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Cellosaurus COLO 38 (CVCL_3934)

[Text version]
Cell line name COLO 38
Synonyms Colo-38; Colo 38; COLO #38; Colo38; COLO38; Colorado 38
Accession CVCL_3934
Resource Identification Initiative To cite this cell line use: COLO 38 (RRID:CVCL_3934)
Comments Problematic cell line: Contaminated. Shown to be a M14 derivative (ICLAC). Originally thought to originate from a 67 year old female patient with a melanoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00556.
Population: Caucasian.
Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=24732172).
  • Mutation; HGNC; 1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1395 (M14)
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line
STR profile Source(s): ICLAC


Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx

Quinn L.A., Woods L.K., Merrick S.B., Arabasz N.M., Moore G.E.
Cytogenetic analysis of twelve human malignant melanoma cell lines.
J. Natl. Cancer Inst. 59:301-307(1977)

Sharma B.
In vitro immunization against human tumor cells with tumor cell fractions.
Cancer Res. 37:4660-4668(1977)

PubMed=15661905; DOI=10.4049/jimmunol.174.3.1462
Chang C.-C., Campoli M., Restifo N.P., Wang X.-H., Ferrone S.
Immune selection of hot-spot beta 2-microglobulin gene mutations, HLA-A2 allospecificity loss, and antigen-processing machinery component down-regulation in melanoma cells derived from recurrent metastases following immunotherapy.
J. Immunol. 174:1462-1471(2005)

PubMed=24732172; DOI=10.18632/oncotarget.1878
Sabbatino F., Wang Y.-Y., Wang X.-H., Flaherty K.T., Yu L., Pepin D., Scognamiglio G., Pepe S., Kirkwood J.M., Cooper Z.A., Frederick D.T., Wargo J.A., Ferrone S., Ferrone C.R.
PDGFRalpha up-regulation mediated by sonic hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation.
Oncotarget 5:1926-1941(2014)

Cell line collections (Providers) CLS; 300151 - Discontinued
Cell line databases/resources cancercelllines; CVCL_3934
Anatomy/cell type resources BTO; BTO:0002941
Encyclopedic resources Wikidata; Q54814108
Polymorphism and mutation databases Cosmic; 928682
Cosmic; 1477405
Cosmic; 2757118
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number23