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Cellosaurus ES-2 (CVCL_3509)

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Cell line name ES-2
Synonyms ES2
Accession CVCL_3509
Resource Identification Initiative To cite this cell line use: ES-2 (RRID:CVCL_3509)
Comments Problematic cell line: Probably misclassified. It is dubious that this cell line originates from an African American 47 year old patient diagnosed with an ovarian clear cell adenocarcinoma. Immunohistochemical and qPCR analysis as well as its mutational profile support an ovarian serous adenocarcinoma origin (PubMed=25049276; DOI=10.26502/ogr072). Furthermore its genome ancestry clearly shows a Caucasian/European decent (PubMed=30894373) which is confirmed by mtDNA haplotyping (DOI=10.26502/ogr072).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Part of: OCCP ovarian cancer cell line panel.
Population: Caucasian.
Doubling time: 31.11 hours (JWGray panel); ~24 hours (ATCC=CRL-1978).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; PTM; Phosphorylation; Quantitative.
Omics: Proteomics; Quantitative.
Omics: Proteomics; Subcellular; Secretome.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Transcriptomics; Serial analysis of gene expression (SAGE).
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
HLA typing Source: PubMed=25960936
Class I
HLA-AA*03:01,68:02
HLA-BB*14:02,41:01
HLA-CC*07:01,08:02
Class II
HLA-DRDRB1*01:02,13:07

Source: PubMed=26589293
Class I
HLA-AA*03:01,68:02
HLA-BB*14:02,41:01
HLA-CC*07:01,08:04
Class II
HLA-DQDQA1*04:01,04:01
HLA-DRDRB1*01:02,13:05'
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.57
Native American0
East Asian, North3.68
East Asian, South0.75
South Asian7.03
European, North27.14
European, South58.83
Disease Ovarian clear cell adenocarcinoma (NCIt: C40078)
Clear cell adenocarcinoma of the ovary (ORDO: Orphanet_398971)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_JY93 (ES-2/GFP)CVCL_CZ94 (ES-2/T80)CVCL_CZ95 (ES-2/TxT50)
CVCL_M715 (ES-2R)CVCL_E8YD (ES2/GFP)CVCL_E8YE (ES2/Luciferase)
CVCL_E8YF (ES2/Luciferase-2A-GFP)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0017006/4971; ATCC=CRL-1978; Cosmic-CLP=1240128; PubMed=22710073; PubMed=25230021; PubMed=25877200; PubMed=30485824; Technion Genomics Center

Markers:
AmelogeninX
CSF1PO10,15
D1S165613,16
D2S44111
D2S133817,23
D3S135815,18
D5S81811,13
D7S82011
D8S117914
D10S124814,16
D12S39120,21
D13S31711
D16S53911,13
D18S5113,15
D19S43315,15.2
D21S1132.2 (PubMed=25230021)
32.2,33.2 (ATCC=CRL-1978; PubMed=22710073; PubMed=25877200; PubMed=30485824; Technion Genomics Center)
D22S104514,16
FGA21
Penta D8,13
Penta E13,16
TH019.3
TPOX8,12
vWA16,17

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/e/cell-lines-detail-457.html
Publications

PubMed=1717140
Derick H.M. Lau, Alexander D. Lewis, Mohamed N. Ehsan, Branimir I. Sikic;
Multifactorial mechanisms associated with broad cross-resistance of ovarian carcinoma cells selected by cyanomorpholino doxorubicin.
Cancer Res. 51:5181-5187(1991)

PubMed=9698466; DOI=10.1006/gyno.1998.5039
George Larry Maxwell, John I. Risinger, Betty Tong, Heather Shaw, J. Carl Barrett, Andrew Berchuck, P. Andrew Futreal;
Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers.
Gynecol. Oncol. 70:13-16(1998)

PubMed=11103784
Colleen D. Hough, Cheryl A. Sherman-Baust, Ellen S. Pizer, Fredrick John Montz, Dwight D. Im, Neil B. Rosenshein, Kathleen R. Cho, Gregory J. Riggins, Patrice J. Morin;
Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer.
Cancer Res. 60:6281-6287(2000)

