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Cellosaurus TSU-Pr1 (CVCL_4014)

[Text version]
Cell line name TSU-Pr1
Synonyms Tsu-Pr1; TSU-PR1; TSUpr1; TSU
Accession CVCL_4014
Resource Identification Initiative To cite this cell line use: TSU-Pr1 (RRID:CVCL_4014)
Comments Problematic cell line: Contaminated. Shown to be a T24 derivative (PubMed=11304728; PubMed=11522622; PubMed=20143388; CelloPub=CLPUB00698). Originally thought to originate from a 73 year old male patient with a prostate carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00280.
Population: Caucasian; Swedish.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; 5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (PubMed=11304728; PubMed=11522622).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (PubMed=11304728; PubMed=11522622).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0554 (T24)
CVCL_M904 (TSU-Pr1-B1)CVCL_M134 (TsuGK27)
Sex of cell Female
Age at sampling 82Y
Category Cancer cell line
STR profile Source(s): PubMed=11304728; PubMed=11522622


Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx

PubMed=3586177; DOI=10.1016/S0022-5347(17)44488-0
Iizumi T., Yazaki T., Kanoh S., Kondo I., Koiso K.
Establishment of a new prostatic carcinoma cell line (TSU-Pr1).
J. Urol. 137:1304-1306(1987)

Isaacs W.B., Carter B.S., Ewing C.M.
Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles.
Cancer Res. 51:4716-4720(1991)

PubMed=9018337; DOI=10.1002/(SICI)1097-0045(19970101)30:1<58::AID-PROS9>3.0.CO;2-H
Webber M.M., Bello D., Quader S.T.A.
Immortalized and tumorigenic adult human prostatic epithelial cell lines: characteristics and applications Part 2. Tumorigenic cell lines.
Prostate 30:58-64(1997)

PubMed=10972993; DOI=10.1002/1098-2744(200008)28:4<236::AID-MC6>3.0.CO;2-H
Rauh-Adelmann C., Lau K.-M., Sabeti N., Long J.P., Mok S.C., Ho S.-M.
Altered expression of BRCA1, BRCA2, and a newly identified BRCA2 exon 12 deletion variant in malignant human ovarian, prostate, and breast cancer cell lines.
Mol. Carcinog. 28:236-246(2000)

PubMed=11304728; DOI=10.1002/pros.1045
van Bokhoven A., Varella-Garcia M., Korch C.T., Hessels D., Miller G.J.
Widely used prostate carcinoma cell lines share common origins.
Prostate 47:36-51(2001)

van Bokhoven A., Varella-Garcia M., Korch C.T., Miller G.J.
TSU-Pr1 and JCA-1 cells are derivatives of T24 bladder carcinoma cells and are not of prostatic origin.
Cancer Res. 61:6340-6344(2001)

PubMed=12725112; DOI=10.1385/1-59259-372-0:21
Russell P.J., Kingsley E.A.
Human prostate cancer cell lines.
Methods Mol. Med. 81:21-39(2003)

van Bokhoven A.
Models for prostate cancer. Molecular characterization and critical appraisal of human prostate carcinoma cell lines.
Thesis PhD (2004), Katholieke Universiteit Nijmegen, Netherlands

PubMed=16271951; DOI=10.1016/j.cancergencyto.2005.04.010
Kim M.S., Kim S.H., Kim H.J., Hoang I.N., Oh W.M., Koh J.T., Park H.O., Jeong J.Y., Kim W.J., Lee E.J., Koh J.Y., Kim B.Y., Jensen R.H.
Characterization of the TSU-PR1 cell line by chromosome painting and flow cytometry.
Cancer Genet. Cytogenet. 163:17-22(2005)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cell line databases/resources cancercelllines; CVCL_4014
Anatomy/cell type resources BTO; BTO:0001065
Biological sample resources BioSample; SAMN03151952
Encyclopedic resources Wikidata; Q54973170
Polymorphism and mutation databases Cosmic; 704847
Cosmic; 869158
Cosmic; 921049
Cosmic; 922552
Cosmic; 923958
Cosmic; 948073
Cosmic; 1218867
Cosmic; 2444243
IARC_TP53; 753
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number26