ID   JCA-1
AC   CVCL_4015
SY   JCA1
DR   BioSample; SAMN03151947
DR   cancercelllines; CVCL_4015
DR   Wikidata; Q54898538
RX   CelloPub=CLPUB00698;
RX   PubMed=2195744;
RX   PubMed=11304728;
RX   PubMed=11522622;
RX   PubMed=20143388;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a T24 derivative (PubMed=11304728; PubMed=11522622; PubMed=20143388; CelloPub=CLPUB00698). Originally thought to originate from a 67 year old male patient with prostate carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00216.
CC   Population: Caucasian; Swedish.
CC   Sequence variation: Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (PubMed=11304728; PubMed=11522622).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (PubMed=11304728; PubMed=11522622).
CC   Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
ST   Source(s): PubMed=11304728; PubMed=11522622
ST   Amelogenin: X
ST   D13S317: 12
ST   D18S51: 16,18
ST   D21S11: 29
ST   D3S1358: 16
ST   D5S818: 10,12
ST   D7S820: 10,11
ST   D8S1179: 14
ST   FGA: 22
ST   vWA: 17
DI   NCIt; C4912; Bladder carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0554 ! T24
SX   Female
AG   82Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 28
//
RX   CelloPub=CLPUB00698;
RA   van Bokhoven, Adrie
RT   "Models for prostate cancer. Molecular characterization and critical
RT   appraisal of human prostate carcinoma cell lines.";
RL   Thesis PhD (2004); Katholieke Universiteit Nijmegen; Nijmegen; Netherlands.
//
RX   PubMed=11304728; DOI=10.1002/pros.1045;
RA   van Bokhoven, Adrie
RA   Varella-Garcia, Marileila
RA   Korch, Christopher T.
RA   Hessels, Daphne
RA   Miller, Gary J.
RT   "Widely used prostate carcinoma cell lines share common origins.";
RL   Prostate 47:36-51(2001).
//
RX   PubMed=11522622;
RA   van Bokhoven, Adrie
RA   Varella-Garcia, Marileila
RA   Korch, Christopher T.
RA   Miller, Gary J.
RT   "TSU-Pr1 and JCA-1 cells are derivatives of T24 bladder carcinoma
RT   cells and are not of prostatic origin.";
RL   Cancer Res. 61:6340-6344(2001).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=2195744; DOI=10.1016/0090-4295(90)80319-I;
RA   Muraki, Junro
RA   Addonizio, Joseph C.
RA   Choudhury, Muhammad S.
RA   Fischer, Joel
RA   Eshghi, Majid
RA   Davidian, Marianna M.
RA   Shapiro, Lawrence R.
RA   Wilmot, Patrick L.
RA   Nagamatsu, George R.
RA   Chiao, Jen-Wei
RT   "Establishment of new human prostatic cancer cell line (JCA-1).";
RL   Urology 36:79-84(1990).
//