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Cellosaurus hFOB 1.19 (CVCL_3708)

[Text version]
Cell line name hFOB 1.19
Synonyms hFOB1.19; hFOB
Accession CVCL_3708
Resource Identification Initiative To cite this cell line use: hFOB 1.19 (RRID:CVCL_3708)
Comments Group: Patented cell line.
Group: Space-flown cell line (cellonaut).
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11372.
Doubling time: 36 hours (Note=At permissive temperature of 33.5 Celsius) (ATCC=CRL-11372).
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) [Note=tsA58].
Anecdotal: Have been flown in space on shuttle flight STS-80 to study growth in microgravity (PubMed=10719274).
Derived from site: In situ; Fetal bone, limb; UBERON=UBERON_0002428.
Cell type: Osteoblast; CL=CL_0000062.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_DG20 (hFOB/ER9)
Sex of cell Female
Age at sampling Fetus
Category Conditionally immortalized cell line
STR profile Source(s): AddexBio; ATCC; CCRID

Markers:
AmelogeninX
CSF1PO10,13
D2S133823,24
D3S135817,18
D5S81811,12
D6S104313,16
D7S8208,10
D8S117910,14
D12S39120,23
D13S31711,12
D16S5399,13
D18S5110,17
D19S43313,15
D21S1129,32.2
FGA19,22
Penta E8,11
TH017,9.3
TPOX11
vWA16,18

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Publications

PubMed=7754797; DOI=10.1002/jbmr.5650100203
Harris S.A., Enger R.J., Riggs B.L., Spelsberg T.C.
Development and characterization of a conditionally immortalized human fetal osteoblastic cell line.
J. Bone Miner. Res. 10:178-186(1995)

Patent=US5693511
Harris S.A., Spelsberg T.C.
Immortalized human fetal osteoblastic cells.
Patent number US5693511, 02-Dec-1997

PubMed=10719274; DOI=10.1016/S8756-3282(00)00234-9
Harris S.A., Zhang M., Kidder L.S., Evans G.L., Spelsberg T.C., Turner R.T.
Effects of orbital spaceflight on human osteoblastic cell physiology and gene expression.
Bone 26:325-331(2000)

PubMed=12210717; DOI=10.1002/jcb.10259
Subramaniam M., Jalal S.M., Rickard D.J., Harris S.A., Bolander M.E., Spelsberg T.C.
Further characterization of human fetal osteoblastic hFOB 1.19 and hFOB/ER alpha cells: bone formation in vivo and karyotype analysis using multicolor fluorescent in situ hybridization.
J. Cell. Biochem. 87:9-15(2002)

Cross-references
Cell line collections (Providers) ABM; T0007 - Discontinued
AddexBio; T0004005/4973
ATCC; CRL-11372
BCRC; 60357
CLS; 305069
IZSLER; BS CL 198
Cell line databases/resources CLO; CLO_0003737
CCRID; 3101HUMGNHu14
TOKU-E; 1462
Anatomy/cell type resources BTO; BTO:0004827
BTO; BTO:0005224
Biological sample resources BioSample; SAMN03471334
Encyclopedic resources Wikidata; Q54883300
Gene expression databases GEO; GSM320833
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number26