PubMed=12960427; DOI=10.1091/mbc.E03-05-0279; PMCID=PMC266758
Marci E. Schaner, Douglas T. Ross, Giuseppe Ciaravino, Therese Sorlie, Olga G. Troyanskaya, Maximilian Diehn, Yan C. Wang, George E. Duran, Thomas L. Sikic, Sandra Caldeira, Hanne Skomedal ...Show all 26 authors... , I-Ping Tu, Tina Hernandez-Boussard, Steven W. Johnson, Peter J. O'Dwyer, Michael J. Fero, Gunnar B. Kristensen, Anne-Lise Borresen-Dale, Trevor John Hastie, Robert Tibshirani, Matt van de Rijn, Nelson N.H. Teng, Teri A. Longacre, David Botstein, Patrick O'Reilly Brown, Branimir I. Sikic; Show fewer authors
Gene expression patterns in ovarian carcinomas.
Mol. Biol. Cell 14:4376-4386(2003)

PubMed=16382445; DOI=10.1002/gcc.20300
Yan C. Wang, Dejan Juric, Brian Francisco, Ron X. Yu, George E. Duran, G. Kevin Chen, Xin Chen, Branimir I. Sikic;
Regional activation of chromosomal arm 7q with and without gene amplification in taxane-selected human ovarian cancer cell lines.
Genes Chromosomes Cancer 45:365-374(2006)

PubMed=17671176; DOI=10.1158/0008-5472.CAN-06-4567
Ryoko Kikuchi, Hitoshi Tsuda, Yae Kanai, Takahiro Kasamatsu, Kazuo Sengoku, Setsuo Hirohashi, Johji Inazawa, Issei Imoto;
Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer.
Cancer Res. 67:7095-7105(2007)

PubMed=18560578; DOI=10.1371/journal.pone.0002425; PMCID=PMC2409963
Vitor Marcel Faca, Aviva P. Ventura, Matthew P. Fitzgibbon, Sandra Rodrigues Pereira-Faca, Sharon J. Pitteri, Ann E. Green, Renee C. Ireton, Qing Zhang, Hong Wang, Kathy C. O'Briant, Charles W. Drescher ...Show all 15 authors... , Michel Schummer, Martin W. McIntosh, Beatrice S. Knudsen, Samir M. Hanash; Show fewer authors
Proteomic analysis of ovarian cancer cells reveals dynamic processes of protein secretion and shedding of extra-cellular domains.
PLoS ONE 3:e2425.1-e2425.10(2008)

PubMed=18720132; DOI=10.1080/10717540802329183
Takehiro Serikawa, Hiroshi Kikuchi, Takashi Oite, Kenichi Tanaka;
Enhancement of gene expression efficiency using cationic liposomes on ovarian cancer cells.
Drug Deliv. 15:523-529(2008)

PubMed=20081105; DOI=10.1210/me.2009-0295; PMCID=PMC2817607
Ankur K. Nagaraja, Chad Jeremy Creighton, Zhi-Feng Yu, Hui-Feng Zhu, Preethi H. Gunaratne, Jeffrey G. Reid, Emuejevoke Olokpa, Hiroaki Itamochi, Naoto Tada Ueno, Shannon M. Hawkins, Matthew Linley Anderson, Martin Matthew Matzuk;
A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer.
Mol. Endocrinol. 24:447-463(2010)

