Cellosaurus cell line JCA-1 (CVCL

Cellosaurus JCA-1 (CVCL_4015)

[Text version]

Cell line name

JCA-1

Synonyms

JCA1

Accession

CVCL_4015

Resource Identification Initiative

To cite this cell line use: JCA-1 (RRID:CVCL_4015)

Comments

Problematic cell line: Contaminated. Shown to be a T24 derivative (PubMed=11304728; PubMed=11522622; PubMed=20143388; CelloPub=CLPUB00698). Originally thought to originate from a 67 year old male patient with prostate carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00216.
Population: Caucasian; Swedish.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.

Sequence variations

Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (PubMed=11304728; PubMed=11522622).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (PubMed=11304728; PubMed=11522622).

Disease

Bladder carcinoma (NCIt: C4912)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_0554 (T24)

Sex of cell

Female

Age at sampling

82Y

Category

Cancer cell line

STR profile

Source(s): PubMed=11304728; PubMed=11522622

Markers:

Amelogenin	X
D3S1358	16
D5S818	10,12
D7S820	10,11
D8S1179	14
D13S317	12
D18S51	16,18
D21S11	29
FGA	22
vWA	17

Web pages

Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx

Publications

PubMed=2195744; DOI=10.1016/0090-4295(90)80319-I
Junro Muraki, Joseph C. Addonizio, Muhammad S. Choudhury, Joel Fischer, Majid Eshghi, Marianna M. Davidian, Lawrence R. Shapiro, Patrick L. Wilmot, George R. Nagamatsu, Jen-Wei Chiao;
Establishment of new human prostatic cancer cell line (JCA-1).
Urology 36:79-84(1990)

PubMed=11304728; DOI=10.1002/pros.1045
Adrie van Bokhoven, Marileila Varella-Garcia, Christopher T. Korch, Daphne Hessels, Gary J. Miller;
Widely used prostate carcinoma cell lines share common origins.
Prostate 47:36-51(2001)

PubMed=11522622
Adrie van Bokhoven, Marileila Varella-Garcia, Christopher T. Korch, Gary J. Miller;
TSU-Pr1 and JCA-1 cells are derivatives of T24 bladder carcinoma cells and are not of prostatic origin.
Cancer Res. 61:6340-6344(2001)

CLPUB00698
Adrie van Bokhoven;
Models for prostate cancer. Molecular characterization and critical appraisal of human prostate carcinoma cell lines.
Thesis PhD (2004); Katholieke Universiteit Nijmegen; Nijmegen; Netherlands

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_4015

Biological sample resources

BioSample; SAMN03151947

Encyclopedic resources

Wikidata; Q54898538

Entry history

Entry creation

04-Apr-2012

Last entry update

10-Apr-2025

Version number