ID   hFOB 1.19
AC   CVCL_3708
SY   hFOB1.19; hFOB
DR   BTO; BTO:0004827
DR   BTO; BTO:0005224
DR   CLO; CLO_0003737
DR   ABM; T0007
DR   AddexBio; T0004005/4973
DR   ATCC; CRL-11372
DR   BCRC; 60357
DR   BioSample; SAMN03471334
DR   CCRID; 3101HUMGNHu14
DR   CLS; 305069
DR   GEO; GSM320833
DR   IZSLER; BS CL 198
DR   TOKU-E; 1462
DR   Wikidata; Q54883300
RX   Patent=US5693511;
RX   PubMed=7754797;
RX   PubMed=10719274;
RX   PubMed=12210717;
CC   Group: Patented cell line.
CC   Group: Space-flown cell line (cellonaut).
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11372.
CC   Doubling time: 36 hours (Note=At permissive temperature of 33.5 Celsius) (ATCC=CRL-11372).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) [Note=tsA58].
CC   Anecdotal: Have been flown in space on shuttle flight STS-80 to study growth in microgravity (PubMed=10719274).
CC   Discontinued: ABM; T0007; probable.
CC   Derived from site: In situ; Fetal bone, limb; UBERON=UBERON_0002428.
CC   Cell type: Osteoblast; CL=CL_0000062.
ST   Source(s): AddexBio; ATCC; CCRID
ST   Amelogenin: X
ST   CSF1PO: 10,13
ST   D12S391: 20,23
ST   D13S317: 11,12
ST   D16S539: 9,13
ST   D18S51: 10,17
ST   D19S433: 13,15
ST   D21S11: 29,32.2
ST   D2S1338: 23,24
ST   D3S1358: 17,18
ST   D5S818: 11,12
ST   D6S1043: 13,16
ST   D7S820: 8,10
ST   D8S1179: 10,14
ST   FGA: 19,22
ST   Penta E: 8,11
ST   TH01: 7,9.3
ST   TPOX: 11
ST   vWA: 16,18
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Fetus
CA   Conditionally immortalized cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 26
//
RX   Patent=US5693511;
RA   Harris S.A., Spelsberg T.C.;
RT   "Immortalized human fetal osteoblastic cells.";
RL   Patent number US5693511, 02-Dec-1997.
//
RX   PubMed=7754797; DOI=10.1002/jbmr.5650100203;
RA   Harris S.A., Enger R.J., Riggs B.L., Spelsberg T.C.;
RT   "Development and characterization of a conditionally immortalized
RT   human fetal osteoblastic cell line.";
RL   J. Bone Miner. Res. 10:178-186(1995).
//
RX   PubMed=10719274; DOI=10.1016/S8756-3282(00)00234-9;
RA   Harris S.A., Zhang M., Kidder L.S., Evans G.L., Spelsberg T.C.,
RA   Turner R.T.;
RT   "Effects of orbital spaceflight on human osteoblastic cell physiology
RT   and gene expression.";
RL   Bone 26:325-331(2000).
//
RX   PubMed=12210717; DOI=10.1002/jcb.10259;
RA   Subramaniam M., Jalal S.M., Rickard D.J., Harris S.A., Bolander M.E.,
RA   Spelsberg T.C.;
RT   "Further characterization of human fetal osteoblastic hFOB 1.19 and
RT   hFOB/ER alpha cells: bone formation in vivo and karyotype analysis
RT   using multicolor fluorescent in situ hybridization.";
RL   J. Cell. Biochem. 87:9-15(2002).
//