PubMed=20204287; DOI=10.3892/or_00000728; PMCID=PMC2909445
Gregory T. Langland, Steven M. Yannone, Rachel A. Langland, Aki Nakao, Ying-Hui Guan, Sydney B.T. Long, Lien Vonguyen, David J. Chen, Joe W. Gray, Fan-Qing Chen;
Radiosensitivity profiles from a panel of ovarian cancer cell lines exhibiting genetic alterations in p53 and disparate DNA-dependent protein kinase activities.
Oncol. Rep. 23:1021-1026(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22328975; DOI=10.1158/2159-8290.CD-11-0170; PMCID=PMC3274821
Aphrothiti J. Hanrahan, Nikolaus Schultz, Maggie L. Westfal, Rita A. Sakr, Dilip D. Giri, Stefano Scarperi, Manickam Janakiraman, Narciso Olvera, Ellen V. Stevens, Qing-Bai She, Carol Aghajanian ...Show all 20 authors... , Tari A. King, Elisa de Stanchina, David R. Spriggs, Adriana Heguy, Barry Stephen Taylor, Chris Sander, Neal Rosen, Douglas A. Levine, David B. Solit; Show fewer authors
Genomic complexity and AKT dependence in serous ovarian cancer.
Cancer Discov. 2:56-67(2012)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22705003; DOI=10.1016/j.humpath.2012.03.011
Munmun Rahman, Kentaro Nakayama, Mohammed Tanjimur Rahman, Naomi Nakayama, Masako Ishikawa, Atsuko Katagiri, Kouji Iida, Satoru Nakayama, Yoshiro Otsuki, Ie-Ming Shih, Kohji Miyazaki;
Clinicopathologic and biological analysis of PIK3CA mutation in ovarian clear cell carcinoma.
Hum. Pathol. 43:2197-2206(2012)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677
Christopher T. Korch, Monique A. Spillman, Twila A. Jackson, Britta M. Jacobsen, Susan K. Murphy, Bruce Arthur Lessey, Virgil Craig Jordan, Andrew Peter Bradford;
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007; PMCID=PMC4106023
Britta Stordal, Kirsten Timms, Angela Farrelly, Danielle Gallagher, Steven Busschots, Mickael Renaud, Julien Thery, Deborah Williams, Jennifer Potter, Thanh Tran, Greg Korpanty ...Show all 19 authors... , Mattia Cremona, Mark S. Carey, Jie Li, Yang Li, Ozlem Aslan, John J. O'Leary, Gordon B. Mills, Bryan T. Hennessy; Show fewer authors
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.
Mol. Oncol. 7:567-579(2013)

PubMed=23839242; DOI=10.1038/ncomms3126; PMCID=PMC3715866
Silvia Domcke, Rileen Sinha, Douglas A. Levine, Chris Sander, Nikolaus Schultz;
Evaluating cell lines as tumour models by comparison of genomic profiles.
Nat. Commun. 4:2126.1-2126.10(2013)

PubMed=24023729; DOI=10.1371/journal.pone.0072162; PMCID=PMC3762837
Michael S. Anglesio, Kimberly C. Wiegand, Nataliya Melnyk, Christine Chow, Clara M. Salamanca, Leah M. Prentice, Janine Senz, Winnie Yang, Monique A. Spillman, Dawn R. Cochrane, Karey Shumansky ...Show all 14 authors... , Sohrab P. Shah, Steve E. Kalloger, David G. Huntsman; Show fewer authors
Type-specific cell line models for type-specific ovarian cancer research.
PLoS ONE 8:e72162.1-e72162.13(2013)

PubMed=25049276; DOI=10.1136/jclinpath-2014-202430
Angie L.M. Kwok, Oscar Gee-Wan Wong, Esther S.Y. Wong, Obe Ka-Lai Tsun, Ka-Kui Chan, Annie Nga-Yin Cheung;
Caution over use of ES2 as a model of ovarian clear cell carcinoma.
J. Clin. Pathol. 67:921-922(2014)

