W cell is partially contesting this claim (PubMed=24472671).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00472.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-6600.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Eye, retina; UBERON=UBERON_0000966.
CC   Cell type: Retinal cone cell; CL=CL_0000573.
CC   Breed/subspecies: C57BL/6N transgenic.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_6240 ! 661W
SX   Male
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 23
RX   Patent=US7303915;
RA   Levin L.A.;
RT   "In vitro-differentiated retinal ganglion cells and method for
RT   producing same.";
RL   Patent number US7303915, 04-Dec-2007.
RX   PubMed=11165366; DOI=10.1016/S0169-328X(00)00224-2;
RA   Krishnamoorthy R.R., Agarwal P., Prasanna G., Vopat K., Lambert W.S.,
RA   Sheedlo H.J., Pang I.-H., Shade D.L., Wordinger R.J., Yorio T.,
RA   Clark A.F., Agarwal N.;
RT   "Characterization of a transformed rat retinal ganglion cell line.";
RL   Brain Res. Mol. Brain Res. 86:1-12(2001).
RX   PubMed=19443730; DOI=10.1167/iovs.09-3484;
RA   Van Bergen N.J., Wood J.P.M., Chidlow G., Trounce I.A., Casson R.J.,
RA   Ju W.-K., Weinreb R.N., Crowston J.G.;
RT   "Recharacterization of the RGC-5 retinal ganglion cell line.";
RL   Invest. Ophthalmol. Vis. Sci. 50:4267-4272(2009).
RX   PubMed=23975727; DOI=10.1167/iovs.13-12085;
RA   Krishnamoorthy R.R., Clark A.F., Daudt D., Vishwanatha J.K., Yorio T.;
RT   "A forensic path to RGC-5 cell line identification: lessons learned.";
RL   Invest. Ophthalmol. Vis. Sci. 54:5712-5719(2013).
RX   PubMed=24021353; DOI=10.1016/j.exer.2013.08.002;
RA   Clark A.F., Tamm E.R., Al-Ubaidi M.R., Hollyfield J.G.;
RT   "On the use of immortalized ocular cell lines in vision research: the
RT   unfortunate story of RGC-5.";
RL   Exp. Eye Res. 116:433-433(2013).
RX   PubMed=24472671; DOI=10.1016/j.exer.2013.10.012;
RA   Al-Ubaidi M.R.;
RT   "RGC-5: are they really 661W? The saga continues.";
RL   Exp. Eye Res. 119:115-115(2014).
RX   PubMed=24664692; DOI=10.1007/978-1-4614-3209-8_19;
RA   Sippl C., Tamm E.R.;
RT   "What is the nature of the RGC-5 cell line?";
RL   Adv. Exp. Med. Biol. 801:145-154(2014).
RX   PubMed=29203899; DOI=10.1038/s41598-017-17241-0;
RA   Sayyad Z., Sirohi K., Radha V., Swarup G.;
RT   "661W is a retinal ganglion precursor-like cell line in which
RT   glaucoma-associated optineurin mutants induce cell death
RT   selectively.";
RL   Sci. Rep. 7:16855-16855(2017).