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Cellosaurus COLO 38 (CVCL_3934)

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Cell line name COLO 38
Synonyms Colo-38; Colo 38; COLO #38; Colo38; COLO38; Colorado 38
Accession CVCL_3934
Resource Identification Initiative To cite this cell line use: COLO 38 (RRID:CVCL_3934)
Comments Problematic cell line: Contaminated. Shown to be a M14 derivative (ICLAC). Originally thought to originate from a 67 year old female patient with a melanoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00556.
Population: Caucasian.
Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=24732172).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1395 (M14)
Children:
CVCL_A1FC (COLO 38R)
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line
STR profile Source(s): ICLAC

Markers:
AmelogeninX
CSF1PO11
D5S81811,12
D7S8208,10
D13S31712
D16S5399,13
TH016,7
TPOX8,11
vWA16,18

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Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

DOI=10.1093/jnci/59.2.301
Laurie A. Quinn, Linda K. Woods, S.B. Merrick, N.M. Arabasz, George Eugene Moore;
Cytogenetic analysis of twelve human malignant melanoma cell lines.
J. Natl. Cancer Inst. 59:301-307(1977)

PubMed=72600
Brahma Sharma;
In vitro immunization against human tumor cells with tumor cell fractions.
Cancer Res. 37:4660-4668(1977)

PubMed=15661905; DOI=10.4049/jimmunol.174.3.1462; PMCID=PMC2245899
Chien-Chung Chang, Michael Campoli, Nicholas P. Restifo, Xin-Hui Wang, Soldano Ferrone;
Immune selection of hot-spot beta 2-microglobulin gene mutations, HLA-A2 allospecificity loss, and antigen-processing machinery component down-regulation in melanoma cells derived from recurrent metastases following immunotherapy.
J. Immunol. 174:1462-1471(2005)

PubMed=24732172; DOI=10.18632/oncotarget.1878; PMCID=PMC4039118
Francesco Sabbatino, Yang-Yang Wang, Xin-Hui Wang, Keith Thomas Flaherty, Ling Yu, David Pepin, Giosue Scognamiglio, Stefano Pepe, John Munn Kirkwood, Zachary A. Cooper, Dennie T. Frederick ...Show all 14 authors... , Jennifer A. Wargo, Soldano Ferrone, Cristina Rosa Ferrone; Show fewer authors
PDGFRalpha up-regulation mediated by sonic hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation.
Oncotarget 5:1926-1941(2014)

Cross-references
Cell line collections (Providers) CLS; 300151 - Discontinued
Cell line databases/resources cancercelllines; CVCL_3934
Anatomy/cell type resources BTO; BTO_0002941
Encyclopedic resources Wikidata; Q54814108
Polymorphism and mutation databases Cosmic; 928682
Cosmic; 1477405
Cosmic; 2757118
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number25