PubMed=25230021; DOI=10.1371/journal.pone.0103988; PMCID=PMC4167545
Corine M. Beaufort, Jean C.A. Helmijr, Anna M. Piskorz, Marlous Hoogstraat, Kirsten Ruigrok-Ritstier, Nicolle Besselink, Muhammed Murtaza, Wilfred F.J. van IJcken, Anouk A.J. Heine, Marcel Smid, Marco J. Koudijs ...Show all 14 authors... , James D. Brenton, Els M.J.J. Berns, Jozien Helleman; Show fewer authors
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
PLoS ONE 9:e103988.1-e103988.16(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26388441; DOI=10.1016/j.cell.2015.08.056; PMCID=PMC4644236
Pau Creixell, Erwin M. Schoof, Craig D. Simpson, James Longden, Chad J. Miller, Hua Jane Lou, Lara Perryman, Thomas R. Cox, Nevena Zivanovic, Antonio Palmeri, Agata Wesolowska-Andersen ...Show all 18 authors... , Manuela Helmer-Citterich, Jesper Ferkinghoff-Borg, Hiroaki Itamochi, Bernd Bodenmiller, Janine T. Erler, Benjamin E. Turk, Rune Linding; Show fewer authors
Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.
Cell 163:202-217(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28273451; DOI=10.1016/j.celrep.2017.02.028
Mauricio Medrano, Laudine Communal, Kevin R. Brown, Marcin Iwanicki, Josee Normand, Joshua Paterson, Fabrice Sircoulomb, Paul M. Krzyzanowski, Marian Novak, Sasha A. Doodnauth, Fernando Jose Suarez Saiz ...Show all 19 authors... , Jane Cullis, Rima Al-awar, Benjamin G. Neel, John McPherson, Ronny I. Drapkin, Laurie Ailles, Anne-Marie Mes-Masson, Robert Rottapel; Show fewer authors
Interrogation of functional cell-surface markers identifies CD151 dependency in high-grade serous ovarian cancer.
Cell Rep. 18:2343-2358(2017)

PubMed=30485824; DOI=10.1016/j.celrep.2018.10.096; PMCID=PMC6481945
Eniko Papp, Dorothy Hallberg, Gottfried E. Konecny, Daniel C. Bruhm, Vilmos Adleff, Michael Noe, Ioannis Kagiampakis, Doreen Palsgrove, Dylan Conklin, Yasuto Kinose, James R. White ...Show all 18 authors... , Michael F. Press, Ronny I. Drapkin, Hariharan Easwaran, Stephen Bruce Baylin, Dennis Joseph Slamon, Victor E. Velculescu, Robert B. Scharpf; Show fewer authors
Integrated genomic, epigenomic, and expression analyses of ovarian cancer cell lines.
Cell Rep. 25:2617-2633(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

DOI=10.26502/ogr072
Eric J. Devor, Jace R. Lapierre, David P. Bender;
ES-2 ovarian cancer cells present a genomic profile inconsistent with their reported history.
Obstet. Gynecol. Res. 4:233-238(2021)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) AddexBio; C0017006/4971
ATCC; CRL-1978
BCRC; 60067
BCRJ; 0080
CCTCC; GDC0322
CLS; 305038
Ubigene; YC-C139
Cell line databases/resources CLO; CLO_0002947
cancercelllines; CVCL_3509
CCRID; 1101HUM-PUMC000371
CCRID; 3101HUMTCHu111
CCRID; 4201HUM-CCTCC00322
Cell_Model_Passport; SIDM00861
CGH-DB; 323-2
Cosmic-CLP; 1240128
DepMap; ACH-000906
IGRhCellID; ES2
LINCS_LDP; LCL-1806
Anatomy/cell type resources BTO; BTO_0004424
Biological sample resources BioSample; SAMN02800400
BioSample; SAMN03472439
BioSample; SAMN10988319
CRISP screens repositories BioGRID_ORCS_Cell_line; 435
Chemistry resources GDSC; 1240128
PharmacoDB; ES2_337_2019
Encyclopedic resources Wikidata; Q54832435
Experimental variables resources EFO; EFO_0002177
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM95455
GEO; GSM274699
GEO; GSM313713
GEO; GSM383926
GEO; GSM416675
GEO; GSM659376
GEO; GSM784563
GEO; GSM887008
GEO; GSM888077
GEO; GSM1001491
GEO; GSM1176276
GEO; GSM1291140
GEO; GSM1340580
GEO; GSM1341129
GEO; GSM1669769
GEO; GSM2474975
Polymorphism and mutation databases Cosmic; 844353
Cosmic; 897429
Cosmic; 1044235
Cosmic; 1102814
Cosmic; 1113277
Cosmic; 1139225
Cosmic; 1223312
Cosmic; 1305327
Cosmic; 1312191
Cosmic; 1328071
Cosmic; 1450145
Cosmic; 1708382
Cosmic; 1709256
Cosmic; 1995396
Cosmic; 2074240
IARC_TP53; 28314
LiGeA; CCLE_094
Progenetix; CVCL_3509
Proteomic databases PRIDE; PXD000901
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number48